Psoriatic Arthritis




For years psoriatic arthritis was considered part of the spectrum of rheumatoid arthritis. The classification of psoriatic arthritis as a “rheumatoid variant” persists today. However, the radiographic manifestations, along with clinical and laboratory data, establish psoriatic arthritis as a separate and distinct articular disorder. Psoriatic arthritis occurs in 5 to 8 percent of patients with severe and longstanding psoriatic skin disease. However, the arthropathy may coincide with or antedate the appearance of skin disease. In these patients, the radiographic examination becomes the determinate diagnostic study. The distinguishing radiographic features are as follows:



  • 1.

    Fusiform soft tissue swelling


  • 2.

    Maintenance of normal mineralization


  • 3.

    Dramatic joint space loss


  • 4.

    Bone proliferation


  • 5.

    “Pencil-in-cup” erosions


  • 6.

    Bilateral asymmetrical distribution


  • 7.

    Distribution primarily in hands, feet, sacroiliac (SI) joints, and spine, in decreasing order of frequency



Although psoriatic arthritis differs from rheumatoid arthritis radiographically in many ways, the most significant difference is the presence of bone proliferation.


The hands


The hands are most commonly involved in psoriatic arthritis. Although there may be nonspecific periarticular fusiform soft tissue swelling, there may be soft tissue edema beyond the joint, causing swelling of the entire digit in approximately 25 percent of patients. This dactylitis is described as sausage-like or resembling a cocktail hot dog ( Fig. 10-1 ) on clinical examination and is highly specific for a spondyloarthropathy. Juxta-articular osteoporosis may occur in the early phases of the disease; however, it is transient. Normal mineralization is usually maintained even in the presence of severe erosive disease. Erosions occur initially at the margins of the joint but with time progress to involve the central area ( Fig. 10-2 ). The erosion may become so extensive, destroying so much of the underlying bone, that the joint space may actually appear to be widened. The ends of the bones may become pointed, appearing as if destroyed by a pencil sharpener. The bone articulating with the pointed bone may become saucerized through erosion, producing the classic “pencil-in-cup” or “cup-and-saucer” appearance ( Fig. 10-3 ). Erosions may also be appreciated involving the distal tufts of the fingers producing a pattern of acro-osteolysis.




Figure 10-1


Posteroanterior (PA) view of the hand showing classic radiographic changes of psoriatic arthritis: sausage-like swelling of the first, second, and third digits; normal mineralization; severe erosive changes creating the appearance of widened joint spaces of the second and third DIP joints; solid periosteal new bone added to the middle phalanx of third digit, widening the shaft; and fluffy new bone apposition adjacent to erosive changes ( arrows ).



Figure 10-2


A, Marginal erosions of the DIP joint. B, Marginal erosions have progressed to involve the central area of the PIP joint. Note ankylosis of DIP joint.



Figure 10-3


PA view of fourth digit in a patient with psoriasis demonstrating a classical “pencil-in-cup” deformity. Notice sausage-like swelling.


Bone proliferation is one of the most important features of psoriatic arthritis and is almost always present in some form. Bone proliferation takes place in four areas: adjacent to erosions, along shafts, across joints, and at tendinous and ligamentous insertions. The bone proliferation adjacent to erosive changes is observed as irregular excrescences with a spiculated, frayed, or fluffy appearance. With time these excrescences become well-defined bone ( Fig. 10-4 ). Bone proliferation may be observed along shafts as a periostitis ( Fig. 10-5 ). Initially it is exuberant and fluffy in appearance. Eventually it becomes solid new bone along the shaft of the phalanx, causing the widened appearance to the phalanx (see Fig. 10-1 ). Bone ankylosis across a joint is a common occurrence in distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints (see Fig. 10-2 and 10-6 ). Bone proliferation occurring at tendinous and ligamentous insertions in the hand and wrist will be seen as a continuation of the periosteal response.




Figure 10-4


Bone proliferation ( arrows ) adjacent to erosive changes. Some excrescences are well defined, whereas others are more irregular in appearance.



Figure 10-5


Periostitis ( arrows ) along the shafts of bones.



Figure 10-6


Bone ankylosis of the second and fifth DIP joints.


In the hand, psoriatic arthritis has three different patterns of distribution. The first pattern is primarily DIP and PIP involvement, with relative sparing of the metacarpophalangeal (MCP) and carpal joints ( Fig. 10-7 ). The second pattern is ray involvement, wherein one to three fingers will be involved in all joints while the other fingers are spared. The carpal bones may or may not be involved ( Fig. 10-8 ). The third pattern is similar to rheumatoid arthritis. In this distribution, other features will distinguish psoriatic arthritis from rheumatoid arthritis ( Fig. 10-9 ). There is usually DIP involvement or evidence of bone proliferation ( Fig. 10-10 ).




Figure 10-7


Involvement of IP joints with relative sparing of MCP joints. There are “pencil-in-cup” erosive changes involving the IP joint of the thumb and the DIP joint of the second and fifth digit.



Figure 10-8


PA view of the hand in patient with psoriasis. The fifth digit is involved in all joints, including the carpometacarpal joint, with erosion and bone production.

Jan 26, 2019 | Posted by in RHEUMATOLOGY | Comments Off on Psoriatic Arthritis

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