Fig. 5.1
The distribution of young hip fractures by 10-year cohorts according to mechanism of injury, as presented by Duckworth et al. [5] (Reproduced with permission and copyright © of the British Editorial Society of Bone and Joint Surgery. From Duckworth AD, Bennet SJ, Aderinto J, Keating JF. Fixation of intracapsular fractures of the femoral neck in young patients: risk factors for failure. J Bone Joint Surg Br. 2011; 93–B:811–16 (Fig. 5))
Classification and Anatomy
The vascular anatomy of the proximal femur forms the basis for the classification of hip fractures and determines management. The major blood supply arises from the lateral and medial circumflex femoral arteries, which are branches of the profunda femoris artery [9]. At the inferior margin of the femoral neck, these vessels form an extracapsular anastomotic ring. Retinacular vessels arise from this, pierce the hip capsule, run onto the neck under the synovium and ascend in a medial direction to penetrate the head [10, 11]. The main retinacular vessel lies on the posterosuperior aspect of the neck. Additionally, there are a small contribution from the medullary canal and a negligible contribution from the ligamentum teres in adults [12].
The hip capsule inserts into the intertrochanteric line (anteriorly) and the intertrochanteric crest (posteriorly) in the region of the vascular ring [13]. Intracapsular fractures lead to injury and disruption of the retinacular vessels, leaving the blood supply to the femoral head at risk. This can result in AVN of the femoral head [14]. In contrast to this, extracapsular fractures rarely affect the blood supply to the femoral head, and hence the management is different. Classification systems commonly used include:
The Garden classification (intracapsular fractures) describes four patterns based on the degree of fracture displacement on the AP radiograph [15]:
Identification of displacement and the risk of retinacular vessel disruption (Garden 3 and 4) is the important clinical point [18, 19].
Fracture displacement on the lateral hip radiograph is not considered by the Garden classification. Angulation at the fracture site, which usually involves posterior tilt, of more than 10° is routinely considered displaced.
The Pauwels classification (intracapsular fractures) that is determined by the vertical orientation of the fracture (30°, 50°, 70°), with reference to the horizontal on an AP radiograph of the hip [20]:
Most young high-energy fractures are a type 3 pattern with a more vertical orientation [21].
Most elderly low-energy fragility fractures are type 2.
Modified Evans classification (extracapsular fractures) describes the fracture type, e.g. basicervical or reverse oblique, and can be used as a guide to the appropriate surgical management [22].
Diagnosis
In the major trauma setting, patients are assessed and managed according to routine protocols, e.g. advanced trauma life support (ATLS). There may be significant associated injuries, which must be excluded through both the primary and secondary survey. Management of the neck of femur fracture should only be carried out after other life- and limb-threatening injuries have been effectively dealt with.
Clinical Presentation
Although the majority of young patients will present few or no comorbidities, factors that might mitigate against successful stable fixation, such as chronic disease predisposing to osteoporosis (e.g. steroid use) or osteomalacia (e.g. renal failure, alcohol abuse), should be identified, especially in the presence of a low-energy injury or if the patient is older than 40 years of age [5]. In the setting of an undisplaced fracture, there may be no obvious deformity with the only finding a painful and reduced range of motion at the hip. For displaced fractures, the injured leg will classically be shortened and externally rotated. Open fractures and neurovascular injury are uncommon but should always be excluded. Associated fractures of the femoral shaft and acetabulum also need to be ruled out.
Imaging
Hip fractures are often seen on routine plain radiographs, consisting of an anteroposterior (AP) and a lateral radiograph of the hip. In approximately 2% of patients, it is not possible to determine the presence of a fracture on plain radiographs. When the diagnosis is in doubt and an occult fracture is suspected, CT or magnetic resonance imaging (MRI) may be required [23, 24]. This may have already been carried out as part of a routine CT trauma scan. Ipsilateral femoral neck fractures occur in around 5% of all femoral shaft fractures and can be easily missed [25–28], particularly if the neck fracture is undisplaced or if there are poor-quality radiographs. Meticulous assessment is essential in all cases.
Management
Initial Management
Once the primary and secondary surveys (where possible) are complete, patients with multiple injuries and those who are physiologically unstable may require ongoing resuscitation and monitoring in a critical care setting. It is essential to provide appropriate pain relief, which routinely includes systemic analgesia and regional anaesthetic blocks, e.g. fascia iliaca block, which can reduce the opiate requirements of the patient. The femoral nerve (anterior), the lateral cutaneous nerve of the thigh (lateral) and the obturator nerve (medial) lie within and on the psoas and iliacus muscles as they pass under the inguinal ligament, and the fascia iliaca covers this neurovascular bundle. As the three nerves lie in the same fascial compartment, they can be blocked by a single injection. In day-to-day practice, the femoral and lateral cutaneous nerves are regularly blocked effectively, whilst the obturator nerve is variable. An important point to consider is that the femoral branch of the genitofemoral nerve, which supplies the skin at the groin crease, lies in a different compartment and is not affected by this technique.
Historically, the application of skin traction to the affected limb was a routine practice in patients with fractured neck of the femur. The rationale was that this might provide pain relief, reduce the extent of soft tissue injury as well as aid in fracture reduction. However, traction is now not routinely recommended as these proposed benefits have not been substantiated by comparative trials in the field [29–33].
Intracapsular Fractures
Nonoperative
There are very few indications for nonoperative treatment of intracapsular hip fractures due to the significant risk of complications. Nonoperative treatment involves protected weight bearing using crutches for routinely 6 weeks. In one study comparing nonoperative treatment with surgery for undisplaced femoral neck fractures, there was a 20% rate of displacement in the group treated nonoperatively and no failures in the surgery group [34]. Additionally, fixation was associated with a reduced length of hospital stay and a shorter time to full weight bearing. Other studies have reported displacement rates as high as 46%. For these reasons, nonoperative treatment should only be considered in patients unfit for surgery (which is rare in the younger patient) or possibly in those asymptomatic patients with a delayed presentation following fracture [35, 36].
Operative
Undisplaced Intracapsular Fractures
The management choice in the vast majority of patients with undisplaced fractures, irrespective of age or other factors, is internal fixation. This is best achieved with either a cannulated screw system or a sliding hip screw device with a short plate. In a meta-analysis, there was a single nonunion (0.9%) in 118 young adults with undisplaced intracapsular femoral neck fractures managed with internal fixation [1]. The same study found the overall rate of AVN to be 5.9%, highlighting the need for patients to be kept under review for up to 2 years to detect this [37–39]. Most patients with healed fractures have a good functional outcome and can return to their pre-injury level of mobility.
Displaced Intracapsular Fractures
The majority of intracapsular neck of femur fractures are displaced, and the management principles are very different in physiologically younger and active patients when compared to their frailer elderly counterparts. For an elderly patient, the goals are to restore mobility with early weight bearing and to reduce the complications seen with prolonged bed rest. This is often best achieved with a hemiarthroplasty or total hip replacement. For a physiologically young and active patient, the aims are to preserve the femoral head, achieve union and prevent AVN. Other than in patients with a very limited life expectancy, these injuries are not amenable to nonoperative treatment. Anatomic reduction and stable robust internal fixation are essential for a good outcome [40].
The important factors to consider when deciding whether to undertake an open reduction and internal fixation of a displaced femoral neck fracture are the patient’s chronological and biological age, pre-injury level of activity, medical comorbidities and the fracture morphology. Anatomic reduction and internal fixation are the treatment of choice for most young patients with a displaced femoral neck fracture, with good results achieved in the majority of patients. Rates of nonunion are between 0% and 15.6% and AVN between 10% and 46% (Table 5.1). A meta-analysis reported the overall rates of nonunion and AVN to be 8.9% and 23%, respectively, with a rate of 6.0% and 22.5%, respectively, for displaced fractures [1]. Patients can anticipate a good functional outcome with a healed femoral neck fracture that does not progress to AVN [41–47]. The ability to achieve a good outcome by attaining an anatomic reduction and avoiding fixation failure depends on several factors that the surgeon can control [45, 48–50].
Table 5.1
The documented nonunion and AVN rates from recent large studies following reduction and internal fixation of displaced femoral neck fractures in patients younger than 60 years of age
Author | Year | Total number (displaced fractures) | Mean age (range) | Nonunion (%) | AVN (%) |
---|---|---|---|---|---|
Haidukewych et al. [41] | 2004 | 73 (51) | 36 (15–50) | 9.8 | 27 |
Damany et al. [1]a | 2005 | 500 (382) | 28 (15–50) | 6.0 | 22.5 |
Duckworth et al. [5] | 2011 | 122 (122) | 49 (17–60) | 7.4 | 11.5 |
Physiologically Older Patients
As already noted, approximately half or more of young patients with displaced femoral neck fractures are between 40 and 60 years of age. This patient group may have medical comorbidities predisposing them to hip fractures including chronic diseases associated with osteoporosis and osteomalacia [8]. Smoking is a significant risk factor for hip fractures in women under 65 years of age [51]. A large study from Edinburgh determined the risk factors for failure after internal fixation in patients under the age of 60 with displaced intracapsular neck of femur fractures [5]. In a retrospective series of 122 patients, union occurred in 83 (68%), with failure more frequent in patients aged between 40 and 60 years (37/104, 36%) than those under 40 years (2/18, 11%). The authors identified respiratory disease, alcohol excess and renal disease as independently predictive of failure on multivariate analysis. In younger patients with a history of alcohol abuse or significant other medical comorbidities, arthroplasty can be considered.
Surgical Timing
There is controversy surrounding the timing of surgery for displaced intracapsular fractures in young adults. In theory, early reduction and stabilization should allow timely re-establishment of the retinacular vessels to potentially restore blood flow to the femoral head and minimize the potential risk of AVN. However, some would argue any damage to the vessels is done at the time of injury and early intervention may not improve this.
One study compared fixation within 12 h of injury with delayed fixation (>12 h) and reported the rate of AVN to be 16% in the delayed group compared with 0% in the early fixation group [52]. However, Barnes et al. found that the timing of surgery did not affect the rates of nonunion and AVN in patients treated with reduction and fixation within the first week post-injury [14]. Experimental studies have also demonstrated that whilst cellular changes occur in the femoral head within the first 6 h postfracture, osteocyte cell death occurs more slowly and may not be apparent until 2–3 weeks following injury [53]. In the face of contradictory evidence, a sound and safe approach is to operate as soon as an appropriately skilled surgeon and equipped theatre are available. This may be on the day of injury or the following morning but probably need not be in the middle of the night. Fixation should still be considered in patients who present late (up to 1 or 2 weeks following injury), although an imperfect reduction may have to be accepted.
Surgical Protocol
To reduce the fracture, gentle traction and internal rotation are applied to the leg. Fracture reduction is assessed on both the AP and lateral images, with the convex femoral head-neck junction producing an S-shaped curve in all planes. There is a debate about what represents an adequate reduction, but a 20° varus malreduction is associated with a 55% risk of failure, and less than 10° of posterior angulation is recommended to minimize this complication also [54, 55].
There is a relationship between quality of reduction and AVN. The risk is lowest with an anatomic reduction and increases with either valgus or varus malreduction [56]. An open reduction is sometimes necessary if an acceptable reduction cannot be achieved with closed techniques. This is most conveniently done on traction. A two-incision approach is recommended:
- 1.
An anterior Smith-Peterson approach is used to expose the fracture and femoral head. Two large (2-mm) guide wires are placed in the femoral head to act as joysticks, allowing reduction of the rotational and angulatory components of the displacement (a and b on Fig. 5.2).
- 2.
A lateral incision is used to fix the reduced fracture using either cannulated screws or a sliding hip screw with a short plate (c and d on Fig. 5.2).
Fig. 5.2
Surgery for displaced intracapsular fractures in the young. See text for details (Reproduced with permission from McRae’s Orthopaedic Trauma 3rd Edition by White et al.)
Post-surgery, patients can be mobilized touch weight bearing for a total of 6 weeks. Union of a femoral neck facture is slow and routinely takes longer than 6 months in most cases [14]. AVN is a late complication, usually presenting postfracture union, and is most common in the second year after injury [14]. It is recommended that patients should be kept under clinical review with regular radiographs for 2 years to detect this complication.
Role of Capsulotomy
There is a rise in intracapsular pressure due to the haemarthrosis that arises from an intracapsular fracture, and this can cause a tamponade effect which might impede blood flow to the femoral head [57–59]. For this reason, aspiration or capsulotomy to decompress the haemarthrosis seems a sensible option [40]. Despite this, the efficacy of these techniques has not been clearly demonstrated in clinical studies, and whilst there remain advocates, aspiration or capsulotomy is now rarely recommended [14, 60, 61].
Implant Selection and Positioning
There is no definitive consensus on the optimal device for fixation of displaced intracapsular fractures in young patients, with either cannulated screws or a sliding hip screw commonly used. Both these techniques allow controlled linear compression at the fracture to promote union. More rigid methods of fixation, such as blade plates and locked plate systems, have an increased risk of cut-out with repetitive loading [62]. The disadvantage of implants that allow compression is that shortening of the femoral neck can occur and this may have an effect on abductor biomechanics, joint reaction force and ultimately gait. Stockton et al. reported on 65 patients under the age of 60 years old who underwent internal fixation, with 32% having leg shortening of more than 1 cm [63]. Femoral neck shortening and loss of offset may be associated with poorer functional outcomes in younger patients [64, 65].
Three cannulated screws are more stable than two, but there is no additional advantage known in using four [66, 67]. There is controversy regarding the optimal position of screws, particularly whether they should be divergent or parallel, but there is no strong evidence to prove that position greatly influences outcome. However, we advocate the use of three partially threaded cannulated screws in the configuration found in Fig. 5.3. It has been suggested that a fully threaded posterior screw could improve stability in a commonly comminuted and length-unstable region of the fracture. This would prevent posterior angulation and give controlled compression in the anteroinferior region. Schaefer et al. performed a biomechanical study using a saw bone femora and reported this proposed construct to have higher bending stiffness and less failure compared to three partially threaded screws, although there are no clinical studies analysing this [68]. Vertically orientated Pauwels’ type III fractures have a tendency to fail through shear, and there is some evidence that they should be fixed with a sliding hip screw and a short plate rather than with cannulated screws [21].
Fig. 5.3
The author’s preferred configuration for cannulated screw fixation (Reproduced with permission from McRae’s Orthopaedic Trauma 3rd Edition by White et al.)
Ipsilateral Femoral Neck and Shaft Fractures
An associated femoral neck fracture occurs in approximately 5% of femoral diaphyseal fractures, and the injury may be missed. Risk factors for missing an associated injury are if the hip fracture is undisplaced or if the radiographs of the proximal femur are inadequate or are of poor quality [25–28]. There are three common clinical scenarios in which an ipsilateral femoral neck and shaft fracture occur.
The first is if when the femoral neck fracture is diagnosed preoperatively and is undisplaced. Although a cephalomedullary nail could be used to fix both factures with one implant, there is a risk of hip fracture displacement during nailing, and it is therefore essential to place heavy guide wires across the fracture to minimize this risk. This risk can be prevented altogether by first addressing the hip fracture with the most suitable implant, e.g. a sliding hip screw and plate, and then treating the femoral shaft fracture with a secondary implant, e.g. a retrograde intramedullary nail (Fig. 5.4). Otherwise, if plate fixation of the shaft is preferred, a sliding hip screw with a long plate may be used.