Systemic Illness and Disorders

Chapter 19


Systemic Illness and Disorders





Orthopedic injuries most commonly are associated with sports; however, infectious diseases also cause problems for athletes. Return to play issues and prevention of infection are especially important in athletes. Illness is different from injury. Illness involves the whole body; injury is more local. Both illness and injury can involve the inflammatory response. Various illnesses can target a body system. For example, a cold is an upper respiratory infection. This is different from a localized bruise on the quadriceps. Illness can be the result of infection by a pathogen—bacteria, viruses, or fungi—in which the immune system is unable to stop the progression of invasion. Illness can also be autoimmune, such as systemic lupus erythematosus (SLE), or it may be the result of an overreaction of the immune response as occurs in allergies and multiple sclerosis. Illness can be caused by a body system failure as occurs in cardiovascular disease, kidney failure, and diabetes. Systemic and local inflammatory response is an underlying factor in immune function and dysfunction. Acute inflammation is necessary for healing, but chronic inflammation is the underlying factor in many autoimmune diseases.


Disorders occur when the body’s homeostatic regulations are unable to adapt in response to internal or external influences. Examples are thermoregulating disorders and breathing pattern disorder, which is extremely common and is discussed extensively in this chapter.


Athletes, like other people, have allergies and systemic disease, and these conditions must be factored into the focused treatment plan. Cardiovascular/respiratory disease rehabilitation is a major reason for therapeutic exercise.



Immune Function



Objective




Overtraining and aggressive physical activity can suppress the immune system, predisposing to infection. Illness should be diagnosed and treated by the physician. If bacterial infection is detected, antibacterial medication may be prescribed. Digestive upset including diarrhea is common. Fever below 102° F (39° C) is usually productive during infection (often referred to as a low-grade inflammatory response) and should not be reduced unless complicating factors are present. Sanitation is always important, but even more so during illness. The main target of massage intervention is immune function support. The basic treatment plan consists of reducing the stress response, supporting parasympathetic dominance, managing pain, and promoting sleep.



Immunity in Athletes


In the resting state, the adaptive immune system appears to be largely unaffected by intensive and prolonged exercise training. However, the innate immune system, which consists of those immune cells that act as a first line of defense against infectious agents, appears to respond differentially to the chronic stress of intensive exercise. Natural killer cell activity tends to be enhanced and neutrophil function suppressed.


In general, when analyzed in resting individuals, the immune systems of athletes and nonathletes appear to be more similar than different. Of various immune function tests that show some change with athletic activity, only salivary immunoglobulin (Ig) A has emerged as a potential marker of infection risk. It is possible that each bout of prolonged exercise leads to short-term but clinically significant changes in immune function. Altered immunity may last between 3 and 72 hours. During this time, viruses and bacteria may gain a foothold, increasing the risk for both subclinical and clinical infection.


Taken together, the data suggest, but do not prove, that the immune system is suppressed and stressed for a short time after prolonged endurance exercise. If this is so, infection risk may be increased when the endurance athlete goes through repeated cycles of heavy exertion, especially if the athlete is experiencing other stressors of the immune system such as lack of sleep, mental stress, malnutrition, and weight loss.


Athletes resist reducing training workloads. Improper nutrition and psychological stress can compound the negative influence that heavy exertion has on the immune system. Indicators of overtraining include immunosuppression, loss of motivation for training and competition, depression, poor performance, and muscle soreness. Parasympathetic dominance is a very important area of therapeutic massage intervention for stress management and immune system function. In addition, several lifestyle practices may be beneficial. The athlete needs to eat a well-balanced diet, keep other life stresses to a minimum, avoid overtraining and chronic fatigue, obtain adequate sleep, and space vigorous workouts and competitive events as far apart as possible (Box 19-1).



Box 19-1   Common Infections








Herpes Simplex


Herpes infection is caused by the herpes simplex virus (HSV). After an incubation period of 3 to 10 days, symptoms are similar to those of viral influenza–like illness; the difference noted is that fluid-filled lesions usually surround the mouth and the nose. HSV is a painful, often recurring, infection seen as clusters of small, fluid-filled sacs on a base of red skin. Viruses may remain dormant in the body for years, manifesting themselves in situations of depressed immunity and stress. The outbreak is usually preceded by symptoms that can include irritability, headache, tingling, and burning or itching of the skin at the site of recurrence. Recurrent HSV labialis (fever blisters or cold sores) can shed the virus intermittently between episodes and in the absence of lesions. Treatment of primary HSV is most effective with antiviral drugs such as acyclovir or valacyclovir.



Fungal Infections


Infections involving fungi may occur on the surface of the skin, in skin folds, and in other areas kept warm and moist by clothing and shoes. Candida is a yeast—similar to a fungus. It most often affects the skin around the nails or the soft, moist areas around body openings.



Fungal infections may be treated initially with topical preparations for 2 to 4 weeks. More widespread, inflammatory, or otherwise difficult-to-treat cases may require the use of systemic antifungal drugs.




Massage Implications


When an athlete is ill, DO NOT overmassage. Regardless of the ongoing treatment plan, back off and apply general, nonspecific massage for no longer than 45 to 60 minutes with a relaxation/palliative outcome, and encourage rest, sleep, proper fluid intake, and nutritional support. If low-grade productive fever is present, the client may benefit more from sleep than from massage. The presence of a fever indicates caution for massage application. If massage is provided when low-grade fever is present, the duration and intensity of the massage should be adjusted to support comfort care only.


If massage is indicated, it would be palliative and targeted to support parasympathetic dominance, sleep, and reduction of general aching. Do not massage if fever is above 100° F (38° C), or if the client is fatigued. In general, if symptoms are manifested primarily above the shoulders, it is acceptable to massage the client. If symptoms involve the whole body, then massage could strain adaptive capacity. Ask whether the client has any sort of skin infection, and be aware of skin changes. Avoid local areas where suspected infection is present. Hand hygiene is the single most important practice in reducing the transmission of infectious agents. Cleaning and disinfection are primarily important for frequently touched surfaces. Follow all Standard Precautions from the Centers for Disease Control. Remember that athletes may be immunosuppressed. Do not expose athletes to illness. If the massage therapist is ill, he or she should avoid working until no longer contagious.



Inflammation



Objective




Within limits, inflammation is a valuable aspect of the immune response. Inflammation is the body’s normal protective response to infection and injury. Antigens are molecules, usually protein, that are on the surfaces of pathogens such as bacteria or viruses. Our bodies attack such foreign materials using white blood cells, which can produce antibodies. These antibodies help the immune system destroy antigens.


Inflammation triggered by injury operates slightly differently from an infection. When tissues are damaged, they release chemicals, such as histamine and serotonin. These chemicals attract white blood cells. This natural “defense” process brings increased blood flow to the area, resulting in an accumulation of fluid. As the body mounts this protective response, symptoms of inflammation develop. These include the following:



Inflammation can be acute or chronic. When it is acute, inflammation occurs as an immediate response to trauma or infection. The inflammatory response supports the removal of cellular debris caused by trauma and any pathogens present, but if excessive, it causes damage to surrounding tissues.


Chronic inflammation is a perpetuating factor in many chronic conditions. Chronic inflammation is a factor in disorders such as asthma, lupus, and rheumatoid arthritis, as well as in tendinopathies caused by microdamage in the collagen fibers, followed by an acute inflammation, which can evolve to chronic inflammation if healing processes are disrupted (Solomonow, 2012).


Overuse tendinopathies are a common cause of pain and disability in athletes. These conditions occur as failed healing responses to overuse tendon injury (Battery and Maffulli, 2011; Del Buono et al., 2011). Substance P (SP) is a neurotransmitter involved in the transmission of pain impulses from peripheral receptors to the central nervous system.


Substance P may be produced by primary fibroblastic tendon cells called tenocytes (Backman et al., 2011). When tendons are submitted to mechanical loading, substance P production is increased. Massage may suppress substance P levels (Field et al., 2002). If this is the case, then massage might be beneficial in the reduction of pain perception.


Having a massage after strenuous exercise appears to reduce inflammation in muscles at the cellular level. Massage may reduce the activity of inflammation-inducing proteins called cytokines in muscle cells. Massage may alter genes, thus reducing inflammation and supporting muscle adaptation to exercise (Crane et al., 2012).




Cardiovascular/Respiratory Illnesses



Objective




The most common reason for mature people to be in rehabilitation is cardiovascular/respiratory disease. Exercise is a necessary part of the rehabilitation and treatment plan for these conditions.


Cardiovascular disease is the number one cause of death in the United States; coronary artery disease (CAD) is the number one cause of death due to cardiovascular disease. CAD is caused by the collection of plaque (i.e., buildup of cholesterol, calcium, and fibrous tissue) inside a coronary vessel, resulting in a narrowing of coronary arteries (stenosis) that decreases the delivery of oxygen to the heart owing to reduced coronary blood flow.


Events leading to cardiac injury during a heart attack begin with a transient blockage of coronary blood vessels that is usually caused by a blood clot that has broken loose from an area of coronary stenosis. This reduction in blood flow to the heart is called ischemia and is typically followed by restoration of blood flow (reperfusion) when the clot dissolves. Commonly known as a heart attack, the overall process of ischemia followed by reperfusion results in cardiac injury and is technically referred to as ischemia-reperfusion (I-R) injury.


The magnitude of cardiac injury that occurs during an I-R insult is a function of the duration of ischemia—that is, a longer period of ischemia results in greater cardiac injury. For example, a relatively short duration of ischemia (e.g., 5 minutes) does not result in permanent cardiac damage but may depress cardiac function for 24 to 48 hours after the event. In contrast, a long duration of ischemia (20 minutes or longer) promotes permanent cardiac injury (muscle cell death), resulting in a myocardial infarction. The severity of a myocardial infarction is significant because cardiac muscle cells are not easily capable of regeneration; therefore, after myocardial infarction, the pumping capacity of the heart is permanently diminished.


Regular exercise lowers the risk of developing CAD and reduces the risk of cardiac injury during a heart attack. The mechanism of exercise-induced protection against cardiac injury (called cardioprotection) is unknown but may be linked to increases in “heat-shock” proteins (discussed later) and antioxidants in the heart. Animal research suggests that supplementation with nutritional antioxidants reduces I-R–induced cardiac injury and disease. Additional research is required to determine whether dietary antioxidants can provide myocardial protection in humans.


Finding ways to reduce the mortality of cardiovascular disease remains an important public health goal. In this regard, numerous studies reveal that regular exercise is cardioprotective. For example, epidemiologic studies indicate that compared with sedentary individuals, physically active people have a lower incidence of heart attack. These investigations also demonstrate that the survival rate of heart attack victims is greater in physically active individuals than in their sedentary counterparts.


Numerous epidemiologic studies indicate that regular physical activity reduces the risk of cardiovascular mortality independent of other lifestyle modifications such as diet or smoking.


The biological mechanism responsible for exercise-induced protection against cardiovascular disease continues to be investigated. In this regard, it is clear that regular exercise reduces several cardiovascular risk factors, including hypertension, diabetes mellitus, obesity, blood lipids, risk of thrombosis (blood clotting), and endothelial (blood vessel) dysfunction. Therefore, it appears that the relationship between exercise and reduced cardiovascular mortality rates is due to the reduction of one or more risk factors.


Although it is clear that regular exercise reduces the risk of developing cardiovascular disease, it is also well established that exercise training improves myocardial tolerance to I-R injury. Endurance exercise training reduces myocardial injury resulting from an I-R insult.


At present, the mechanisms behind the exercise-induced myocardial protection against I-R injury are unknown. However, at least three primary mechanisms may explain this effect: (1) improved collateral circulation; (2) induction of myocardial heat-shock proteins; and (3) improved myocardial antioxidant capacity.


Proteins play an important role in maintaining homeostasis in cardiac and other cells. Damage to existing proteins or impaired protein synthesis during I-R injury results in disturbed cellular homeostasis. To combat this type of disturbance, cells respond by synthesizing a group of proteins called heat-shock proteins. These proteins are induced by a variety of stressful conditions, including elevated body temperature and prolonged exercise.


Improved protection against free radical–mediated cardiac injury is another possible mechanism of exercise-induced cardioprotection during an I-R insult. Free radicals are highly reactive molecules with available incomplete bonds on their surface that are produced during myocardial I-R injury. Antioxidants are molecules that can remove free radicals by filling their incomplete bonds and forming a new, less reactive molecule, thereby preventing free radical–mediated cellular injury. One can make this analogy: rust is the free radical, and Rustoleum paint is the antioxidant that stops the spread of rust when applied.


Cells contain several naturally occurring enzymatic and nonenzymatic antioxidants. Primary enzymatic antioxidant defenses include superoxide dismutase, glutathione peroxidase, and catalase. Important nonenzymatic defenses are provided by compounds such as glutathione, the trace mineral selenium, and vitamins A, E, and C. Each of these antioxidants is capable of quenching radicals and preventing cellular injury.

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Jun 22, 2016 | Posted by in MANUAL THERAPIST | Comments Off on Systemic Illness and Disorders

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