Chronic Lateral Epicondylitis—New Perspectives on Injection Strategies and Ultrasound Evaluation



Fig. 4.1
Ultrasonography of the common extensor tendon in a patient with lateral epicondylitis. The tendon thickness is increased, and the Doppler flow is also illustrated



To perform an ultrasonographic evaluation of the common extensor tendon, patients are examined in a sitting position with the elbow flexed to 90°, the wrist pronated, and the arm resting on a table. The transducer is aligned with the long axis of the radius over the common extensor tendon (See Fig. 4.2).

A312380_1_En_4_Fig2_HTML.jpg


Fig. 4.2
Transducer location on testing for tennis elbow. The transducer is aligned with the long axis of the radius over the common extensor tendon


Tendon Thickness

Measurement of the thickness of the common extensor tendon can be performed in different ways. In a study by Krogh et al. [23] two different techniques are described, and the intra- and inter-observer variation is excellent with both methods. Method 1, labeled “1-cm measure,” measures tendon thickness 1 cm distal from the insertion of the common extensor tendon (on top of the lateral epicondyle), perpendicular to the length of the tendon (Fig. 4.3a and c). Method 2, labeled “plateau measure,” measures tendon thickness at an anatomical landmark at the horizontal bony surface of the lateral epicondyle, which is referred to as “the plateau.” “The plateau” is a flat aspect of the capitellum of the lateral epicondyle located between the insertion of the tendon and the radio-humeral joint. Tendon thickness is measured from “the plateau” to the tendon surface perpendicular to the length of the tendon (Fig. 4.3b and c). Other authors have used similar methods for tendon thickness measurement [18, 25].

A312380_1_En_4_Fig3_HTML.gif


Fig. 4.3
Measuring the tendon thickness by ultrasound. Longitudinal sonogram illustrating two different methods (a and b) for measuring the thickness of the common extensor tendon. Labels: Lateral epicondyle (A), radiohumeral joint (B), radial head (C), common extensor tendon (D), tendon thickness 1 cm distal form the attachment (E), and tendon thickness at “the plateau” (G). Arrows indicate “the plateau” (F)


Doppler Activity

It has been shown to have a good sensitivity and specificity as a diagnostic tool for patients with LE [9, 47, 49]. The color Doppler activity is usually seen in an area limited proximally by the tip of the lateral epicondyle and distally by the humeroradial joint space. The outer border is the most superficial fibers, and the deep border is the bone (Fig. 4.1). There are several ways to assess Doppler activity, but as yet no consensus has been reached regarding which method to use. In newer studies [23, 39] color Doppler activity is graded in a new ranking scale from grade 0–4 (see Fig. 4.4). This modulation can be used both in scientific studies and in daily clinical work. The grading is estimated in a 0.5-cm longitudinal part of the tendon with the maximal Doppler activity (region of interest, ROI). The scale is as follows: Grade 0: no activity, grade 1: single vessel, grade 2: Doppler activity in less than 25 % of the region of interest, grade 3: Doppler activity in 25–50 % of the region of interest, and grade 4: Doppler activity in more than 50 % of the region of interest. Regarding color Doppler activity, the results showed an excellent correlation between the observers and an overall satisfactory agreement [23]. However, factors including probe position, probe pressure, and equipment settings including gain, wall filter, color priority, and pulse repetition frequencies can influence the outcome.

A312380_1_En_4_Fig4_HTML.gif


Fig. 4.4
Measurement of Doppler activity (grade 0–4). Longitudinal ultrasonogram of the common extensor tendon illustrating grading of color Doppler activity from grade 0–4. The horizontal yellow line, measuring 0.5 cm, marks the superficial border of the ROI, white vertical lines mark the proximal and distal borders, and the bone surface marks the deeper borders

Several other methods for assessing Doppler activity have been suggested, e.g., as a binary outcome (negative/positive), where grade 0 and 1 would count as negative Doppler activity and grade 2 or more as positive Doppler activity. In ­conclusion, it is difficult to compare the results of Doppler activity across studies because of the use of various methods.


Bony Spurs

Bony spurs (enthesophytes) were initially described on conventional radiographs [3, 40]. Bony spurring is defined as a bony outgrowth arising at the insertional site of the common extensor tendon (see Fig. 4.5). The bony spurs are easily seen on US, and several ultrasonographic studies in patients with LE have dealt with the observation of bony spurs [5, 9, 26, 39, 46]. However, the clinical significance of bony spurs is unclear.

A312380_1_En_4_Fig5_HTML.gif


Fig. 4.5
Detection of bony spurs by ultrasonography. Arrows indicating the bony spurring at the top of the lateral epicondyle (a), radiohumeral joint (b), radial head (c), and common extensor tendon (d)



Treatment


The treatment of LE varies widely from “watchful waiting” to nonsteroidal anti-inflammatory drugs, physical therapies including exercise, bracing, injection therapies, and, as a last option, surgery. Glucocorticoid injections have been used since the 1950s, and for many years have been the treatment of choice [6]. However, despite a well-documented short-term effect, several studies have shown no long-term effect [22, 27, 36, 45], and some studies have even shown that long-term benefit after corticosteroid injections is less than after other treatments. Whether this is due to an adverse effect of the corticosteroids or whether there is a marked short-term effect, after which the patients resumes the harmful overload without adequate rehabilitation, is so far unclear.

In a newer study of patients with LE by Krogh et al. [24], US of the elbow demonstrated a reduction in tendon thickness following injection of glucocorticoid and the same was observed regarding color Doppler activity. The reduction in tendon thickness observed after glucocorticoid injection goes well in hand with a study [13] that showed a reduction in tendon thickness in both patellar and Achilles tendons.

During the past 10 years, several new therapies have become available that focus on the use of growth factors (GFs), among others, as a stimulant of tendon repair. Platelet-rich plasma (PRP) is blood plasma with an increased concentration of autologous platelets. PRP is now being used as a part of wound treatment, bone healing, alloplastic surgery, and muscle/tendon damage [2, 34, 44]. PRP can potentially enhance tendon healing and tissue regeneration by delivering various growth factors and cytokines, thereby effecting cell proliferation, chemotaxis, cell differentiation, and angiogenesis. The theory is that application of PRP intratendinously will stimulate the repair mechanism and promote tendon healing [4, 7, 10].

In conclusion, we can say that the role of injection strategies in LE is doubtful, considering the long-term outcome. Ultrasound improves the diagnostic algorithm and can probably be supportive as a future outcome measure. Consensus in terms of outcome measures in clinical trials needs to be established. Despite the development of many new therapies, the most well-documented treatment is relief from the harmful activity and slow rehabilitation below the pain threshold, as recommended in The Lancet in 1882 [35].

Tags:
Jun 3, 2017 | Posted by in RHEUMATOLOGY | Comments Off on Chronic Lateral Epicondylitis—New Perspectives on Injection Strategies and Ultrasound Evaluation

Full access? Get Clinical Tree

Get Clinical Tree app for offline access