Traumatic Lumbar Injuries, MIS Options
Alexandra Miller
Daniel Cavanaugh
Tristan B. Weir
Kelley E. Banagan
Steven C. Ludwig
REBUTTAL ▪ The Case against MIS Lumbar Fractures Fixation
Abdulrazzaq Alobaid
TRAUMATIC LUMBAR INJURIES, MIS OPTIONS
Minimally invasive spine surgery (MISS) techniques have advanced in the recent decade, primarily championed for degenerative lumbar disorders, and are now a valuable treatment modality for deformity, tumor, infection, and trauma. Minimally invasive techniques represent a valuable option for trauma patients who may have concurrent life-threatening injuries. These techniques allow for rapid stabilization of the injury, which permits early patient mobilization, one of the key principles in the care of a critically injured patient.
The advent of new surgical technology such as modern fluoroscopy and cannulated pedicle screw systems has facilitated the application of minimally invasive surgery to the field of spinal trauma. The incidence of spinal injury in the United States has been reported to be as high as 6.3% in patients with blunt trauma. This equates to nearly 150,000 patients with vertebral column injury per year in North America alone. The most common mechanism of injury is motor vehicle collisions, followed by falls from height, and domestic violence. The most commonly injured area of the thoracic and lumbar spine is the thoracolumbar junction; over 50% of thoracolumbar fractures occur at T12-L3.1 These injuries can impart significant long-term sequela and pose a large financial impact on both individual patients and society. The National Spinal Cord Injury Statistical Center estimates the lifetime direct costs for persons injured at age 25 range from 2.1 to 5.4 million dollars, varying by severity of injury. Much of this cost is attributable to improved life expectancy in the spinal cord injury population secondary to advances in care, higher-than-average hospital readmission rates in the recovery phase, and the costs of postaccident rehabilitation after spinal cord injury.2,3
In the past, techniques such as traction, casting, and bedrest were commonplace for fracture treatment, even as late as the 1990s. Without definitive stabilization, however, the complication rate of these nonoperative measures was high. With the advancement of minimally invasive technology, early stabilization of the spine has become the standard of care as this allows for early patient mobilization and facilitates appropriate nursing care. A large metaanalysis in 1992 by the Scoliosis Research Society demonstrated that surgical intervention leads to greater improvement in neurologic function when compared to nonoperative treatment, particularly in patients with deteriorating neurologic function. The same group also demonstrated that patients who underwent surgical stabilization had less residual deformity and improved pain.4
The concept of “damage control orthopedics,” coined by Scalea et al. in 2000 was first used to describe emergent external fixation of long bone fractures. External fixation provides stabilization and reduction while offering the advantage of a less morbid procedure—shorter surgical time, decreased blood loss, and early mobilization and rehabilitation. Early intervention with external fixation provides a bridge to definitive therapy, and minimizes the sustained physiologic burden from a more morbid procedure after the patient has already been subjected to a significant
physiologic blow from the trauma itself.5 Early fixation in spine trauma serves to stabilize the injury site and minimize further neurologic impairment, while minimizing the secondary physiologic burden seen with open procedures. Again, early mobilization remains key in the treatment of a poly-trauma patient.6 McHenry et al.7 demonstrated that early stabilization (less than 48 hours) of thoracolumbar fractures is associated with a decreased risk of respiratory failure in polytrauma patients. Respiratory failure developed in 140 of the 1,032 patients at a level I trauma center; time until operative stabilization was the only risk factor identified that could be controlled by the physician. MISS is reported to offer shorter surgical time, negligible blood loss, early mobilization, and prompt rehabilitation.8, 9, 10, 11 Percutaneous MISS provides early benefits, while minimizing an increase in the physiologic burden to the already vulnerable trauma patient.
physiologic blow from the trauma itself.5 Early fixation in spine trauma serves to stabilize the injury site and minimize further neurologic impairment, while minimizing the secondary physiologic burden seen with open procedures. Again, early mobilization remains key in the treatment of a poly-trauma patient.6 McHenry et al.7 demonstrated that early stabilization (less than 48 hours) of thoracolumbar fractures is associated with a decreased risk of respiratory failure in polytrauma patients. Respiratory failure developed in 140 of the 1,032 patients at a level I trauma center; time until operative stabilization was the only risk factor identified that could be controlled by the physician. MISS is reported to offer shorter surgical time, negligible blood loss, early mobilization, and prompt rehabilitation.8, 9, 10, 11 Percutaneous MISS provides early benefits, while minimizing an increase in the physiologic burden to the already vulnerable trauma patient.
SPINE TRAUMA MANAGEMENT
Classification, Indications, and Goals of MISS
The concept of stability of spine injuries and fractures remains rather enigmatic. When assessing an injury to the spinal column, one must consider that the definition of stability is the ability of the spine to withstand a physiologic load without significant displacement or deformity. In an effort to clarify this subject, many investigators have developed classification schemes that aim to infer stability based on the radiographic appearance of the injury. The Denis three vertebral column system, for example, correlates middle and posterior column injuries with instability.12, 13, 14 The AO/Modified Magerl classification was also proposed, but like the Denis system, it ignored one of the most important factors in surgical decision making: neurologic status.
For this reason, the Spine Trauma Study Group Multiple developed the Thoracolumbar Injury Classification and Severity Score (TLICS) in 2005. While still considering the importance of fracture morphology and mechanism, TLICS added a weighted category for both the neurologic status and integrity of the posterior ligamentous complex (PLC). The goal of this schema was to clarify the indications for surgery through the calculation of a numerical score (for more information about TLICS scoring, see Chapter 21—Posterior Thoracic Options: Minimally Invasive Options for Traumatic Conditions). Surgical decision making with TLCIS depends on three factors: (1) morphology of injury associated with immediate stability; (2) integrity of the PLC associated with long-term stability; and (3) neurologic status of the patient associated with morbidity. The authors believe the following injury patterns could benefit from the use of MISS for the stabilization of thoracolumbar spine trauma: unstable thoracolumbar burst fractures, stable burst fractures that cannot be treated with an orthosis due to patient-related factors and comorbidities, unstable flexion-distraction injuries, unstable extension-distraction injuries, fracture-dislocations, and unstable sacral fractures requiring lumbopelvic fixation.8, 9, 10, 11,15
Regardless of the approach chosen to manage traumatic thoracolumbar spine injuries, the treatment goals remain the same: prevention of neurologic deterioration, enhancement of neurologic recovery, stabilization of the spine to facilitate rehabilitation, restoration of proper spinal alignment, and prevention of late pain and posttraumatic spinal deformity. Advances in MISS techniques have allowed surgeons to deliver these surgical goals while avoiding the morbidity associated with traditional open management via the posterior approach to the spine. Such advances include improved percutaneous fixation methods, powerful reduction and rod passage maneuvers, and evolving fusion techniques. Reliable radiographic guidance for the placement of pedicle screws has also created a safe means for surgeon education and familiarity with MISS.8, 9, 10, 11,15
Benefits of MISS versus Open Procedures
For many thoracolumbar injuries, open surgical exposure is accomplished via a posterior approach. The greatest morbidities of this approach are increased blood loss and risk of infection, greater muscle and soft tissue compromise, and prolonged recovery. MISS seeks to overcome the major disadvantages of the open approach by minimizing soft tissue trauma. The advantages of MISS are especially valuable in the physiologically burdened trauma population.
Literature has shown that minimally invasive cases have decreased blood loss and shortened length of stay at the hospital. Traditional open techniques have been reported to have a median estimated blood loss (EBL) of more than 1,000 mL per case.15 Al-Khouja et al. performed a large literature review of 12,425 cases (3,675 undergoing MISS and 8,750 undergoing open procedures) and reported lower EBL with MISS (10 to 392.5 mL) versus the open approach (55 to 535.5 mL). The reduced length of stay for MISS (0.93 to 5.1 days vs. 1.53 to 12 days in open procedures) also translated into decreased costs compared to the open approach.16
Open procedures in spine trauma patients have a reported postoperative infection rate of up to 10%,17 which is much higher than the reported infection rates of MISS. O’Toole et al.18 reported three (0.22%) postoperative surgical site infections (SSI) among 1,338 MISS procedures in 1,274 patients (2 superficial and 1 deep SSI), which is similar to MISS infection rates reported by other authors.19,20 McAfee et al.20 reported a SSI rate of 0% to 0.22% in MISS procedures compared to 1.5% to 10% when using the traditional open approach performed by the same surgeons in a large analysis of 95,161 matched paired cases. The consistency of the lower infection rates in MISS across multiple studies suggests that MISS is superior to the traditional open approach in terms of lower infection rates.
The traditional open posterior approach results in significant muscle and soft tissue morbidity during the dissection. This occurs from muscle denervation and ischemia, leading to paraspinal atrophy and decreased postoperative paraspinal strength. In a cadaveric study comparing the risk of medial branch nerve transection in percutaneous versus mini-open placement of pedicle screws, the percutaneous technique spared the nerve in 80% of cases (vs. 84% in the mini-open approach). Maintaining innervation to paraspinal muscles, including the multifidus muscle (innervated by the medial branch nerve) is theorized to reduce atrophy.21 Measuring cross-sectional areas of multifidus muscles on magnetic resonance imaging (MRI) in patients having open versus percutaneous pedicle screw fixation demonstrated that percutaneous methods are associated with less paraspinal muscle atrophy when compared to open techniques. Furthermore, patients who underwent percutaneous fixation utilized less postoperative oral analgesics than patients who underwent the traditional open approach. Tissue trauma and muscle denervation may be contributing factors to patients’ chronic pain, and reducing local tissue trauma may prove beneficial in long-term pain control. More long-term data, however, is needed to support this theory.22
MISS Feasibility in Trauma
Several authors have reported on the feasibility and appropriateness of MISS as a treatment option for trauma patients. Wild et al.23 compared 5-year clinical and radiologic results of MISS versus open posterior surgery in the treatment of thoracolumbar vertebral body fractures in 21 patients. Estimated blood loss was significantly lower in the minimally invasive group. Surgical time, fluoroscopy time, and loss of correction were identical in both groups. Additionally, no significant difference was noted when comparing functional outcome scores. The authors concluded that minimally invasive posterior stabilization in trauma patients can be conducted with similar results of open methods. Minimally invasive techniques, however, had the distinct advantage of less blood loss. Similarly, Wang et al.24 analyzed the use of percutaneous pedicle screw fixation versus open pedicle screw fixation in the treatment of 38 cases of thoracolumbar fractures. Percutaneous instrumentation was associated with less blood loss, shorter operative times, shorter durations of hospital stay, and less postoperative pain compared to open fixation. Furthermore, there was no significant difference between the two groups in loss of kyphosis correction at final follow up.
Poelstra et al. presented the 1-year follow-up experience of treating 10 patients with multisystem injuries presenting with unstable complex thoracolumbar fractures. These patients were treated with damage-control spine surgery through minimally invasive techniques at a major level 1 trauma center. No patients could tolerate traditional open spinal stabilization because of hemodynamic instability. Brace stabilization was not possible due to fracture type, associated polytrauma injuries, or body habitus. Spinal stabilization was achieved within 48 hours after injury for all patients. All patients survived the trauma of surgery, and no revision surgery was necessary. Additionally, no screw malposition was found by postoperative computed tomography (CT) scans. Average EBL was 177 mL and average length of the surgical procedure was 95 minutes. The authors concluded that damage-control spinal stabilization
could be safely achieved with MISS techniques in polytrauma patients with unstable complex spinal injuries.6 MISS offers a valuable option that decreases the risks and morbidities commonly associated with open surgery.
could be safely achieved with MISS techniques in polytrauma patients with unstable complex spinal injuries.6 MISS offers a valuable option that decreases the risks and morbidities commonly associated with open surgery.