Pediatric Hip Disorders



Pediatric Hip Disorders


Vidyadhar V. Upasani, MD, FAAOS, FAOA

Jessica L. Hughes, MD


Dr. Upasani or an immediate family member has received royalties from Orthofix, Inc. and OrthoPediatrics; serves as a paid consultant to or is an employee of Daedalus Medical Solutions, Inc., DePuy, a Johnson & Johnson Company, Orthofix, Inc., OrthoPediatrics, and Stryker; serves as an unpaid consultant to Indius and Pacira; has stock or stock options held in Imagen; has received research or institutional support from EOS Imaging, nView, OrthoPediatrics, and Zimmer; and serves as a board member, owner, officer, or committee member of Pediatric Orthopaedic Society of North America and Scoliosis Research Society. Neither Dr. Hughes nor any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this chapter.





Introduction

Pediatric hip disorders involve anatomic changes to the proximal femur, acetabulum, or both that affect the normal development of the hip joint. The triradiate cartilage ossification centers all appear by the age of 8 to 9 years and fuse by age 17 to 18 years. Therefore, much of the shape of the acetabulum, which plays an important role in the prognosis of hips disorders, is determined by age 8 years. Although the overall height and width of the acetabulum occurs through interstitial growth of the triradiate cartilage, the depth and shape of the acetabulum occurs through the interaction with the femoral head. The resultant deformity can lead to pain, dysfunction, and premature arthritis. Prompt recognition and intervention of the specific disorder leads to improved outcomes.


Developmental Dysplasia of the Hip

Developmental dysplasia of the hip (DDH) is described as the abnormal development of the hip joint and represents a wide spectrum of pathology, ranging from joint laxity or acetabular dysplasia on ultrasonography to hip instability and dislocation. Some form of hip instability is found in 1 in 1,000 newborns on examination, and up to 5 in 1,000 are ultimately managed.1 Risk factors include female sex, intrauterine breech presentation, swaddling as a newborn,2 positive family history, first born, oligohydramnios, and ethnicity. Commonly associated conditions include other packaging disorders such as congenital torticollis, metatarsus adductus, and congenital knee dislocations. DDH is involved in 20% to 40% of patients with osteoarthritis of the hip and up to 8% of patients undergoing total hip arthroplasty
(THA). Subluxation is a stronger predictor of early arthritis than a lower center-edge angle.

Normal development of the proximal femur and acetabulum in newborns is interdependent, requiring congruency and free motion. In DDH, this congruent relationship is lost as a result of hip instability. An abnormal relationship between the femoral head and the acetabulum leads to altered development of these structures, that is, shallow socket with anterolateral deficiency and pathologic anteversion. Repetitive instability episodes result in a cartilaginous thickened ridge on the edge of the acetabulum called the neolimbus. Intra-articular blocks to reduction include a thickened pulvinar and ligamentum teres and hypertrophic transverse acetabular ligament. Extra-articular blocks to reduction include contraction of the joint capsule in an “hourglass configuration” secondary to the iliopsoas and adductor longus tendons. Although hip dysplasia affects mostly the acetabulum, the pathologic changes to the femur can occur secondary to subluxation or dislocation and abnormal contact with the acetabulum because of excessive anteversion.



Management

Treatment outcomes are directly related to age of initial treatment and severity of the dysplasia with the best long-term results for those patients treated without surgery during infancy. Once the femoral head is concentrically reduced and the reduction is maintained, the innate growth potential in a young child will allow for development of the acetabulum. In the otherwise typically developing newborn, the Pavlik harness successfully treats approximately 90% of hips with stable dysplasia and 73% of hips with a positive Ortolani test.11 The harness dynamically places the hips in a flexed and abducted position that has been shown to aid in a concentric reduction and maintenance of that reduction to allow acetabular remodeling. The success rates of the Pavlik harness are significantly lower in the populations with neuromuscular and myelomeningocele disorders, patients with arthrogryposis, in infants with extreme ligamentous laxity (severe Ehlers-Danlos syndrome), and in infants older than 12 months. There is still debate regarding the duration and protocol of treatment with a Pavlik harness. A 2021 study that compared patients who were weaned out of the harness with those who had immediate cessation once the ultrasonography findings were normal demonstrated no difference in risk of residual hip dysplasia at 1 year despite the weaned group wearing the brace longer.12






During treatment with a Pavlik harness, patients are monitored using clinical examination and repeat ultrasonography. If the hip remains dislocated with no improvement in head position by 3 to 4 weeks, the harness is discontinued, and a closed or open reduction is often required to reduce the hip. If the hip is reducible in a Pavlik harness but remains unstable on examination, the patient can be transitioned into a rigid abduction brace for an additional 3 to 4 weeks. Some patients who are too large or strong for a Pavlik harness can be started in an abduction brace. There have been variable results regarding the residual acetabular dysplasia following use of a Pavlik harness. One study demonstrated that 29% of hips had greater than two standard deviations above the mean almost 15 months after a normal ultrasonographic assessment after treatment with the Pavlik harness.13 Potential complications of the Pavlik harness are osteonecrosis and femoral nerve palsy. A femoral nerve palsy is likely related to excessive hip flexion (>120°) and is predictive of treatment failure because treatment of a femoral nerve palsy requires discontinuation of the harness until resolution of the palsy.

Patients up to walking age with persistently dislocated hips in whom bracing was unsuccessful should undergo a closed reduction with arthrography (Figure 5) to assess whether the femoral head can be successfully reduced within the Ramsey safe zone. The Ramsey safe zone is the minimum range of hip abduction and flexion required to keep the hip reduced. Traction is one approach to aid in closed reduction to allow gentle stretching of the contracted muscles before attempted reduction. Soft-tissue lengthening can also be performed on the psoas and adductors to ease reduction and broaden the safe zone.14 Following concentric reduction, a hip spica cast is applied to be worn for 4 to 6 weeks followed by a repeat hip arthrogram to
confirm maintenance of reduction and repeat casting. Following casting, the patient usually wears an abduction brace until the acetabular dysplasia has resolved radiographically.

Long-term outcomes of closed reduction using historical treatment algorithms have demonstrated relatively high rates of residual dysplasia, need for secondary reconstructive surgery, and early arthroplasty.15 A 2021 study using contemporary algorithms showed that after 10 years, hips that underwent closed reduction, despite less severe disease, had significantly higher rates of requiring secondary surgery than open reduction (47% and 30%, respectively).16 The Iowa group reported their long-term results in patients with DDH who underwent closed reduction and noted that after a mean of 48 years, 50% of hips underwent THA, with bilateral disease in older patients posing a greater risk for surgery.17

If the hip cannot be concentrically reduced within the safe zone, an open reduction is required to remove any blocks to reduction. Open reduction can be performed through an anteromedial or anterior approach. The anteromedial approach is typically performed in infants younger than 1 year because it provides more direct access to removing the blocks to reduction. This approach is ideal for management of bilateral dislocations secondary to ease of positioning and minimal blood loss. However, caution must be taken when performing surgery near the medial femoral circumflex artery. Also, the stability of the reduction depends on the hip spica in the “human position” if a ligamentum teres reconstruction is not performed. An anterior approach can be performed in children older than 12 months with the addition of a capsulorraphy for added stability. After walking age, a femoral shortening osteotomy may be required to facilitate the reduction by decreasing tension and reducing the risk of osteonecrosis. With the femoral osteotomy, excessive femoral anteversion can be corrected as well. One study demonstrated that 54% of patients who underwent an open reduction received a THA after an average of 45 years.18

After 18 months of age, a concurrent pelvic osteotomy (Salter, Dega, or Pemberton) can be performed to aid in reduction and improve acetabular coverage. Remodeling of acetabular dysplasia occurs mostly in the first 4 years of life. There is minimal change after age 4 years; thus, patients with severe dysplasia may require a pelvic osteotomy. Regardless of the type of osteotomy, the goal is increased anterolateral coverage. The Salter innominate osteotomy is described as a rotational complete osteotomy that can obtain on average 15° of anterior and 25° of lateral coverage as it hinges off the pubic symphysis. The Dega and Pemberton procedures are incomplete osteotomies that hinge off the open triradiate cartilage. The Pemberton osteotomy disrupts both the inner and outer tables of the pelvis, stopping just before the sciatic notch and creating a posterior hinge to create more anterolateral coverage. The Dega osteotomy disrupts less of the inner table and is ideal for more lateral coverage. Overcorrection should be avoided to reduce the risk of femoroacetabular impingement (FAI).

Hip redislocations are one of the most dreaded complications related to the management of DDH. Management of a redislocation depends on the underlying cause. With early redislocation after treatment, any technical perioperative errors must be ruled out; any identified should be addressed promptly. Osteonecrosis or proximal femoral growth disturbance is another potential challenging complication following treatment. A meta-analysis demonstrated no additional risk of osteonecrosis for the following factors: open or closed treatment, delay in treatment up to 1 year of age, or surgical approach (anterior versus anteromedial).19 Historically, there has been controversy as to whether the presence of the ossific nucleus was protective or if it increased the risk of osteonecrosis during treatment of DDH. A meta-analysis demonstrated that the presence of the ossific nucleus during management of DDH in infants did not increase the risk of osteonecrosis.20 Some have suggested evaluating femoral head perfusion with a perfusion MRI to assess the risk of osteonecrosis after surgical treatment.


Adolescent or Young Adult Hip Dysplasia

Even with neonatal screening for hip dysplasia, there are cases that are not diagnosed until adolescence or adulthood. Although most of these patients may be asymptomatic, it is thought that early correction of the dysplasia would reduce the potential for degenerative hip disease. The abnormal motion results in altered contact pressures and can lead to early osteoarthritis. Thus, even mild dysplasia and slight lateralization of the hip center can increase risk for early-onset osteoarthritis. The deformity is usually multiplanar, with not only anterolateral acetabular deficiency, but also the potential for posterior and global deficiency as well as decreased acetabular depth. Coxa valga and excessive femoral anteversion are also commonly associated with hip dysplasia.

Patients may present with hip pain, particularly in the groin or along the inguinal crease (the C sign). The pain is usually insidious in onset, and lateral-based pain with a Trendelenburg gait secondary to abductor
fatigue may develop in patients. Most of these patients are otherwise healthy and active but can present with concurrent back pain and depression.21 The more severe the dysplasia is and the higher the activity levels are, the earlier these patients will present. An anterior apprehension test has a positive result if the patient has discomfort or apprehension with progressive external rotation and extension of the hip.

Imaging is an important tool in the characterization of adolescent dysplasia, so good-quality radiographs are essential for accurate diagnosis. Slight variation or rotation of the pelvis can alter the interpretation. Adolescent hip dysplasia is defined as a lateral center-edge angle (angle of Wiberg) of less than 20° or Tönnis angle greater than 10° on an AP pelvic radiograph. Other measurements obtained from the AP radiograph are the extrusion index, Shenton line, and femoral neck shaft angle. The femoroepiphyseal acetabular roof index is the angle between the acetabular index relative to the horizontal portion of the proximal femoral physeal scar (Figure 6, A). A femoroepiphyseal acetabular roof index of less than 5° represents a stable hip that does not require surgical intervention.22 On a false-profile view, anterior coverage is measured by the anterior center-edge angle (angle of Lequesne), and dysplasia is defined as an angle of less than 20°. Advanced imaging has greatly enhanced the understanding of dysplasia. Three-dimensional CT reconstruction of the pelvis facilitates accurate characterization of the morphology of the acetabulum for diagnosis and surgical planning (Figure 6, B). Magnetic resonance arthrography facilitates interpretation of labral pathology, whereas a cartilage-sensitive sequence shows cartilage damage. Positive findings of cartilage damage on MRI are predictors of poor outcomes after periacetabular osteotomy (PAO).

Management of adolescent hip dysplasia depends on the severity of the dysplasia, presence of arthritis, and the symptoms and activity level of the patient. By adolescence, the hip no longer maintains its plasticity for remodeling, and surgical intervention may often be required. Nonsurgical management for symptomatic hip dysplasia, especially hip subluxation, is less successful given the known risk of premature arthritis leading to early hip arthroplasty. However, for patients with mild acetabular dysplasia and symptoms who want to avoid surgery, anti-inflammatory agents and physical therapy focused on core and hip abductor strengthening with activity modifications may relieve symptoms in the short term. Most adolescents with hip dysplasia without the presence of arthritis undergo pelvic osteotomies to improve hip joint congruence and stability. Hip arthroscopy can be considered as an adjuvant treatment for intra-articular chondral and labral pathology. Hip arthroscopy alone is not well supported as the definitive treatment of DDH because of its inability to treat the underlying osseous acetabular deficiency and version. In addition, osteochondroplasty of a pincer lesion could increase hip instability. A 2019 study demonstrated that at 5 years after hip arthroscopy and concurrent PAO, all patients had improved patient-reported outcomes and pain scores, with no conversions to hip arthroplasty.23 With longer term follow-up, the rate of THA increases.

Many pelvic reconstructive osteotomies have been described to treat patients with DDH. Steel, Sutherland, and Dial osteotomies have all been described for closed triradiate cartilage, but each has limitations. The most commonly used osteotomy after skeletal maturity is the Ganz PAO, which uses three complete osteotomies, with preservation of the posterior column, and facilitates multidirectional correction. Femoral osteotomies to alter the varus or valgus alignment of the proximal femur may also be performed to change the stress along compromised articular cartilage. However, this is rarely used in isolation. These procedures can be used after a pelvic osteotomy to improve range of motion and joint congruence because relative femoral retroversion greatly limits hip motion and may be seen in patients with hip dysplasia. At 10- and 20-year follow-up, 86% and 60% of hips survived, respectively; the risks for PAO failure were older patient age and higher Tönnis grade.24 One study compared THA in patients with DDH, with or without prior pelvic osteotomies, at a high-volume arthroplasty center and found that patients with prior pelvic osteotomies required more bone grafting, more screw fixation, and had longer surgical times and greater blood loss.25

Although treatment of DDH remains challenging, great strides have been made in the understanding of morphology, surgical technique, and patient outcomes. Further research is warranted given advances in imaging from the specific effects of interventions on the developing pelvis.

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May 1, 2023 | Posted by in ORTHOPEDIC | Comments Off on Pediatric Hip Disorders

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