Clinical manifestations
Prevalence (%)
Xerostomia
92
Xerophthalmia
95
Enlarged parotid gland
50–60
Arthralgia/arthritis
75
Raynaud’s phenomenon
40
Lung involvement
40
Interstitial nephritis
10–15
Glomerulonephritis
1–2
Lymphadenopathy
15–20
Hepatopathy
15–30
Vasculitis
5–10
Peripheral neuropathy
2–5
Myositis
1
Lymphoma
4
Table 5.2
Laboratory findings in Sjögren’s syndrome
Laboratory sign | Incidence (%) |
---|---|
Increased SE | 70–80 |
Leukopenia | 10–30 |
Thrombocytopenia | 10 |
Rheumatoid factor | 80–90 |
Hypergammaglobulinemia | 80 |
ANA | 80–90 |
Anti-Ro by ELISA method | 85–95 |
By gel precipitation | 40–60 |
Anti-La by ELISA method | 70–85 |
By gel precipitation | 25–40 |
ACLA | 15 |
AMA | 5 |
ASMA | 30 |
Anti-TPO | 25 |
Table 5.3
Revised international classification criteria for Sjögren’s syndrome
American-European Consensus |
---|
I. Ocular symptoms – a positive response to at least one of the following questions: |
Have you had daily, persistent, troublesome dry eyes for more than 3 months? Do you have a recurrent sensation of sand or gravel in the eyes? Do you use tear substitutes more than 3 times a day? |
II. Oral symptoms – a positive response to at least one of the following questions: |
Have you had a daily feeling of dry mouth for more than 3 months? Have you had recurrently or persistently swollen salivary glands as an adult? Do you frequently drink liquids to aid in swallowing dry food? |
III. Ocular signs – that is, objective evidence of ocular involvement defined as positivity for at least one of the following two tests: |
Schirmer’s I test, performed without anesthesia (<5 mm in 5 min) Rose bengal score or other ocular dye scores (>4 according to van Bijsterveld’s scoring system) |
IV. Histopathology: In minor salivary glands (obtained from normal-appearing mucosa) focal lymphocytic sialadenitis, evaluated by an expert histopathologist, with a focus score >1, defined as a number of lymphocytic foci (which are adjacent to normal-appearing mucous acini and contain more than 50 lymphocytes) per 4 mm [2] of glandular tissue
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