Outcome Measures in Psoriatic Arthritis

In the last decade, there have been significant advances in outcome measure research in psoriatic arthritis (PsA). In this article, the outcome measures for disease activity in individual key domains of PsA are reviewed, followed by the key patient-reported outcome measures of function, quality of life, fatigue, and a new measure for disease impact, the psoriatic arthritis impact of disease. New research into composite measures of psoriatic disease is summarized, including response measures and proposed cutoff points for disease activity. Finally, the key future issues in outcome measurement in PsA are addressed.

Key points

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Validated outcome measures are now available for the key psoriatic arthritis (PsA) domains of arthritis, skin, enthesitis, and dactylitis.
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New composite measures such as the PsA disease activity score (PASDAS) and Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Composite Exercise (GRACE) allow assessment of multiple domains in 1 score with validated response measures and absolute cutoffs for disease activity.
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Involvement of patient research partners is resulting in revision of the core set of domains for PsA and development of new outcome measures that accurately reflect patient experience.