Disorders of communication and swallowing occur across the lifespan and may result from disruption of neurologic function and anatomical abnormalities of the head, neck, and respiratory system. Effective assessment and treatment involves collaboration across medical and rehabilitation disciplines. A discussion of normal function, incidence and prevalence, etiology, categories of impairment and treatment options is provided for each group of disorders.
Speech refers to motor acts that result in the production of sounds through the coordination of respiration, phonation, resonance, articulation, and prosody. Language is the symbolic organization of sounds into purposeful words and sentences to represent thought and includes linguistic elements such as morphology and syntax and paralinguistic elements of prosody.1 Cognition refers to mental processes and systems, such as attention, perception, memory, organization, and executive function.2
Successful communication requires intact neural pathways and peripheral structures to plan, modify, and process speech, language, and cognition. Neural activation patterns of communication and cognition are widespread and include structures and circuits of the cerebrum, the brainstem, the limbic system, and the cerebellum (Table 57–1).
Lobe | Location | Function | Impairment |
Frontal | Most anterior part of the brain | Language production Planning and initiation Judgment and reasoning Concentration Emotional range Inhibition Adaption to change Insight | Poor pragmatics Loss of flexible thinking Perseverations Poor focus or attention Emotional lability Inability to express language (Broca’s aphasia) Difficulty in problem solving |
Temporal | Laterally in cerebral hemispheres | Auditory sensation and perception Auditory comprehension Memory acquisition Visual perception Categorization of objects | Difficulty comprehending language (Wernicke’s aphasia) Prosopagnosia Disturbance with selective attention to what is seen and heard Memory loss |
Parietal | Between occipital lobe and central sulcus | Sensory integration: touch, pressure, pain, temperature, taste | Poor divided attention Anomia Alexia Agraphia Dyscalculia Poor kinesthetic awareness Unilateral neglect |
Occipital | Most posterior part of the brain | Visual processing Visual discrimination Visual association | Visual field cuts Difficulty locating objects in environment Difficulty reading or writing |
For example, in spoken language, humans require the temporal lobe for comprehension, the frontal lobe for production, the occipital lobe to visualize gestures and facial expression, and the parietal lobe for sensorimotor integration.3 The cerebellum and basal ganglia refine and coordinate speech movements, and the brainstem relays and receives the neural signals to and from the anatomy of speech and hearing4,5 (Table 57–2).
Structure | Location | Function | Impairment |
Thalamus | Center of forebrain | Relay of sensorimotor input to other areas of the brain Contributes to cortically mediated speech and language functions | Lower pain threshold Impaired contralateral somatic sensation |
Hypothalamus | Ventral to thalamus | Regulation of endocrine functions Hormonal system regulation Temperature regulation Blood volume Food and water intake Reproduction Circadian rhythm Wakefulness, activity level, metabolism Emotional expression | Difficulty with feeding and drinking Impaired control of body temperature regulation Impaired sleep-wake cycles Altered salt metabolism Difficulty expressing emotions Poor drive and initiation |
Hippocampus | Between thalamus and cerebral cortex | Important for recent working memory Inhibition of a habitually unsuccessful action Spatial navigation | Inability to form new memories (anterograde amnesia) Failure to remember spatial layouts or landmarks Topographic disorientation |
Amygdala | Located deep within medial temporal lobes of the brain | Involved in forming and storing memories associated with emotional events Regulation of emotions and motivation | Reduced safety awareness Poor recognition of risks Inability to attribute values to actions |
Basal ganglia | Includes caudate nucleus, putamen, and globus pallidus | Motor control and integration Regulation of muscle tone Regulation of drives, action execution, and cognitive function | Akinesia, akathisia Tardive dyskinesia Tremors, chorea, and ticks Disinhibition |
Disorders of speech, language, and cognition exist in isolation or in combination with one another and may be congenital or acquired. Speech disorders include dysarthria, apraxia of speech, voice disorders, and stuttering. Language disorders include impairments in auditory comprehension, reading comprehension, verbal expression, and written expression, as in child language disorders or aphasia. Cognitive communication disorders affect attention, memory, problem solving, reasoning, organizing, planning, and insight.
According to the National Institute of Deafness and Communication Disorders, one in six Americans has a disorder of communication. Apraxia of speech (AOS) was found in approximately 8% of a cohort of patients with neurogenic motor speech disorders; AOS typically co-occurs with aphasia.6–8 Childhood apraxia of speech (CAS) is estimated to occur in 1 to 2 per 1,000 members of the general population.9,10 Stuttering is present in an estimated 1% to 2.4% of children and 1% of adults.11–13 Voice disorders are reported by 7.5 million of Americans (National Institute on Deafness and Other Communication Disorders 2010a) and are more common in occupations that require frequent use of voice such as teachers.14
Language disorders of neurogenic origin occur in approximately 1 million individuals in the United States and are related to dementia in 2 million people.15 It has been reported that 8% of children in America present with developmental language disorders, and 10% have at least a moderate speech disorder.16 Disorders of cognitive communication occur in 1.4 million Americans annually following stroke; between 1 and 2 million trauma-related cases are seen in children.17,18
Dysarthria involves impairment of articulation, volume and pitch control, vocal quality (e.g., vocal hoarseness), resonance (e.g., hyper- or hyponasality), rate, or rhythm resulting from weakness, slowness, incoordination, and alteration in muscle tone.19 Dysarthria is classified by etiology, anticipated course, age at onset, and the speech process and/or functional component that is impaired.20 A widely used classification system of dysarthria based on perceptual characteristics and types of etiologies was developed at the Mayo Clinic21,22 (Table 57–3).
Type | Nervous System Involvement | Etiologies | Perceptual Characteristics |
Flaccid | Lower motor neuron | Brainstem stroke, muscular dystrophy, myasthenia gravis | Monoloudness, breathy phonation, hypernasality, nasal emission, imprecise articulation, monotone |
Spastic | Upper motor neuron | Stroke, traumatic brain injury (TBI), progressive supranuclear palsy | Reduced volume, strained-strangled phonation, low pitch, hypernasality, imprecise articulation, slow rate, reduced or equal and excess stress |
Hyperkinetic | Extrapyramidal tract, basal ganglia | Huntington’s disease, cerebral palsy | Excess loudness, strained phonation, phonation breaks, hypernasality, imprecise articulation, variable rate |
Hypokinetic | Extrapyramidal tract, substantia nigra | Parkinson’s disease | Low volume, breathy phonation, monotone, imprecise articulation, excess rate |
Ataxic | Cerebellum | Ataxia syndrome, cerebellar stroke | Excess loudness, pitch variations, excess and equal stress, variable rate, irregular articulatory breakdown |
Mixed | Upper and lower motor neurons | Multiple system atrophy, multiple sclerosis | Combinations of characteristics, e.g., spastic/flaccid, spastic/ataxic, hypokinetic/spastic/ataxic |
AOS is an articulatory programming disorder with impairment of the positioning and sequencing of speech musculature, absent weakness, slowness, or incoordination.22,23 The hallmarks of AOS include effortful groping with attempted self-correction, persistent dysprosody (abnormal rhythm, stress, and/or intonation), articulatory inconsistency on repeated productions, and difficulty initiating utterances.24 Stuttering is a disorder of fluency and typically manifests in repetition, prolongation, or blockage of speech sounds.12 A person who stutters may also develop secondary behaviors in response to dysfluency, such as extraneous facial or head and neck movements.25 A voice disorder is characterized by constrained vocal quality, loudness, pitch, or loss of voice along with maladaptive compensatory strategies. Perceptual voice deviations may also be present in dysarthria.
Aphasia is a language disorder characterized by impairments in auditory comprehension, verbal expression, reading comprehension, and/or written expression. The nature and extent of aphasia depend on the site and size of the lesion. The classic stroke-aphasia syndromes are defined by locus of damage and frequently co-occurring clusters of impairments in fluency, auditory comprehension, repetition, and naming26 (Table 57–4).
Aphasia Subtype | Fluency | Auditory Comprehension | Repetition | Word Retrieval |
Broca | Impaired | Intact or impaired | Impaired | Impaired |
Wernicke | Intact | Impaired | Impaired | Impaired |
Conduction | Intact | Intact | Impaired | Intact or impaired |
Anomic | Intact | Intact | Intact | Impaired |
Global | Impaired | Impaired | Impaired | Impaired |
Transcortical motor | Impaired | Intact or impaired | Intact | Impaired |
Transcortical sensory | Intact | Impaired | Intact | Impaired |
Mixed transcortical | Impaired | Impaired | Intact | Impaired |
The classification of aphasias is therefore based on a thorough evaluation that assesses the fluency, comprehensions, and repetition of language (Fig. 57–1).
Subtypes of aphasia are further characterized by fluency, word-finding ability, auditory comprehension, and speech fluency. These clinical assessments are also helpful in localizing the lesion of injury (Table 57–5).
Type | Lesion Localization | Major Clinical Characteristics |
Broca’s | Lateral frontal, suprasylvian area | Nonfluent, halted, effortful speech Agrammatism Imprecise articulation Phonemic paraphasias |
Wernicke’s | Posterior third of superior temporal gyrus | Fluent jargon speech with normal prosody Press-of-speech (speaking rapidly without pausing, interrupting others) Poor auditory comprehension and repetition |
Conduction | Supramarginal gyrus, left insula, auditory cortex | Fluent output with average phrase length Word-finding pauses, phonemic paraphasias Poor repetition |
Anomic | Angular gyrus, second temporal gyrus | Word-finding problems Verbal output: use of circumlocutions and nonspecific terms |
Transcortical motor | Anterior frontal paramedian, anterosuperior to Broca’s area | Impaired initiation of verbal output Short phrase length |
Transcortical sensory | Posterior parietotemporal area, sparing Wernicke’s area | Significant anomia and poor auditory comprehension but good repetition skills Semantic paraphasias in verbal output and empty quality to discourse |
Global | Large perisylvian area | Profound anomia with virtually no speech output Very poor auditory comprehension Stereotypic utterances |
Subcortical | Internal capsule (white matter pathways), basal ganglia, thalamus | Thalamic aphasia: impaired auditory comprehension and confrontation naming Nonthalamic aphasia: impaired speech fluency, grammatical and phonologic errors Repetition is preserved |
The taxonomy of symptoms associated with each syndrome is thought to be related to the disruption of vascular supply to structures in the immediate locus of the infarct as well as hypoperfusion in the surrounding areas.27 In fluent aphasia, prosody is preserved, whereas in nonfluent aphasia, speech output is effortful and limited.28 Preserved repetition is a defining characteristic of the transcortical aphasias.29,30 In addition to the classic aphasia syndromes, other diagnostic entities include the subcortical aphasias and primary progressive aphasia, a neurodegenerative language condition.31–33
Speech disorders can be due to neurologic or structural etiologies. Dysarthria may be caused by disorders of or damage to the central or peripheral nervous system, the neuromuscular junction, or the muscular system.21,22,34 AOS occurs most frequently after left hemisphere stroke,35–37 although it may also result from progressive neurologic disease.38–40 Childhood apraxia of speech (CAS) is present from birth and is thought to include a genetic component.41,42 Developmental stuttering typically results from a combination of genetic and environmental factors.43 In rare cases, acquired stuttering may be a symptom of brain injury, such as stroke or tumor.44,45 Voice disorders may result from damage to the central or peripheral nervous system as well as congenital or acquired structural deficits.
The most common cause of aphasia is stroke in the lateral aspects of the left cerebral hemisphere, such as a middle cerebral artery infarct affecting Broca’s or Wernicke’s area.46,47 Although rare, cases of aphasia subsequent to right hemisphere stroke have been reported.48,49 Aphasia may also present when a stroke originating in a subcortical structure is related to hypoperfusion in the cerebral cortex50 (Fig. 57–2).
Figure 57–2
Location of some of the areas in the categorical hemisphere that are concerned with language functions. Wernicke’s area is in the posterior end of the superior temporal gyrus and is concerned with comprehension of auditory and visual information. It projects via the arcuate fasciculus to Broca’s area in the frontal lobe. Broca’s area processes information received from Wernicke’s area into a detailed and coordinated pattern for vocalization and then projects the pattern via a speech articulation area in the insula to the motor cortex, which initiates the appropriate movements of the lips, tongue, and larynx to produce speech. (Reproduced with permission from Learning, Memory, Language, & Speech. In: Barrett KE, Barman SM, Boitano S, Brooks HL, eds. Ganong’s Review of Medical Physiology, 25e New York, NY: McGraw-Hill; 2016.)
Cognitive communicative disorders may result from discrete or diffuse brain damage. Progressive neurologic diseases such as dementia and primary progressive aphasia involve gradual deterioration of cognitive functions, whereas TBI is associated with variable severity and presentation.51–53
Speech, language, and cognitive communication disorders may result from iatrogenic causes, as in the case of voice disorders subsequent to chemoradiation or surgery for head and neck cancer.54 Cognitive communication impairments may also be related to substance abuse or exposure to environmental toxins.55–57 On occasion, the etiology of speech, language, and cognitive communication impairments remains unknown.
Speech-language pathologists administer screening and formal tests to elicit signs of communication impairments, such as imprecise speech articulation during sentence repetition, trouble following complex instructions, or difficulty naming pictured objects. Patient-reported symptoms inform the diagnosis; for example, an acute onset of speech or language deficits is characteristic of stroke, whereas a gradual onset suggests progressive neurologic disease (Table 57–6).
Language Area | Description |
Auditory comprehension | The ability to listen to and process information presented verbally. Includes the understanding of interrogatives (yes-no, “wh-”), literal and figurative language, words, phrases, sentences, paragraphs, stories, and conversation; also includes the ability to follow commands that increase in both length and complexity |
Verbal repetition | The ability to repeat what one hears |
Automatic speech | The verbalization of commonly used sequences of language and rote phrases that occur without much conscious effort of the individual (e.g., the days of the week or counting to 10) |
Word recall | The ability to name objects and pictures during structured confrontation naming as well as at the conversational level |
Fluency | The ability to produce an uninterrupted phrase-length utterance, typically more than four words in length; involves the smoothness or flow with which the sounds, syllables, words, and phrases are joined together |
Discourse ability | The ability to converse, discuss topics, retell a story or a joke, comment, ask and answer questions, etc. |
Grammatical use | The ability to organize words and sentences into a logical structure based on the rules of syntax for that particular language |
Written expression | Includes copying, writing to dictation, self-generated writing, written spelling, and drawing |
Reading comprehension | Includes word- and sentence-level comprehension, oral reading, and oral spelling |
Pragmatics (social communication) | Includes initiating conversation, taking turns during a discussion, using appropriate language in social situations, etc. |
Nonverbal communication | Gestures, facial expressions, pointing, eye contact, etc. |
Disorders of speech and language are distinct diagnostic entities, although they do co-occur.20 Dysarthria is a neurogenic speech disorder, whereas other speech disorders are due to structural etiologies, such as head and neck cancer or cleft palate. Voice disorders, including abnormalities of vocal quality due to vocal fold lesions or vocal fold motion impairments (e.g., hoarseness, roughness) are also separate diagnostic entities. However, perceptual voice deviations (e.g., vocal hoarseness, strain, low volume) may be considered within the realm of dysarthria and may even be pathognomonic of certain etiologies.
Furthermore, dysarthria is characterized by predictable speech sound errors resulting from weakness, slowness, incoordination, or abnormal muscle tone, in contrast to irregular articulatory breakdowns in apraxia of speech in the setting of intact muscle function20,22,58,59 (Table 57–7). Finally, the content of a person’s message is generally preserved in the motor speech disorders of dysarthria and apraxia of speech but is impaired in cases of aphasia.
Speech-language pathologists perform speech/oral motor examinations to assess the respiratory mechanism, laryngeal mechanism, velum/pharynx, tongue, lips/face/teeth, and jaw. Formal tests, such as the Frenchay Dysarthria Test or the Apraxia Battery for Adults-2 are often used.60,61 Speech intelligibility measures include the Assessment of Intelligibility of Dysarthric Speech.62 Perceptual scales, such as the Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V), may be used to rate voice characteristics.63 Objective acoustic measurements may be obtained using specialized equipment and software. Voice function is assessed by endoscopic viewing of the larynx and surrounding structures during speech and nonspeech tasks; the vibration of the vocal folds is assessed under rapid pulses of light, or stroboscopy.
Comprehensive language batteries, such as the Western Aphasia Battery and the Boston Diagnostic Aphasia Examination, provide a survey of all language modalities.64,65 Supplementary tests, such as the Boston Naming Test-2 and the Reading Comprehension Battery for Aphasia, may be administered to probe specific deficit areas.66,67 The Montreal Cognitive Assessment, a brief screening assessment, or the Ross Information Processing Assessment, a more extensive battery, can be administered to examine orientation, attention, short-term memory, and reasoning.68,69 Specialized questionnaires, such as the Communication Confidence Rating Scale for Aphasia and the Quality of Communication Life Scale, probe the impact of communication disorders on quality of life.70,71 The clinical assessment of communication and cognition is supplemented by reports from other disciplines, including neurology, radiology, neuropsychology, and otolaryngology, among others.
Management goals are individualized and based on test performance and patient-family goals. Therapy can be delivered in individual and/or group sessions and focuses on restoration, compensation, or a combination of the two. Many standardized therapy protocols are available, such as Melodic Intonation Therapy for Broca’s aphasia and the Lee Silverman Voice Treatment for dysarthria in Parkinson’s disease.72–74 In cases of severe impairment, oral/verbal communication is supplemented or replaced by augmentative and alternative communication (AAC) in the form of electronic devices or communication boards.75
In conjunction with behavioral therapy, medical interventions have been shown to improve communication.76 Protocols employing repetitive transcranial magnetic stimulation (rTMS) may improve naming in individuals with nonfluent aphasia by suppression of the overactive right hemisphere homologues.77–79 Additionally, medical therapies to restore perfusion to ischemic tissue, such as carotid stenting, endarterectomy, endovascular therapy, thrombolysis, and temporarily induced blood pressure elevation, result in improvements on cognitive-language tasks.80–82
Speech, language, and cognition are fundamental to the production and comprehension of communication. Any disruption in the neurophysiology and anatomy underlying these processes may result in a communication disorder. Several methods of treatment are available to target the specific deficits documented by clinical evaluation and patient report.
Swallowing is a highly complex neuromuscular sequence of events that requires precise coordination of structures in the aerodigestive tract to safely propel a bolus from the oral cavity into the stomach while protecting the airway. This process can be divided into four stages, demarcated by the location of the bolus, and varies depending on bolus consistency83 (Fig. 57–3).
Figure 57–3
Sequence of events during the oropharyngeal phase of swallowing. (Reprinted with permission from DeMeester TR, Stein HJ, Fuchs KH. Physiologic diagnostic studies. In: Zuidema GD, Orringer MB, eds. Shackelford’s surgery of the alimentary tract. 3rd ed., vol. I. Philadelphia, PA: Saunders; 1991: 95. Copyright Elsevier.)
During drinking, the bolus is held in the anterior oral cavity while the posterior tongue and soft palate prevent premature spillage into the pharynx (oral preparatory stage). Then, at the onset of the oral propulsive stage, the anterior tongue contacts the hard palate and moves posteriorly, propelling the bolus past the fauces and into the oropharynx.
In the case of a solid bolus, there are two distinct oral stages. During stage 1 transport, coordinated motions of the tongue and cheek move the bolus to the lower teeth. The bolus is then broken down by saliva and mastication in preparation for the pharyngeal stage. Stage 2 transport is initiated by the lingual transfer of the prepared bolus to the oropharynx by the same process as delineated in the oral propulsive state for liquids (Fig. 57–4).
The pharyngeal stage involves four valves that direct the bolus through the pharynx and prevent it from entering the airway.84 The first valve, the velopharynx, is composed of the soft palate and pharyngeal walls; it seals the nasopharynx and enables generation of adequate pressures to propel the bolus. The second valve, the larynx, has three levels of protection that prevent the bolus from entering the airway: the closure of the true vocal folds, the approximation of the false vocal folds, and epiglottic inversion. The third valve, the hypopharynx, generates the pressure that drives the bolus through the pharynx. The fourth and final valve is the upper esophageal sphincter, which relaxes during the swallow, allowing the passage of the bolus into the esophagus. During the esophageal stage, peristalsis and gravity move the bolus through the lower esophageal sphincter into the stomach (Table 57–8).
Action | Muscle | Function | Cranial Nerve Innervation |
Oral-Preparatory Phase: Prepares Food for Swallowing (∼15–30 chews) | |||
Mouth opens | Mylohyoid Geniohyoid Lateral pterygoid | Depresses jaw Depresses jaw Protrudes jaw | Trigeminal (CN V) |
Bolus enters; labial seal on cup or utensil | Medial pterygoid Orbicularis oris Zygomatic | Elevates jaw Closes mouth Draws angles of mouth laterally | Facial (CN VII) |
Tongue is cupped to hold liquid; tongue moves solids to molars for chewing | Genioglossus Styloglossus Palatoglossus | Retracts and protrudes tongue Pulls tongue up and back Elevates tongue | Hypoglossal (CN XII) |
Jaws open and close to grind food | Masseter Temporalis | Closes, lifts, and raises jaw Elevates and protrudes jaw | Trigeminal (CN V) |
Saliva helps bolus form | (Salivary glands) | — | Glossopharyngeal (CN IX) |
Cheeks flatten to keep food in | Risorius Buccinator | Retracts lips at corner Draws corners of mouth laterally, compresses lips against teeth | Facial (CN VII) |
Taste and sensation | — | Anterior two-thirds of tongue | Trigeminal (CN V) |
— | Posterior one-third of tongue | Glossopharyngeal (CN IX) | |
Oral Phase: Posterior Oral Transit of Bolus to Pharynx (∼8 sec) | |||
Posterior tongue drops | Mylohyoid Genioglossus Hypoglossus | Depresses jaw Depresses tongue Pulls sides of tongue down | Trigeminal (CN V) Vagus (CN X) Hypoglossal (CN XII) |
Tongue tip elevates | Superior longitudinal | Pulls tongue tip upward | Vagus (CN X) |
Tongue squeezes bolus against hard palate in a sweeping motion | Palatoglossus Hypoglossus | Elevates tongue Pulls sides of tongue down | Hypoglossal (CN XII) |
Velum begins to elevate | Levator veli palatini Uvular | Elevates velum Shortens and lifts velum | Vagus (CN X) |
Pharyngeal walls constrict | Superior, middle, and inferior constrictors | Constrict pharynx | Glossopharyngeal (CN IX) and vagus (CN X) |
Lips seal tightly | Orbicularis oris | Pull lips together | Facial (CN XII) |
Pharyngeal Stage: Reflexive Swallow Begins (∼1–2 sec) | |||
Bolus contacts faucial pillars, soft palate, and posterior tongue base | — | Reflexive swallow | — |
Velum continues to elevate | — | — | Vagus (CN X) |
Vocal folds adduct | Lateral cricoarytenoid Circular cricoarytenoid | Close vocal folds Close vocal folds | — |
Hyoid bone and larynx move up and forward | Digastric Geniohyoid Hypoglossus Stylopharyngeus Geniohyoid | Raises hyoid bone up and forward Elevates larynx Elevates hyoid bone Elevates pharynx Elevates larynx | Glossopharyngeal (CN IX) Trigeminal (CN X) |
Epiglottic inversion; the epiglottis descends to cover the laryngeal opening (aditus) | Aryepiglottic muscles | Invert epiglottis | Vagus (CN X) |
Inferior constrictor of cricopharyngeal muscle relaxes | — | — | — |
Pharynx contracts | Superior, middle, and inferior constrictors | — | Glossopharyngeal (CN IX) and vagus (CN X) |
Esophageal Stage: Bolus Is Moved toward Stomach | |||
Peristaltic contractions | — | Downward directed (wavelike) | Vagus (CN X) |
Food moves down to esophagus | Esophageal muscles | — | — |
Muscles of oral and pharyngeal cavities return to resting position | Tensor veli palatini Palatoglossus Palatopharyngeal Genioglossal | Tenses velum Pulls velum down Depresses velum Retracts tongue | Trigeminal (CN V) — Spinal accessory (CN XI) Vagus (CN X) |