Neuromuscular and syndromic scoliosis comprises a diverse group of conditions, many of which have their own unique considerations. While treatment with bracing treatment or casting is generally the initial management in these cases, there are some diagnoses where this is either ineffective or contraindicated. For example, in patients with spinal muscular atrophy (SMA), scoliosis will develop in over 90% of patients. In these SMA patients, bracing treatment has been unable to prevent scoliosis development and can lead to respiratory complications.
15 Although a soft TLSO is sometimes used for positional support in these flaccid curves, the treatment to address the SMA scoliosis is typically surgical. In cases of slow progression and stable pulmonary function, this may be delayed until the child is old enough for spinal fusion, though many of these children experience rapid progression and undergo treatment with growing spine instrumentation. A notable consideration in the SMA population is skipping fusion levels or performing a laminectomy in the lumbar spine as the only currently available treatment for this condition requires intrathecal drug delivery which can be more difficult with a solid fusion.
In patients with cerebral palsy, scoliosis commonly develops and is more frequently observed in patients with greater functional involvement, with 30% of GMFCS V cerebral palsy patients having a moderate to severe curve by the age of 10 years.
15 There are limited data on the impact of bracing treatment on these curves in the early-onset scoliosis population, though it has been shown to be ineffective in preventing progression in the adolescent cerebral palsy population.
16 Although there are limited data on casting for patients with cerebral palsy for early-onset scoliosis, these patients have been included in other studies of neuromuscular EOS patients in general and casting is often used in attempt to postpone surgical management though this would not be expected to be curative.
14,17 In patients with continued, severe progression, growing rods have been shown to be an effective treatment though the deep infection rate is reportedly as high as 30%.
18 A frequent question in both the EOS and adolescent neuromuscular patients with progressive spinal deformity is whether the benefits of surgical management exceed the risks given the frequently severe medical comorbidities. Though each case must be evaluated individually in this respect, most series favor surgical intervention despite a high complication rate with a preference for early fusion when patient size permits.
7,19,20
Growing Spine Instrumentation
In many EOS cases, management with observation, bracing treatment or casting is sufficient to either prevent the need for instrumentation or postpone surgical intervention until an age where a definitive fusion can be performed. Nevertheless, when the scoliosis progresses aggressively despite these conservative measures or the child is not a candidate for bracing treatment or casting due to concomitant medical comorbidities,
earlier intervention may be necessary. Fusion of the very young child with a spinal deformity was once standard but has fallen out of favor as this approach resulted in small lung volumes and subsequent restrictive lung disease.
3 The last decade has witnessed the development of several “growth-friendly” alternatives. The objectives of these implants are to maximize growth of the spine and facilitate development of the thorax and lungs while controlling curve progression. Nevertheless, use of these modern implants should be delayed for as long as possible as early instrumentation is fraught with both a high complication rate and a decrease in the amount of growth or expansion over time.
21,22 These “growth-friendly” implants can be classified into three distinct subtypes including distraction-based, guided growth, and compression-based strategies.
23 Of note, due to the relatively rare nature of these curves, the majority of studies of “growth-friendly” instrumentation are comprised of series of patients with not only IIS but a diverse group of patients with early onset scoliosis.
Of the “growth-friendly” techniques, distraction-based strategies are the most commonly used including traditional growing rods, vertical expandable prosthetic titanium rib (VEPTR) device, and magnetically lengthening growing rods. Traditional growing rods consist of a proximal and distal anchor with either a screw or hook attached to the spine. These anchors are then connected by either a single rod, or preferably dual rods, with expandable segments in the middle. This segment between the anchors is intentionally not fused to allow for growth and expansion and is surgically lengthened at approximately 6 month intervals. In a series of 24 patients by Akbarnia et al. with a mean of 4-year follow-up, there was an improvement of coronal plane scoliosis curve from 82° to 36° and an average of 1.2 cm growth in T1-S1 length per year.
24 An additional series found that patients who were lengthened at ≤6 month intervals had significantly higher annual T1-S1 growth rate of 1.8 cm/yr compared with 1.0 cm/yr in patients lengthened less frequently, leading many to believe that distraction may in fact promote growth of the spine.
25 An alternative to the traditional growing rod is the vertical expandable prosthetic titanium rib (VEPTR) device developed by Robert Campbell who furthered our understanding of the chest wall deformity and resultant thoracic insufficiency syndrome that many of these children endure. VEPTRs consist of rib anchors and were initially described for the primary purpose of chest expansion. However, as the thorax and spinal development are closely linked, they have also demonstrated the ability to control the coronal curve while promoting spinal growth.
26,27
Another option is a hybrid construct, combining both the traditional concept of growing rods and VEPTR using rib anchors as the proximal attachment for a growing rod construct. This allows the theoretical advantage of avoiding any fusion of the spine at the proximal anchor site. Additionally the flexibility of the ribs as upper anchors may reduce the rigidity of the construct and help protect against rod fractures. While all of these options initially require surgical lengthenings through the growth period, a magnetically lengthening option has now obtained FDA approval. While the overall construct is similar to prior growing rods, this allows the implants to be lengthened in an office setting. The initial studies of magnetically lengthening growing rods (MCGR) appear promising with regard to achieving similar curve correction and increases in spine length with far fewer surgical procedures.
28 For example, a case-control study comparing 12 matched MCGR and traditional growing rod patients demonstrated no significant difference in spine length gains, though 57 fewer surgical procedures were performed in the MCGR group.
29 While implant complications continue to occur with MCGR, avoiding the need for routine surgical lengthening will likely have both physical and psychosocial benefits for this patient population (
Figure 3).
Although distraction-based techniques remain the most popular option for “growth-friendly” instrumentation, there are also guided growth and compression-based alternatives. Guided growth techniques aim to straighten the spine with instrumentation that allows the vertebrae to continue to grow along the path of the implants. Authors have described the Shilla technique in which there is an apical fusion and sliding screws at either end placed with minimal dissection in the hopes of avoiding spontaneous fusion.
30 The major theoretical advantage of growth guidance techniques over growing rods is that children avoid multiple surgical lengthenings though there is some evidence that less spinal growth and less correction of scoliosis is seen with Shilla compared with growing rods.
31
Another alternative approach is compression-based implants which aim to correct the scoliosis by stopping the growth of the convex side of the scoliosis without fusion and allowing growth of the concave side of the curve. This is performed via an anterior approach typically thoracoscopically in which staples, tethers, or other devices are placed across the vertebral epiphyseal plate on the convex side of the scoliosis. Although several case series on compression-based implants have demonstrated improvement in curve magnitude in scoliosis patients, due to the risk of overcorrection, these techniques are generally
reserved for patients with more limited growth potential, such as those aged 9 years or above.
32 Prospective studies are underway to study efficacy and complications. Data on thoracoscopic anterior spinal instrumentation have shown minimal effect on pulmonary function, but there are concerns regarding the pulmonary impact of one or more transthoracic surgeries if performed through an open approach. Open anterior surgery should be avoided as serial measures of lung function in older children with scoliosis treated with anterior open spine surgery have shown greater loss of pulmonary function postoperatively than with posterior spinal instrumentation.
33