Controversy: Comparison of the Literature on PNF and CCH as Minimally Invasive Treatment Options for Dupuytren Disease

 

Author

Lermusiaux et al. (2001)

Foucher et al. (2003)

Van Rijssen et al. (2006)

Pess et al. (2012)

Hurst et al. (2009)

PNF

PNF

PNF

PNF

CCH

SAE

 Tendon injury

0.01%
   
0.6%

 Pulley injury
     
 CRPS
 
0.5 %
  
0.3 %

 Nerve injury
 
0.5 %
 
0.1 %
 
AE

 Skin fissures

2 %

10 %

48 %

3 %
 
 Temporary dysaesthesia

0.8 %

3 %

7 %

1 %
 
 Pain

0.3 %

6 %
   
 Injection site pain
    
32 %

 Upper extremity pain
    
31 %

 Infection

0.2 %
    
 Haematoma

0.2 %
    
 Oedema
 
0.5 %
  
72 %

 Bleeding
 
0.5 %
   
 Contusion
    
51 %

 Injection site haemorrhage
    
37 %

 Injection site swelling
    
21 %

 Tenderness
    
27 %

 Ecchymosis
    
25 %

 Pruritus
    
16 %

 Skin laceration
    
11 %

 Lymph node affection
    
21 %

 Erythema
    
6 %

 Blister
    
5 %

 Others
    
24 %


SAE treatment-related serious adverse event, AE treatment-related adverse event; others included all complications each occurring in less than 5 % of cases: axillary pain, arthralgia, vesicles at injection site, inflammation, blood blisters, joint swelling, headache and swelling





20.2.5 Aftercare and Discomfort


Following PNF, the treated area is covered with a small bandage that can be removed by the patient within a day, after which almost all activities can be resumed. If a skin fissure has occurred, a Band-Aid may be needed a bit longer. Splints are not used routinely by everybody. Pain after PNF is rare.

Hands treated with CCH in the initial studies have been immobilized in a bulky dressing until cord release. Thereafter a removable splint was fitted. With increased experience these measures have not been found necessary to obtain a good result. Hands are usually swollen and painful for a number of days and patients return to normal activities after 4 days (Warwick et al. 2015). Axillary lymphadenopathy can occur and be painful for a few days too.


20.2.6 Time Off Work


After PNF as well as after CCH treatment, the general advice to patients is to refrain from heavy labour until 2 weeks after treatment (Pess et al. 2012). Exact figures about time to return to work are not available.



20.3 Outcome of Both Procedures



20.3.1 Early Outcome (Table 20.2)





Table 20.2
Comparison of early outcome





















 
Pess et al. (2012)

Van Rijssen et al. (2012b)

Nydick et al. (2013)

Witthaut et al. (2013)

Badalamente et al. (2015)

PNF

PNF

PNF

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Oct 4, 2017 | Posted by in ORTHOPEDIC | Comments Off on Controversy: Comparison of the Literature on PNF and CCH as Minimally Invasive Treatment Options for Dupuytren Disease

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