The changing demographics of total joint arthroplasty recipients in the United States and Ontario from 2001 to 2007




Background


The rates of total joint arthroplasty (TJA) of the hip and knee have increased in North America over the last decade. While initially designed for elderly patients (>70 years of age), several reports suggest that an increasing number of younger patients are undergoing joint replacements. This suggests that more people are meeting the indication for TJA earlier in their lives. Alternatively, it might indicate a broadening of the indications for TJA.


Methods


We used the administrative databases available at the Healthcare Cost and Utilization Project (HCUP) and the Institute for Clinical Evaluative Sciences (ICES) to determine the rates of TJA of the hip and knee in the United States, and Ontario, Canada, respectively. We determined the crude rates of THA and TKA in both areas for four calendar years (2001, 2003, 2005 and 2007). We also calculated the age- and sex-standardised rates of THA and TKA in both areas for each time period. We compared the age distribution of TJA recipients between the US and Ontario, and within each area over time.


Results


The crude and standardised rates of THA and TKA increased over time in both the US and Ontario. The crude rates of THA were higher in the US in 2001 and 2003, but were not significantly different from the rate in Ontario in 2005 and 2007. The crude rates of TKA were consistently higher in the US for all time periods. In addition, the US consistently had more THA and TKA recipients in ‘younger’ age categories (<60 years of age). While the age- and sex-standardised rates of TKA were greater in the US in all time periods, the relative increase in rates from 2001 to 2007 was greater in Ontario (US – 59%, Ontario – 73%). For both the US and Ontario, there was a significant shift in the demographic of THA and TKA recipients to younger patients ( p < 0.0001).


Conclusions


The utilisation of primary hip and knee arthroplasty has increased substantially in both the US and Ontario in the period from 2001 to 2007. This increase has been predominantly in knee replacements. The demographics of joint replacement recipients has become younger, with substantial increases in the prevalence of patients <60 years old amongst TJA recipients, and significant increases in the incidence of TJA in these age groups in the general population, in both the US and Ontario.


Total joint arthroplasty (TJA) is the mainstay of treatment for end-stage arthritis of the hip or knee, a stage loosely defined by unacceptable levels of pain and physical dysfunction despite adequate medical management. Both total hip arthroplasty (THA) and total knee arthroplasty (TKA) have consistently been demonstrated to provide long-lasting pain relief and substantial and sustained improvement in joint functioning and health-related quality of life . In Canada, it is estimated that by 2026 over 6 million Canadians will have arthritis, increased from 4 million in 2000 . In the United States (US), the prevalence of arthritis is projected to increase from 47.8 million in 2005 to nearly 67 million by 2030, an increase of ∼40% over 25 years . In contrast, the rates of TKA in the US and Canada increased by ∼100% and 128% in the period from 1999 to 2008 and from 1994 to 2004, respectively . The trends in the rates of TJA, particularly TKA, are greater than the projected increase in the number of people with end-stage arthritis for the same period, suggesting that the indications for TJA are broadening.


Although TJA was initially designed for older patients (generally defined as >70 years of age) , a recent report from Finland indicated that there has been a sharp increase in the number of TKAs performed for younger patients in that country . This is believed to be secondary to the ageing of the baby boomer cohort (those born in the post-war period from 1946 to 1964). However, the health-care system in Finland is publically funded, with private health care making up <5% of inpatient hospital visits. All health-care personnel including surgeons are compensated with a monthly salary, and patients can only access elective surgical care after referral from a physician . Thus, the degree to which these changes in TJA rates can be generalised to North America is unclear. Canada uses a single-payer health-care insurance system, and all Canadians require referral from a family physician for a surgical consultation. However, Canadian surgeons are paid on a fee-for-service basis, introducing a potential financial incentive to perform surgery. The US uses a combined public (in the case of Medicare and Medicaid) and private health-care insurance system. The payment to orthopaedic surgeons for each elective arthroplasty and the requirement of a physician referral to be seen by a surgeon is not standardised, as it is in Ontario. However, this potential increased access to surgery among those insured is mitigated by factors that may reduce the rates of TJA, including a higher prevalence of individuals who are non-insured or under-insured, and by documented racial disparity .


We set out to estimate and compare the crude and age- and sex-standardised rates of primary TKA and THA over the last decade in the US and Ontario, Canada. In addition, we estimated the age distribution of TJA recipients, and the changes in distribution over time for both areas. We hypothesised a rise in rates of TJA in both countries, with a greater increase in the US. We also hypothesised a shift in the demographic of recipients to younger patients, and once again expected this shift to be more pronounced in the US due to relatively increased access to surgeons.


Methods


A cross-sectional study was conducted using administrative health-care databases in Ontario, Canada (population, 12.8 million in 2010), and the US (population, 308.7 million in 2010). The utilisation of THA and TKA in Ontario, Canada and the US for four calendar years (2001, 2003, 2005 and 2007) was determined. For each case, we also extracted the patient’s age at the time of surgery (20–49, 50–59, 60–69, 70–79 and ≥80 years of age), and sex. All analyses were stratified by the joint being replaced (hip or knee).


Data sources


THAs and TKAs were defined on the basis of procedure codes from the International Classification of Diseases Ninth Edition (ICD-9; primary total hip replacement: 81.51; primary total knee replacement: 81.54), as well as the Tenth Edition (ICD-10; primary total hip replacement: 1.VA.53; primary total knee replacement: 1.VG.53).


Ontario’s hospitalisation records were obtained from the Canadian Institute for Health Information (CIHI) Discharge Abstract Database (DAD), which contains detailed records of all hospital admissions, including day-surgery and inpatient admissions. Prior to 1 April 2002, this database used ICD-9 coding; in 2002, Ontario switched to ICD-10. Population estimates for Ontario were obtained from the Registered Persons Database (RPDB), which lists demographic information (age, sex and home postal code to identify community of residence) for all Ontario residents.


Arthroplasty admissions data from the US were obtained from the Nationwide Inpatient Sample (NIS), a database released by the Healthcare Cost and Utilization Project (HCUP). The HCUP provides a synthesis of discharge-level health-care data collected by hospital associations, private data organisations as well as state and Federal government(s). In 2010, the NIS contained all discharge data from 1051 hospitals located in 45 states, which comprised over 96% of the entire US population. Population estimates for the US were obtained from the US Census.


Arthroplasty cohorts


The hospitalisation databases were used to construct eight separate cross-sectional samples (four THA and four TKA) for both the US and Ontario (for a total of 16). All adult patients (≥20 years of age) receiving elective primary THAs and TKAs in 2001, 2003, 2005 and 2007 were included. We excluded procedures performed secondary to a fracture, injury or malignant bone neoplasm, or as part of an emergency admission, as these procedures were considered unplanned. We also excluded procedures that were ‘cancelled’, ‘out-of-hospital’ or ‘abandoned after onset’.


Statistical methods


Descriptive statistics were used to examine the rates of primary TKA and THA, per 100,000 persons in 2001, 2003, 2005 and 2007 in Ontario, Canada and the US. Crude rates were determined by dividing the number of procedures performed in the population (or subgroup) by the number of persons in the population (or specific subgroup). We used NIS sampling weights to obtain estimates of the number of primary TKAs and THAs in the US. Age- and sex-standardised rates for each procedure were also generated for each time period (2001, 2003, 2005 and 2007) in both Ontario and the US. The standard population was the US population in 2001.


For each procedure, we compared the age distribution of TJA recipients at two different time points (2001 and 2007) using the chi-squared test. For each procedure, logistic regression was used to examine the influence of age on the change, between 2001 and 2007, on the odds of receiving a TJA. We used a two-tailed significance level of α = 0.01 for all tests. Analyses were performed using SAS version 9.2 (SAS Institute, Cary, NC, USA).




Results


The TJA-eligible populations (20 years of age or older) of the US and Ontario for each time period can be found in Table 1 . The populations of the US and Ontario increased by 7.1% and 10.2%, respectively, between 2001 and 2007. The rates of THA and TKA in each time period for both areas can be found in Tables 2 and 3 , respectively.



Table 1

Description of populations in United States and Ontario, Canada.


























































































































2001 2003 2005 2007 % Increase from 2001 to 2007
US Ontario US Ontario US Ontario US Ontario US Ontario
Age group
20–49 125,144,466 (61.3%) 5,417,039 (61.7%) 126,108,672 (60.4%) 5,560,842 (60.9%) 126,740,685 (59.3%) 5,649,428 (59.9%) 127,225,663 (58.2%) 5,643,113 (58.3%) 4.2% 4.2%
50–59 32,579,257 (16.0%) 1,391,085 (15.8%) 34,709,322 (16.6%) 1,495,728 (16.4%) 37,255,064 (17.4%) 1,607,622 (17.1%) 39,171,469 (17.9%) 1,703,521 (17.6%) 20.2% 22.5%
60–69 20,629,675 (10.1%) 921,544 (10.5%) 21,836,396 (10.5%) 963,814 (10.5%) 23,097,573 (10.8%) 1,016,243 (10.8%) 25,204,960 (11.5%) 1,121,069 (11.6%) 22.2% 21.7%
70–79 16,280,386 (8.0%) 708,762 (8.1%) 16,167,524 (7.7%) 726,099 (7.9%) 16,046,465 (7.5%) 733,611 (7.8%) 16,082,260 (7.4%) 747,207 (7.7%) −1.2% 5.4%
≥80 9,511,594 (4.7%) 345,097 (3.9%) 10,019,191 (4.8%) 383,278 (4.2%) 10,540,619 (4.9%) 419,119 (4.4%) 11,038,573 (5.0%) 463,221 (4.8%) 16.1% 34.2%
Sex
Female 105,646,545 (51.8%) 4,496,780 (51.2%) 107,917,791 (51.7%) 4,672,959 (51.2%) 110,151,129 (51.5%) 4,827,040 (51.2%) 112,532,199 (51.4%) 4,960,568 (51.3%) 6.5% 10.3%
Male 98,498,833 (48.2%) 4,286,747 (48.8%) 100,923,314 (48.3%) 4,456,802 (48.8%) 103,529,277 (48.5%) 4,598,983 (48.8%) 106,190,726 (48.6%) 4,717,563 (48.7%) 7.8% 10.1%
Total 204,145,378 8,783,527 208,841,105 9,129,761 213,680,406 9,426,023 218,722,925 9,678,131 7.1% 10.2%

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Nov 11, 2017 | Posted by in RHEUMATOLOGY | Comments Off on The changing demographics of total joint arthroplasty recipients in the United States and Ontario from 2001 to 2007

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