Microorganism
Antibiotic
Three times daily
Two times daily
Once time daily
MS S. aureus
MS coagulase-negative Staphylococcus
Streptococcus spp.
Propionibacterium acnes
Amoxicillin/clavulanic acid 500–800/125 mg
X
Clindamycin 300 mg
X
TMP-SMX 800/160 mg
X
Doxycycline 100 mg
X
Levofloxacin 500 mg
X
MR S. aureus
MR coagulase-negative
Staphylococcus
Corynebacterium spp.
Clindamycin 300 mg
X
TMP-SMX 800/160 mg
X
Doxycycline 100 mg
X
Enterobacteriaceae
Amoxicillin/clavulanic acid 500–800/125 mg
TMP-SMX 800/160 mg
Doxycycline 100 mg
Ciprofloxacin 500 mg
X
Pseudomonas spp.
Ciprofloxacin 500 mg
X
Anaerobics
Clindamycin 300 mg
X
Metronidazol 500 mg
X
Table 15.1 shows some practical examples of adequate chronic antibiotic suppression for some specific microorganisms. Of course, the possibilities of potential infectious agents and treatments are very much wider.
Another controversial aspect of antibiotic suppression is the length of treatment. Some authors did not include patients treated with less than 6 months of antibiotic suppression [1, 4–6]. Therefore, we must ensure that antibiotic suppression for patients that are not able to undergo surgery will last as long as the life of patients [1–7].
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