Pediatrics: Juvenile Idiopathic Arthritis
JIA is the most common rheumatic disease of childhood
Diagnosis should fulfill the following criteria:
occur before age 16 years
persist for at least 6 weeks
diagnosis of exclusion
JIA affects bone and joints. It can lead to overgrowth, undergrowth, or aberrant growth. Possible anomalies related to JIA include micrognathia, leg length discrepancy, and hip dysplasia.
Indicators of poor outcome include
Greater severity and extension at the onset of disease
Symmetrical disease
Early wrist and hip involvement
Serologic evidence of RF
Persistent active disease
Early radiographic changes
There are seven subtypes of JIA:
Systemic arthritis
Oligoarthritis
RF-negative polyarthritis
RF-positive arthritis
Psoriatic arthritis
Enthesitis-related arthritis
Undifferentiated arthritis
KEY POINTS
Systemic Arthritis
Diagnosis requires both
Presence of arthritis
Arthritis preceded by fever (periodic spike to 102° F) or at least 2 weeks of fever
One or more of the following signs:
Evanescent salmon-colored rash
Lymphadenopathy
Hepatomegaly
Splenomegaly
Serositis
A small subset of children can develop macrophage activation syndrome, a life-threatening complication.
Half of the patients with systemic JIA follow a relapsing-remitting course with good long-term prognosis.
Another half have unremitting course with poor clinical and functional prognosis leading to joint destruction.