Special Considerations for Cardiovascular Disease: Heart Failure


12


Special Considerations for Cardiovascular Disease: Heart Failure


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INTRODUCTION


This chapter presents background, special considerations related to exercise testing, prescription, and progression for individuals with chronic heart failure (HF). The case study that follows outlines the results for a middle-aged woman with HF who participated in a combined 24-week exercise regimen at both her cardiac rehabilitation facility (12 wk) and her fitness club (12 wk). This case study presents guidance for the design of a progressive resistance training program and aerobic conditioning with a primary goal of return to work for an individual with stable systolic HF.







Case Study 12-1



Mrs. Case Study-HF


Mrs. Case Study-HF is a 54-year-old woman weighing 67.7 kg (149 lb) with a height of 163 cm (64 in). She has a history of anteroseptal myocardial infarction (MI) treated with a percutaneous transluminal coronary angioplasty (PTCA) and stent placement. Risk factors for the subject included a family history of heart disease as both her mother and father died of MIs. She works as a United Parcel Service package handler at a large midwestern airport, and her primary goal for an exercise program is to facilitate her return to work. She is married and attributes high stress to both her job and marriage. She had been a smoker for most of her life; however, on the night of her MI, she quit cold turkey and has been smoke-free ever since. Her medications at discharge from her MI included metoprolol (a β-blocker), 25 mg; lisinopril (angiotensin-converting enzyme [ACE] inhibitor), 10 mg; baby aspirin, 81 mg; and simvastatin (anti-lipidemic), 10 mg. Her blood pressure (BP) levels have been below 120/80 mm Hg since medical management. She then performed 24 weeks of exercise: 12 weeks in cardiac rehabilitation and 12 weeks at her neighborhood fitness facility.


She was asymptomatic for 4 years and at that time began to notice episodes of chest discomfort and dyspnea during walking and cutting the grass. Chest pains were random, with pain present during an activity on one occasion but not the next. She scheduled an appointment with her cardiologist and informed him of her symptoms. He suggested she either have a treadmill test or undergo a cardiac catheterization to evaluate possible progression of disease. She opted for the cardiac catheterization procedure. Results of the catheterization procedure showed akinesis of anterolateral, anteroapical, and inferoapical walls, with anterobasal hypokinesis and an ejection fraction of 30%. Coronary artery analysis demonstrated 10% ostial left main coronary artery disease and 60%–70% in-stent restenosis of the mid-left anterior descending artery. Because of these findings, she was admitted to the hospital for a myocardial viability study that was negative. Because of the negative myocardial viability study, medical management was continued and her dosage of lisinopril was increased to 20 mg. Since then, she has not complained of any chest discomfort. Two years later, her physician again increased her lisinopril to 40 mg daily to achieve maximum benefit with ACE-inhibitor therapy. She continues to do well with medical management. Recently, a graded exercise test was performed to evaluate the patient’s appropriateness for a supervised exercise program (Table 12.1).








Table 12.1


Treadmill Graded Exercise Test Results for Mrs. Case Study-HF
























































Protocol: Naughton protocol was performed while patient was on medications.


Control blood pressure: 128/80 mm Hg


Resting heart rate: 76 bpm


3 min Stages


Speed (mph)


Grade (%) and Estimated METs


Blood Pressure (mm Hg)


Heart Rate (bpm)


I


2.0


0  


1.6


140/80


118


II


2.0


3.5


3  


150/80


134


III


2.0


7  


4  


160/80


156


IV


2.0


10.5


5  


180/80


166


Recovery Phase


Blood Pressure


Heart Rate


Immediately




2 min


140/76


126


5 min



78


During the graded exercise test, the patient stopped at the end of the second minute of stage IV due to fatigue and mild dyspnea. Muscle strength was measured by the one repetition maximum (1-RM) method according to accepted standards for leg press, horizontal squat, shoulder press, leg extension, latissimus dorsi pull-down, and biceps curl exercises.


Mrs. Case Study-HF performed the following exercise prescription/progression for 12 weeks at cardiac rehabilitation and then for an additional 12 weeks at her fitness club in her neighborhood. Her exercise training program consisted of cardiovascular training 3 days a week and resistance training 2 days a week for 24 weeks (12 wk in cardiac rehabilitation and 12 wk at her fitness club). She trained 15 minutes on both the treadmill and Schwinn Airdyne bike at 60%–80% of her heart rate reserve (HRR) following a 5-minute warm-up at 50% of HRR. Exercise intensity was increased 0.5 metabolic equivalents (METs) per week consistent with patient tolerance. During the first 12 weeks of training at cardiac rehabilitation, heart rate (HR) and rhythm were monitored continuously using a Nihon-Kohden WEP-9430 Cardiac Telemetry System. The following exercises were used for resistance training: leg press, shoulder press, leg extension, lateral pull-down, cable biceps curl, and horizontal squat starting at 50% of her 1-RM and progressing to 80%. During weeks 1 and 2, she worked at 50% and 60% of her 1-RM, respectively. During week 3, she worked at 70% of her 1-RM. For weeks 4–12, she trained at 80% of her 1-RM as outlined in Table 12.2.








Table 12.2


Progressive Resistance Training Program for Weeks 1–12 for Mrs. Case Study-HF












































Week


Monday (% RM, Sets × Repetitions)


Friday (% RM, Sets × Repetitions)


1


Baseline 1-RM testing


50, 2 × 12


2


60, 2 × 10


1-RM testing


3


70, 2 × 8


80, 2 × 8


4


80, 2 × 8


80, 2 × 8


5


80, 1 × 8


1-RM testing


6–8


60, 2 × 8


70, 2 × 8


9


80, 1 × 8


80, 2 × 8


10–11


60, 2 × 8


70, 3 × 8


12


80, 1 × 8


1-RM testing


Table 12.3 presents the exercise program recommended for Mrs. Case Study-HF that transitioned her from cardiac rehabilitation to her fitness center and was accomplished with the help of a personal trainer with experience in resistance training for individuals with HF. At week 13, dumbbell lunges, dumbbell shoulder press, and dumbbell curl were substituted for the leg extension, the machine shoulder press, and cable biceps curl, respectively. The addition of the dynamic free weight program at week 13 is beneficial for several reasons:








Table 12.3


Progressive Resistance Training Program for Weeks 13–24 for Mrs. Case Study-HF












































Week


Monday (% RM, Sets × Repetitions)


Friday (% RM, Sets × Repetitions)


13


60, 2 × 8


70, 3 × 8


14–15


80, 3 × 8


80, 3 × 8


16


80, 1 × 8


1-RM testing


17


60, 2 × 8


70, 3 × 8


18–19


80, 3 × 8


80, 3 × 8


20


80, 1 × 8


1-RM testing


21


70, 2 × 8


70, 3 × 8


22–23


70, 3 × 8


80, 3 × 8


24


80, 1 × 8


1-RM testing


  First, the neuromuscular system will likely be optimally challenged by activities that affect activities of daily living (ADL) so crucial to the quality of life for individuals with HF.


  Second, the free weight program is reproducible outside of the clinic and thus provides the subjects with resistance training techniques that can be performed independently after completion of supervised exercise.


  Lastly, the dynamic free weight program mimics the balance and strength requirements of activities such as walking and climbing stairs, facilitating the transfer of muscular strength gains to activities of daily life. This aggressive resistance training program was designed to facilitate return to work and was accomplished safely and effectively.








Description, Prevalence, and Etiology


HF is an abnormality of myocardial function in which the heart is not able to pump blood at a rate commensurate with the requirements of the metabolizing tissues or to do so only from an elevated filling pressure. There are two types of HF: systolic HF, in which the individual has a reduced ejection fraction (<35%) (HFrEf), and diastolic HF, in which the individual has a normal ejection fraction with elevated filling pressure (HFpEF). HF may also exist as a combination of the two types. HF affects about 5 million individuals in the United States, and more than 550,000 patients are diagnosed each year (17). Nearly, 1 in 100 individuals older than the age of 65 years have chronic HF, which is the most common cause of hospitalization for this age group. The total direct cost of treating patients with HF is estimated to be approximately $300 billion annually, an amount that constitutes more than what is spent on any other diagnosis (17). Etiologic factors for HF include ischemic, hypertensive, and valvular heart disease as well as a variety of metabolic, infectious, and toxic agents (11).


Exercise intolerance is a hallmark finding with chronic HF. These individuals often have a poor quality of life related to this factor as well as frequent rehospitalizations for their condition (1). As the disease progresses, patients become more incapacitated and deconditioned, unable to perform simple daily tasks without limiting dyspnea or fatigue. Muscle atrophy and loss of muscle strength and endurance are also exhibited in individuals with HF and partly explain the exercise intolerance and decreased ability to perform ADL. A comprehensive program of aerobic conditioning and resistance training has been found to improve muscle strength, muscular endurance, and cardiorespiratory fitness as well as function and quality of life (4,11,1517). Furthermore, the landmark Heart Failure: A Controlled Trial to Investigate Outcomes of Exercise Training (HF-ACTION) clinical trial (12) found that morbidity and mortality were modestly affected by aerobic training when added to usual care versus usual care alone.


Reduced cardiopulmonary factors in patients with HF were believed to be the primary contributor to the exercise intolerance demonstrated. Ejection fraction does not correlate well with exercise intolerance or dyspnea. This lack of correlation has led investigators to search for other explanations for muscle fatigue observed with HF. Results have found that peripheral factors such as blood flow, intrinsic skeletal muscle abnormalities, and neurohormonal alterations are primarily responsible for the poor exercise tolerance. The muscle hypothesis provides a connection between left ventricular dysfunction and peripheral abnormalities that include skeletal muscle myopathy and dyspnea. The peripheral abnormalities have been associated with reduced ability to perform ADL leading to a reduced quality of life in patients with HF (Fig. 12.1). The muscle hypothesis states that reduced left ventricular function results in low perfusion to the skeletal muscle. The low muscle perfusion leads to a reduced metabolic state in the skeletal muscle, causing skeletal muscle myopathy. The skeletal muscle myopathy results in an accumulation of metabolic by-products, causing muscle fatigue and activating ergoreceptors in the skeletal muscle. Ergoreceptors are afferent nerve endings that transmit signals to the central nervous system. These signals result in increased ventilation and sympathetic nervous system (SNS) stimulation, causing increased dyspnea and peripheral resistance, respectively. The long-term negative consequences of the increase in SNS activity is an increase in vasoconstriction and afterload, both of which perpetuate the HF cycle. Both aerobic exercise and resistance training positively affect the muscle, vasculature, and autonomic system, thus effectively altering this cycle (14).


Feb 15, 2020 | Posted by in SPORT MEDICINE | Comments Off on Special Considerations for Cardiovascular Disease: Heart Failure

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