Opioid Use and Pain Decrease Between Days 3 and 7 After Quadriceps Tendon Anterior Cruciate Ligament Reconstruction in Adolescents

Purpose

To detail pain levels and opioid consumption in the week following quadriceps tendon autograft (QT) anterior cruciate ligament (ACL) reconstruction among adolescents.

Methods

Adolescents (<19 years) undergoing ACL reconstruction with QT using an all-inside technique were enrolled at the time of surgery. All underwent general anesthesia with femoral and sciatic nerve blocks. A subset had an indwelling femoral nerve catheter until postoperative day (POD) 2. Numeric Rating Scale pain level (scale 0-10) and opioid use at defined intervals (4 PM to 12 AM the evening of surgery, 12 AM to 8 AM on POD1, 8 AM to 4 PM on POD1, POD3, and POD7) were recorded via surveys. Patients who did not return at least half of their pain surveys were excluded, and all had a minimum of POD3 follow-up. Pain levels were summarized, and pairwise comparisons between the subgroups with and without femoral nerve catheters were done. Univariate tests were performed to evaluate the association between recorded variables and outcomes of POD3 opioid use or POD3 pain ≥5.

Results

Fifty-eight patients were included. A median of 15 tablets of 5 mg of oxycodone were prescribed. On POD3, 26.8% of patients reported pain ≥5, and 26.8% reported opioid use. On POD7, 5.5% of patients reported pain ≥5, and 3.6% reported opioid use. In total, 35.2% never reported opioid use. Patients with indwelling femoral nerve catheters had lower opioid consumption during the 12 AM to 8 AM timeframe the night after surgery (0% vs 37.8%, P =.006), despite similar pain scores in this time frame (median 3/10 vs 4/10, P =.153). Only 1 opioid refill was required.

Conclusions

In adolescents, moderate pain may persist for 3 days after ACL reconstruction with QT, even with regional blocks. However, both substantial pain and opioid use are uncommon at POD7.

Level of Evidence

Level IV, retrospective therapeutic case series.

Amid the opioid epidemic, there has been an increased effort among providers to make thoughtful practice changes discouraging opioid misuse. , Avoiding the overprescription of narcotic medication after surgical procedures has been a focal point for pediatric subspecialists, as nonmedical use of leftover opioids among adolescents is a concern, and opioid misuse in this demographic is associated with future opioid abuse.

While recent work has shown that several upper extremity procedures in pediatric orthopaedics typically do not require postoperative home opioids for adequate pain control, there is only modest evidence regarding pain levels and appropriate prescribing practices after anterior cruciate ligament reconstruction (ACLR) surgery in adolescents. In a recent survey of pediatric sports medicine surgeons, 89% of respondents reported that they routinely prescribe home opioids after ACLR surgery. However, a recent series of pediatric patients who underwent ACLR with regional nerve blocks showed that >80% of patients consumed no narcotics at home after surgery when their opioid prescription was provided in a sealed envelope. The discrepancy between prescribing practices and patient needs after surgery was further highlighted in a study by Liotta et al., showing that—in a group aged 12 to 25 years who underwent ACLR with quadriceps tendon (QT) or hamstring tendon autografts—patients consumed only about one-third of prescribed opioids postoperatively.

Considering that the rate of ACLR in young patients has increased dramatically in the past 20 years, evidence-based guidance for prescribing practices in this demographic represents a potential area of improvement for opioid prescription policy. However, before making coordinated efforts to standardize and/or reduce opioid prescribing for these patients, it is important that providers have a detailed understanding of patients’ typical pain levels and opioid use in the days following surgery. It is unclear how well prior research on pain after ACLR in this population generalizes to current practice, as surgeons have gravitated toward ACLR with QT—rather than the historically preferred hamstring tendon autograft—along with perioperative nerve blocks. The purpose of this study was to detail pain levels and opioid consumption in the week following QT autograft ACLR among adolescents. It was hypothesized that >90% of pediatric patients undergoing ACLR with QT under general anesthesia with femoral and sciatic nerve blocks would report Numeric Rating Scale (NRS) pain scores <5 (0-10 scale) on postoperative day (POD) 3.

Methods

This study was performed at a tertiary care children’s hospital. After institutional review board approval, patients were enrolled prior to surgery between July 2020 and May 2024. Patients <19 years of age with traumatic rupture of the anterior cruciate ligament (ACL) who were scheduled to undergo outpatient primary ACLR with QT were eligible and were engaged by a research assistant for potential enrollment. Patients who underwent concomitant meniscal repair, partial meniscectomy, or cartilage debridement were included, with details of these treatments recorded from operative notes. Patients undergoing revision ACLR or staged or concurrent treatment for a multiligamentous knee injury were excluded. Patients who did not complete at least half of the offered postdischarge pain surveys were excluded.

All patients were treated for traumatic rupture of the ACL and resulting laxity. All operations were performed by the senior author (T.J.G.), with patients receiving general anesthesia and preoperative femoral and sciatic nerve blocks administered in the operating room by the anesthesia team after induction and prior to incision. Nerve blocks were performed under ultrasound guidance with low-intensity needle-mediated electrical nerve stimulation. Ropivacaine (0.2%) and clonidine were administered as a bolus at each block site, with a combined ropivacaine dose of 0.5 to 1.0 mg/kg. A subset of patients went home with an indwelling femoral nerve catheter and disposable elastomeric pump to administer ropivacaine at 2 mg/kg/h; this was removed and discarded by the patient or family at home on POD2. The use of an indwelling femoral nerve catheter varied on a case-by-case basis through January 2022, based on discussions between the surgeon, anesthesiologist, and the patient’s family. After January 2022, indwelling femoral nerve catheters were not used.

Surgical Technique and Perioperative Protocol

Quadriceps tendon graft harvest was performed through a 3-cm longitudinal incision above the superior pole of the patella, through which a partial-thickness all soft-tissue quadriceps tendon graft 65 to 75 mm long was harvested. If a full-thickness graft harvest was required, the deep layer of the capsulotomy was closed using an absorbable suture. The graft donor site was closed in a standard fashion using a nonabsorbable high tensile strength suture to capture the rectus tendon and close the proximal half of the site. The distal half of the site was closed with a No. 1 Vicryl (Ethicon) suture. The graft was prepared with an adjustable loop button system on both sides.

After diagnostic arthroscopy, any meniscal tear was treated with partial meniscectomy or repair based on the surgeon’s assessment. All meniscal repairs in this series were accomplished using an all-inside technique using all-suture implants (FiberStitch; Arthrex). Any chondromalacia was addressed with chondroplasty.

The ACL remnants were then debrided, and independent tibial and femoral sockets were prepared using a retrograde drilling method. The ACLR was completed using an all-inside technique, whereby the graft is passed into the joint through a cannula placed into the medial portal before being seated into the respective sockets. The suspensory fixation systems on both sides of the graft were then tightened manually with the knee in full extension and a posterior drawer force applied to the proximal tibia. Surgical incisions were closed in a standard fashion using absorbable sutures.

Postoperatively, each patient was placed in a hinged knee brace and instructed to remain touch-down weightbearing for 2 weeks. Patients were instructed to take acetaminophen and ibuprofen around the clock for 48 hours and then as needed. No formal standards for opioid prescribing were provided to practitioners, and patients were prescribed 8 to 25 tablets of 5-mg oxycodone tablets or a comparable amount of liquid oxycodone (with a weight-based dose of 0.1 mg/kg/dose) to be taken every 4 to 6 hours for pain as needed. All patients were discharged home on the day of surgery.

Data Analysis

Pain surveys were electronically sent to each patient after discharge in an automated fashion. Patients were asked to report rest pain and pain with activity using the NRS pain score over 3 periods approximating the 24-hour period after surgery (4 PM to 12 AM the night of surgery, 12 AM to 8 AM, and 8 AM to 4 PM), as well as once on POD3 and once on POD7. Surveys were delivered by Research Electronic Data Capture (REDCap) links sent to patients via e-mail or text message (see Appendix 1 , available at www.arthroscopyjournal.org ), depending on patient and family preference. Patients self-reported the opioid use over the periods outlined. Mean, median, standard deviation, and range were calculated for pain scores at the different time points. Opioid consumption was similarly analyzed. Pairwise comparisons between the subgroups with and without femoral nerve catheters were done using Wilcoxon rank-sum tests and Fisher exact tests. Univariate tests were performed to check for any association between recorded variables and the outcomes of POD3 opioid use or POD3 pain level ≥5. This threshold was chosen to represent moderate to severe pain. Statistical analysis was done in Excel (Microsoft) and Stata 14.1 (StataCorp). An α level of <.05 was used as the threshold for statistical significance.

Results

Enrollment was completed for 115 patients, 57 of whom were excluded because they did not complete at least half of the postoperative pain surveys. Compared with included patients, the group of excluded patients showed no significant difference in terms of age ( P =.58), sex ( P =.06), race ( P =.13), ethnicity ( P ≥.999), body mass index (BMI) (0.29), or Beighton score ( P =.71). After exclusions, 58 patients were included in the study ( Fig 1 ). Patient demographics and surgical details are summarized in Table 1 . There were no identified differences in the demographics, injury characteristics, or surgical variables for the patients treated with and without indwelling femoral nerve catheters ( P >.05). Only 1 patient required an opioid refill postoperatively.

Fig 1

Diagram detailing enrollment for this study.

Table 1

Baseline and Operative Variables by Subgroup

Characteristic Overall Group (n = 58) Patients With Single-Shot Femoral and Sciatic Blocks (n = 45) Patients With Single-Shot Sciatic Block and Indwelling Femoral Nerve Catheter (n = 13) P Value
Age, mean ± SD, y 15.4 ± 1.7 15.3 ± 1.7 15.4 ± 1.8 .91
Sex, n (%) ≥.999
Male 20 (34.5) 16 (35.6) 4 (30.8)
Female 38 (65.5) 29 (64.4) 9 (69.2)
Beighton score, median (range) 0 (0-8) 0 (0-8) 0 (0-6) .50
BMI, median (range) 22.4 (16.3-36.9) 23.1 (17.9-30.5) 22.4 (16.3-36.9) .81
Race, n (%) .72
Asian 3 (5.2) 3 (6.7) 0
Black 7 (12.1) 5 (11.1) 2 (15.4)
White 42 (72.4) 33 (73.3) 9 (69.2)
Other 6 (10.3) 4 (8.9) 2 (15.4)
Ethnicity, n (%) .40
Hispanic/Latino 2 (3.4) 1 (2.2) 1 (7.7)
Non-Hispanic/Non-Latino 56 (96.6) 44 (97.8) 12 (92.3)
Laterality, n (%) .75
Right 21 (36.2) 17 (37.8) 4 (30.8)
Left 37 (63.8) 28 (62.2) 9 (69.2)
Insurance, n (%) .35
Medicaid 16 (27.6) 13 (28.9) 3 (23.1)
Private 41 (70.7) 32 (71.1) 9 (69.2)
Other 1 (1.7) 0 1 (7.7)
Sports injury, n (%) 54 (93.1) 41 (91.1) 13 (100) .57
Contact injury, n (%) 45 (77.6) 35 (77.8) 10 (76.9) ≥.999
Delay to surgery, median (range), d 50.5 (16-463) 53 (16-398) 43 (19-463) .76
Pain prior to surgery, n (%) 29 (50.0) 23 (51.1) 6 (46.2) ≥.999
Preoperative antidepressant use, n (%) 3 (5.2) 3 (6.7) 0 ≥.999
Meniscal repair, n (%) .27
No repair 28 (48.3) 22 (48.9) 6 (46.2)
Medial only 6 (10.3) 6 (13.3) 0
Lateral only 18 (31.0) 14 (31.1) 4 (30.8)
Medial and lateral 6 (10.3) 3 (6.7) 3 (23.1)
Number of tablets prescribed, , median (range) 15 (8-25) 15 (8-25) 15 (15-25) .02
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Jun 27, 2026 | Posted by in PHYSICAL MEDICINE & REHABILITATION | Comments Off on Opioid Use and Pain Decrease Between Days 3 and 7 After Quadriceps Tendon Anterior Cruciate Ligament Reconstruction in Adolescents

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