Genes

Full name

Role

DEFB1

Defensin beta 1

Defensins could act on many immune cells through Toll-like receptor 4, regulating the entire immune response

The involvement of b-defensin with progressive muscle degeneration in mice was identified

DENND2C

DENN domain containing 2C

Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form

ESRRB

Estrogen-related receptor b

High levels of hypoxia-inducible factor (HIF) in torn rotator cuffs are present

ESRRB has been identified as an essential cofactor of HIF in mediating the adaptation to this hypoxic environment

FGF3

Fibroblast grow factor 3

Plays a critical role in angiogenesis and mesenchymal cell mitogenesis

Mediates the cellular responses by binding to and activating a family of 4 receptor tyrosine kinases (FGF receptors FGFR1-FGFR4)