Chapter 10 Cell death

Cell death can be divided into three main types: apoptosis, necrosis and autolysis. Chapter 9 discussed the causes of cell death.


Apoptosis, or programmed cell death, is internally regulated by the cell and is characterized morphologically by the production of membrane-bound apoptotic bodies (Fig. 3.10.1). It can occur as a normal phenomenon, as discussed in Ch. 2. In pathological circumstances, apoptosis can be involved in many different ways: for example loss of CD4 T-cells in infection by the human deficiency virus (HIV), reduction in cell number in pathological atrophy, and cell loss by apoptosis rather than necrosis at the edge of infarcts. In neoplasia, there is insufficient apoptosis: the balance between apoptosis and cell proliferation is disturbed so that cell proliferation exceeds cell loss and the net result is tumour growth.

Jul 3, 2016 | Posted by in MUSCULOSKELETAL MEDICINE | Comments Off on death
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