Role of Systemic and Local Antibiotics in the Treatment of Open Fractures




The orthopedic community has learned much about the treatment of open fractures from the tremendous work of Ramon Gustilo, Michael Patzakis, and others; however, open fractures continue to be very difficult challenges. Type III open fractures continue to be associated with high infection rates. Some combination of systemic and local antibiotics may be most appropriate in these high-grade open fractures. Further research is still necessary in determining optimal systemic antibiotic regimens as well as the role of local antibiotics. Any new discoveries related to novel systemic antibiotics or local antibiotic carriers will need to be evaluated related to cost.


Key points








  • Systemic antibiotics have been shown to decrease infection rates after open fracture.



  • Controversy continues to exist over the ideal systemic antibiotic prophylaxis, particularly for type III open fractures.



  • Local antibiotic delivery, although not new, is an area of renewed interest.



  • Local antibiotics allow delivery of high concentrations of antibiotic without systemic toxicity.



  • Many modes of local antibiotic delivery currently exist.


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Oct 6, 2017 | Posted by in ORTHOPEDIC | Comments Off on Role of Systemic and Local Antibiotics in the Treatment of Open Fractures
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