Meniscal Pathology, Repair, and Transplant
Jocelyn Wittstein, MD, FAAOS
Kendall Bradley, MD
Alison Toth, MD, FAAOS
Dr. Wittstein or an immediate family member serves as a board member, owner, officer, or committee member of the American Orthopaedic Society for Sports Medicine and the Arthroscopy Association of North America. Dr. Toth or an immediate family member is a member of a speakers’ bureau or has made paid presentations on behalf of Vericel Corporation; serves as a paid consultant to or is an employee of Vericel; has received nonincome support (such as equipment or services), commercially derived honoraria, or other non-research-related funding (such as paid travel) from Arthrex, Inc., Breg, Mitek, Smith & Nephew, and Stryker; and serves as a board member, owner, officer, or committee member of the American Orthopaedic Society for Sports Medicine. Neither Dr. Bradley nor any immediate family member has received anything of value from or has stock or stock options held in a commercial company or institution related directly or indirectly to the subject of this chapter.
ABSTRACT
To provide the best treatment options for patients with meniscus tears, it is important to review the recent literature on meniscal pathoanatomy, surgical indications in the pediatric and adult population, outcomes of repair techniques for various tear patterns, and allograft transplantation. Indications for repair have expanded to include radial, root, and cleavage tears. Surgeons should also be knowledgeable about the indications for repair of and pathoanatomy of medial meniscus ramp lesions, and outcomes of meniscal allograft transplant.
Keywords: cleavage tear; meniscal allograft; meniscus tear; ramp lesion; root tear
Introduction
Management of meniscus tears has taken a divergent path, with fewer indications for arthroscopic débridement of degenerative meniscus tears, yet increased emphasis on repair of many defined tear patterns. With advances in arthroscopic techniques and implants, indications for meniscus repair have expanded far beyond peripheral longitudinal tears. Recent studies support repair of radial and horizontal cleavage tear patterns that were once indicated for débridement. The understanding of both root tear and ramp lesions and indications for surgical repair has also greatly expanded. Meniscal allograft transplant remains a viable option for the unsalvageable meniscus.
Anatomy
Meniscal anatomy has been well described, including meniscal morphology, variability in attachment sites, and vascularity originating in the periphery and penetrating the outer two-thirds. Recent anatomic studies have contributed to a deeper understanding of capsular and ligamentous attachments about the medial and lateral menisci.
A 2019 cadaver study examined the posterior attachments to the medial meniscus.1 The authors found that the meniscofemoral and meniscotibial ligaments converged at a common attachment point on the posterior horn of the medial meniscus. The meniscotibial ligament attached to the tibia approximately 6 mm distal to the posterior chondral surface of the tibial plateau and blended with the meniscocapsular attachment as it inserted on the posterior horn (Figure 1). These data may aid in understanding of pathoanatomy and repair of ramp lesions.
A 2019 study of the posterolateral meniscal anatomy defined the lateral meniscotibial ligament and popliteomeniscal fascicle attachments.2 The mobility of the lateral meniscus is evident in its anatomy, with the lateral meniscotibial attachment extending less lateral than the superior capsular attachment and only the superior and inferior popliteomeniscal fascicles attaching to the meniscus in the region of the popliteal hiatus in absence of capsular attachment (Figure 2).
Imaging
MRI is the modality of choice in the preoperative detection of meniscal tears. A 2021 meta-analysis evaluating the diagnostic accuracy of MRI in detection of medial
and lateral tears found that MRI was slightly more accurate for medial-sided tears.3 This may be due to greater presence of concomitant injury and complexity of meniscal attachments about the lateral meniscus. Sensitivity and specificity for medial tears were 92% and 90%, respectively, versus 80% and 95% in lateral tears.
and lateral tears found that MRI was slightly more accurate for medial-sided tears.3 This may be due to greater presence of concomitant injury and complexity of meniscal attachments about the lateral meniscus. Sensitivity and specificity for medial tears were 92% and 90%, respectively, versus 80% and 95% in lateral tears.
MRI is also used for preoperative planning and counseling. A 2019 study comparing decision for repair with MRI review only versus intraoperative decision making found moderate agreement on tear repairability when looking at all tear types.4 When looking specifically at vertical tears and bucket-handle tears, there was 92% and 90% accuracy for repairability. The mean distance from the meniscocapsular junction to tear site was 4.1 ± 1.3 mm in tears, given a repairable decision. When considering repair decisions for all tear types, it is likely that other factors contribute, including tear type, chronicity, and activity level.
![]() Figure 1 A and B, Photograph and illustration showing sagittal view of the posteromedial meniscus anatomy. MTL = meniscotibial ligament, PHMM = posterior horn of the medial meniscus. (Reproduced with permission from DePhillipo NN, Moatshe G, Chahla J, et al: Quantitative and qualitative assessment of the posterior medial meniscus anatomy: defining meniscal ramp lesions. Am J Sports Med 2019;47[2]:372-378, Figure 2, p. 374.) |
Nonsurgical Management
It has become increasingly apparent that surgical treatment for the degenerative meniscus tear is a second-line treatment, particularly in the setting of osteoarthritis. A study of 20-year outcomes of arthroscopic partial meniscectomy in patients aged 50 to 70 years at time of surgery noted a 15.7% conversion rate to total knee arthroplasty (TKA), with risk associated with degree of osteoarthritis at the time of surgery, older age, malalignment, and lateral meniscal resection.5 This study suggests arthroscopic partial meniscectomy should be avoided in the setting of degenerative joint disease and other risk factors for poor outcome. The European Society of Sports Traumatology, Knee Surgery, and Arthroscopy (ESSKA) 2016 Meniscus Consensus Project noted that arthroscopic partial meniscectomy for degenerative meniscus tears should be used as a second-line treatment only after 3 months of failed nonsurgical treatment with persistent pain or mechanical symptoms with positive MRI findings and minimal degenerative joint disease noted on radiographs.6
A 2021 study of rates of meniscus débridement and repair in American Board of Orthopaedic Surgery Part II examinees revealed that the number of meniscal débridements declined by 60% from 2011 to 2017, with trends toward greater numbers of meniscus repairs by sports medicine specialists and in patients younger than 30 years and age 30 to 50 years. Meniscal débridement was noted to decrease in frequency in all age groups, including those older than 50 years.7 Outcomes of débridement of degenerative meniscus tears combined with greater understanding of the progression of knee arthritis in knees with degenerative tears may have influenced declines in surgical management for degenerative meniscus tears.
Surgical Management
Surgical management of meniscus tears is largely dictated by tear pattern and presence or absence of significant osteoarthritis. Arthroscopic partial meniscectomy is indicated for unstable inner third white zone tears in the setting of lesser degrees of osteoarthritis. The ESSKA 2019 consensus statement on traumatic meniscus tears notes that repair is the primary recommendation whenever possible because of the better clinical and radiographic outcomes associated with preservation over
partial meniscectomy. The authors did not find strong evidence to support needling or application of platelet-rich plasma as augmentation for repair, but noted indications for meniscus repair have expanded to include tear types previously not repaired.8 Surgical repair of various tear types, pediatric meniscus tears, and meniscal transplantation are reviewed in the following paragraphs.
partial meniscectomy. The authors did not find strong evidence to support needling or application of platelet-rich plasma as augmentation for repair, but noted indications for meniscus repair have expanded to include tear types previously not repaired.8 Surgical repair of various tear types, pediatric meniscus tears, and meniscal transplantation are reviewed in the following paragraphs.
![]() Figure 2 Illustration of the attachments to the posterolateral meniscus including the meniscotibial ligament, posteroinferior popliteomeniscal fascicle (PIF), the posterosuperior popliteomeniscal fascicle (PSF), and the anterosuperior popliteomeniscal fascicle (ASF). ACM = tibial articular cartilage margin, aMFL = anterior meniscofemoral ligament, FCL = fibular collateral ligament, PCL = posterior cruciate ligament, pMFL = posterior meniscofemoral ligament. (Reproduced with permission from Aman ZS, DePhillipo NN, Storaci HW, et al: Quantitative and qualitative assessment of posterolateral meniscal anatomy: Defining the popliteal hiatus, popliteomeniscal fascicles, and the lateral meniscotibial ligament. Am J Sports Med 2019;47[8]:1797-1803, Figure 2, p. 1800.) |
Bucket-Handle Tears
The gold standard for repair of bucket-handle tears in the red-white or red zone of the meniscus has been inside-out repairs, but increasingly all-inside techniques have been used with mixed results. A 2021 systematic review and meta-analysis revealed an overall failure rate of 14.8% for arthroscopic repairs of bucket-handle tears, and identified only medial-sided tears and tears performed in isolation rather than with ACL reconstruction as relative risks for failure of repair.9 The overall failure rate is far less than reported in a prior systematic review of bucket-handle repairs that was limited to all-inside implants and did not include inside-out repairs, which found a 29.3% failure rate. The higher failure rate may be due to inclusion of older all-inside implant types that had a high failure rate.10 Although a significant difference was not detected for failure rate between all-inside versus inside-out repairs in the 2021 meta-analysis, a trend toward more failures in the all-inside repairs was noted. Additionally, bucket-handle tears had a significantly
higher failure rate than simple longitudinal repairs, but a similar rate when compared with simple radial or horizontal repairs.9 A 2019 review of factors predictive of failure of meniscus repair that included bucket-handle tears as well as simple repairs found concomitant ACL reconstruction to be a protective factor for meniscal healing, but it is unclear how generalizable these findings are to bucket-handle tears.11
higher failure rate than simple longitudinal repairs, but a similar rate when compared with simple radial or horizontal repairs.9 A 2019 review of factors predictive of failure of meniscus repair that included bucket-handle tears as well as simple repairs found concomitant ACL reconstruction to be a protective factor for meniscal healing, but it is unclear how generalizable these findings are to bucket-handle tears.11
Additionally, a systematic review of studies comparing inside-out with all-inside repairs included both bucket-handle and simple repairs, but excluded meniscal arrows and screws, thus including only modern all-inside implants.12 This study found no difference in outcomes between all-inside repair and inside-out repair including clinical and anatomic failure rates, functional outcome scores, and complication rates. Clinical failure was noted to be 11% versus 10% and anatomic failure to be 13% versus 16% for inside-out versus all-inside repairs, respectively. A 2021 MRI follow-up study looking at a series of all-inside bucket-handle repairs 2 years postoperatively found 90% healed and 10% had recurrent bucket-handle tears. The authors suggest that 90% healing on MRI with 10% anatomic failure is similar to results attained with inside-out repair.13 High-quality studies are particularly lacking for comparisons of all-inside and inside-out repairs of bucket-handle tears.
Root Tears
Meniscal root tears have become an increasing area of interest. Medial and lateral meniscal root tears present differently. Medial tears occur more often in older patients, with a higher body mass index, and with more evidence of baseline osteoarthritis.14 Lateral meniscal root tears are more likely to occur in the setting of concomitant ligament injury and demonstrate less extrusion on MRI.14 The meniscus root is an essential component in maintaining the hoop stresses. There is increasing evidence that meniscal root repair in patients should be the standard of care. In the absence of subchondral collapse, greater than 2 cm2 grade 3+ chondral defects, Kellgren-Lawrence grade of 3 to 4, malalignment greater than 5°, and instability, meniscal root repair has been found to be effective at avoiding progression to TKA. In a 2020 study, control patients matched by age, sex, and Kellgren-Lawrence grade reported 60% of meniscectomies progressed to TKA at an average of 74 months, compared with 26.7% of nonsurgical treatment and zero meniscal root repairs.15 This study also showed less progression of arthritis. A 2021 systematic review found that repair improves functional outcomes scores (Lysholm, Hospital for Special Surgery, International Knee Documentation Committee, and Tegner) and slows progression, but does not prevent osteoarthritis.16
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