Osteochondritis dissecans (OCD) can cause knee pain and dysfunction in children. The etiology of OCD remains unclear; theories on causes include inflammation, ischemia, ossification abnormalities, genetic factors, and repetitive microtrauma. Most OCD lesions in skeletally immature patients will heal with nonoperative treatment. The success of nonoperative treatment decreases once patients reach skeletal maturity. The goals of surgical treatment include maintenance of articular cartilage congruity, rigid fixation of unstable fragments, and repair of osteochondral defects with cells or tissues that can adequately replace lost or deficient cartilage. Unsalvageable OCD lesions can be treated with various surgical techniques.
High-quality evidence for the optimal evaluation and management of pediatric OCD lesions remains sparse, and continued research is needed.
High-quality evidence for the optimal evaluation and management of pediatric OCD lesions remains sparse, and continued research is needed.
Although the precise etiology of OCD is unclear, it is known that if these lesions are left untreated and fail to heal appropriately, they have a high potential of contributing to the development of future osteoarthritis.
References
- 1. Hughston J.C., Hergenroeder P.T., and Courtenay B.G.: Osteochondritis dissecans of the femoral condyles. J Bone Joint Surg Am 1984; 66: pp. 1340-1348
- 2. Linden B.: The incidence of osteochondritis dissecans in the condyles of the femur. Acta Orthop Scand 1976; 47: pp. 664-667
- 3. Kessler J.I., Nikizad H., Shea K.G., et al: The demographics and epidemiology of osteochondritis dissecans of the knee in children and adolescents. Am J Sports Med 2014; 42: pp. 320-326
- 4. Hefti F., Beguiristain J., Krauspe R., et al: Osteochondritis dissecans: a multicenter study of the European Pediatric Orthopedic Society. J Pediatr Orthop B 1999; 8: pp. 231-245
- 5. Aichroth P.: Osteochondritis dissecans of the knee. A clinical survey. J Bone Joint Surg Br 1971; 53: pp. 440-447
- 6. Cahill B.R.: Osteochondritis Dissecans of the Knee: Treatment of Juvenile and Adult Forms. J Am Acad Orthop Surg 1995; 3: pp. 237-247
- 7. Clanton T.O., and DeLee J.C.: Osteochondritis dissecans. History, pathophysiology and current treatment concepts. Clin Orthop Relat Res 1982; undefined: pp. 50-64
- 8. Glancy G.L.: Juvenile osteochondritis dissecans. Am J Knee Surg 1999; 12: pp. 120-124
- 9. Kocher M.S., and Micheli L.J.: The pediatric knee: evaluation and treatment. In Insall J.N., and Scott W.N. (eds): Surgery of the knee, 3rd edition. New York: Churchill Livingstone, 2001. pp. 1356-1397
- 10. Ganley T.J., and Flynn J.M.: Osteochondritis dissecans. In (eds): , 4th edition. Philadelphia: Elsevier, 2006. pp. 1234-1241
- 11. Crawford D.C., and Safran M.R.: Osteochondritis dissecans of the knee. J Am Acad Orthop Surg 2006; 14: pp. 90-100
- 12. Shea K.G., Jacobs J.C., Carey J.L., et al: Osteochondritis dissecans knee histology studies have variable findings and theories of etiology. Clin Orthop Relat Res 2013; 471: pp. 1127-1136
- 13. Mubarak S.J., and Carroll N.C.: Familial osteochondritis dissecans of the knee. Clin Orthop Relat Res 1979; undefined: pp. 131-136
- 14. Stougaard J.: Familial Occurrence of Osteochondritis Dissecans. J Bone Joint Surg Br 1964; 46: pp. 542-543
- 15. König F.: Ueber freie Körper in den Gelenken. Dtsch Z Chir 1887; 27: pp. 90-109
- 16. Ribbing S.: The hereditary multiple epiphyseal disturbance and its consequences for the aetiogenesis of local malacias–particularly the osteochondrosis dissecans. Acta Orthop Scand 1955; 24: pp. 286-299
- 17. Green W.T., and Banks H.H.: Osteochondritis dissecans in children. J Bone Joint Surg Am 1953; 35-A: pp. 26-47
- 18. Linden B., and Telhag H.: Osteochondritis dissecans. A histologic and autoradiographic study in man. Acta Orthop Scand 1977; 48: pp. 682-686
- 19. Chiroff R.T., and Cooke C.P.: Osteochondritis dissecans: a histologic and microradiographic analysis of surgically excised lesions. J Trauma 1975; 15: pp. 689-696
- 20. Koch S., Kampen W.U., and Laprell H.: Cartilage and bone morphology in osteochondritis dissecans. Knee Surg Sports Traumatol Arthrosc 1997; 5: pp. 42-45
- 21. Reddy A.S., and Frederick R.W.: Evaluation of the intraosseous and extraosseous blood supply to the distal femoral condyles. Am J Sports Med 1998; 26: pp. 415-419
- 22. Rogers W.M., and Gladstone H.: Vascular foramina and arterial supply of the distal end of the femur. J Bone Joint Surg Am 1950; 32: pp. 867-874
- 23. Toth F., Nissi M.J., Ellermann J.M., et al: Novel application of magnetic resonance imaging demonstrates characteristic differences in vasculature at predilection sites of osteochondritis dissecans. Am J Sports Med 2015; 43: pp. 2522-2527
- 24. Olstad K., Hendrickson E.H., Carlson C.S., et al: Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans. Osteoarthritis Cartilage 2013; 21: pp. 730-738
- 25. Martel G., Kiss S., Gilbert G., et al: Differences in the vascular tree of the femoral trochlear growth cartilage at osteochondrosis-susceptible sites in foals revealed by SWI 3T MRI. J Orthop Res 2016; undefined:
- 26. Gans I., Sarkissian E.J., Grant S.F., et al: Identical osteochondritis dissecans lesions of the knee in sets of monozygotic twins. Orthopedics 2013; 36: pp. e1559-e1562
- 27. Hammett R.B., and Saxby T.S.: Osteochondral lesion of the talus in homozygous twins—the question of heredity. Foot Ankle Surg 2010; 16: pp. e55-e56
- 28. Kenniston J.A., Beredjiklian P.K., and Bozentka D.J.: Osteochondritis dissecans of the capitellum in fraternal twins: case report. J Hand Surg Am 2008; 33: pp. 1380-1383
- 29. Mackie T., and Wilkins R.M.: Case report: Osteochondritis dissecans in twins: treatment with fresh osteochondral grafts. Clin Orthop Relat Res 2010; 468: pp. 893-897
- 30. Mei-Dan O., Mann G., Steinbacher G., et al: Bilateral osteochondritis dissecans of the knees in monozygotic twins: the genetic factor and review of the etiology. Am J Orthop (Belle Mead NJ) 2009; 38: pp. E152-E155
- 31. Woods K., and Harris I.: Osteochondritis dissecans of the talus in identical twins. J Bone Joint Surg Br 1995; 77: pp. 331
- 32. Fonseca A.S., Keret D., and MacEwen G.D.: Familial osteochondritis dissecans. Orthopedics 1990; 13: pp. 1259-1262
- 33. Fraser W.N.C.: Familial Osteochondritis Dissecans. J Bone Joint Surg Br 1966; 48-B: pp. 598
- 34. Pick M.P.: Familial osteochondritis dissecans. J Bone Joint Surg Br 1955; 37-B: pp. 142-145
- 35. Roberts N., and Hughes R.: Osteochondritis dissecans of the elbow joint; a clinical study. J Bone Joint Surg Br 1950; 32-B: pp. 348-360
- 36. White J.: Osteochondritis dissecans in association with dwarfism. J Bone Joint Surg Br 1957; 39-B: pp. 261-267
- 37. Zellweger H., and Ebnother M.: A familial skeletal disorder with multilocular, aseptic bone necrosis, and with osteochondritis dissecans in particular. Helv Paediatr Acta 1951; 6: pp. 95-111
- 38. Jacobi M., Wahl P., Bouaicha S., et al: Association between mechanical axis of the leg and osteochondritis dissecans of the knee: radiographic study on 103 knees. Am J Sports Med 2010; 38: pp. 1425-1428
- 39. Fairbank H.A.T.: Osteochondritis dissecans. Br J Surg 1933; 21: pp. 67-82
- 40. Flynn J.M., Kocher M.S., and Ganley T.J.: Osteochondritis dissecans of the knee. J Pediatr Orthop 2004; 24: pp. 434-443
- 41. Hashimoto Y., Yoshida G., Tomihara T., et al: Bilateral osteochondritis dissecans of the lateral femoral condyle following bilateral total removal of lateral discoid meniscus: a case report. Arch Orthop Trauma Surg 2008; 128: pp. 1265-1268
- 42. Deie M., Ochi M., Sumen Y., et al: Relationship between osteochondritis dissecans of the lateral femoral condyle and lateral menisci types. J Pediatr Orthop 2006; 26: pp. 79-82
- 43. Twyman R.S., Desai K., and Aichroth P.M.: Osteochondritis dissecans of the knee. A long-term study. J Bone Joint Surg Br 1991; 73: pp. 461-464
- 44. Linden B.: Osteochondritis dissecans of the femoral condyles: a long-term follow-up study. J Bone Joint Surg Am 1977; 59: pp. 769-776
- 45. Madry H., van Dijk C.N., and Mueller-Gerbl M.: The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc 2010; 18: pp. 419-433
- 46. Madry H.: The subchondral bone: a new frontier in articular cartilage repair. Knee Surg Sports Traumatol Arthrosc 2010; 18: pp. 417-418
- 47. Pape D., Filardo G., Kon E., et al: Disease-specific clinical problems associated with the subchondral bone. Knee Surg Sports Traumatol Arthrosc 2010; 18: pp. 448-462
- 48. Milgram J.W.: Radiological and pathological manifestations of osteochondritis dissecans of the distal femur. A study of 50 cases. Radiology 1978; 126: pp. 305-311
- 49. Wall E.J., Polousky J.D., Shea K.G., et al: Novel radiographic feature classification of knee osteochondritis dissecans: a multicenter reliability study. Am J Sports Med 2015; 43: pp. 303-309
- 50. Kocher M.S., DiCanzio J., Zurakowski D., et al: Diagnostic performance of clinical examination and selective magnetic resonance imaging in the evaluation of intraarticular knee disorders in children and adolescents. Am J Sports Med 2001; 29: pp. 292-296
- 51. Samora W.P., Chevillet J., Adler B., et al: Juvenile osteochondritis dissecans of the knee: predictors of lesion stability. J Pediatr Orthop 2012; 32: pp. 1-4
- 52. Zbojniewicz A.M., Stringer K.F., Laor T., et al: Juvenile Osteochondritis Dissecans: Correlation Between Histopathology and MRI. AJR Am J Roentgenology 2015; 205: pp. W114-W123
- 53. De Smet A.A., Ilahi O.A., and Graf B.K.: Untreated osteochondritis dissecans of the femoral condyles: prediction of patient outcome using radiographic and MR findings. Skeletal Radiol 1997; 26: pp. 463-467
- 54. Bohndorf K.: Osteochondritis (osteochondrosis) dissecans: a review and new MRI classification. Eur Radiol 1998; 8: pp. 103-112
- 55. O’Connor M.A., Palaniappan M., Khan N., et al: Osteochondritis dissecans of the knee in children. A comparison of MRI and arthroscopic findings. J Bone Joint Surg Br 2002; 84: pp. 258-262
- 56. Heywood C.S., Benke M.T., Brindle K., et al: Correlation of magnetic resonance imaging to arthroscopic findings of stability in juvenile osteochondritis dissecans. Arthroscopy 2011; 27: pp. 194-199
- 57. Pill S.G., Ganley T.J., Milam R.A., et al: Role of magnetic resonance imaging and clinical criteria in predicting successful nonoperative treatment of osteochondritis dissecans in children. J Pediatr Orthop 2003; 23: pp. 102-108
- 58. Wall E.J., Vourazeris J., Myer G.D., et al: The healing potential of stable juvenile osteochondritis dissecans knee lesions. J Bone Joint Surg Am 2008; 90: pp. 2655-2664
- 59. Kijowski R., Blankenbaker D.G., Shinki K., et al: Juvenile versus adult osteochondritis dissecans of the knee: appropriate MR imaging criteria for instability. Radiology 2008; 248: pp. 571-578
- 60. Carey JL, Wall EJ, Shea KG, et al. Reliability of the ROCK osteochondritis dissecans knee arthroscopy classification system–multicenter validation study. POSNA Annual Conferece. Toronto (ON), May 1–4, 2013.
- 61. Chambers H.G., Shea K.G., Anderson A.F., et al: American Academy of Orthopaedic Surgeons clinical practice guideline on: the diagnosis and treatment of osteochondritis dissecans. J Bone Joint Surg Am 2012; 94: pp. 1322-1324
- 62. Van Demark R.E.: Osteochondritis dissecans with spontaneous healing. J Bone Joint Surg Am 1952; 34: pp. 143-148
- 63. Krause M., Hapfelmeier A., Moller M., et al: Healing predictors of stable juvenile osteochondritis dissecans knee lesions after 6 and 12 months of nonoperative treatment. Am J Sports Med 2013; 41: pp. 2384-2391
- 64. Smillie I.S.: Treatment of osteochondritis dissecans. J Bone Joint Surg Br 1957; 39-B: pp. 248-260
- 65. Kocher M.S., Tucker R., Ganley T.J., et al: Management of osteochondritis dissecans of the knee: current concepts review. Am J Sports Med 2006; 34: pp. 1181-1191
- 66. Ganley T.J., Gaugler R.L., Kocher M.S., et al: Osteochondritis dissecans of the knee. Oper Tech Sports Med 2006; 14: pp. 147-158
- 67. Beck N.A., Patel N.M., and Ganley T.J.: The pediatric knee: current concepts in sports medicine. J Pediatr Orthop B 2014; 23: pp. 59-66
- 68. Kawasaki K., Uchio Y., Adachi N., et al: Drilling from the intercondylar area for treatment of osteochondritis dissecans of the knee joint. Knee 2003; 10: pp. 257-263
- 69. Friederichs M.G., Greis P.E., and Burks R.T.: Pitfalls associated with fixation of osteochondritis dissecans fragments using bioabsorbable screws. Arthroscopy 2001; 17: pp. 542-545
- 70. Tabaddor R.R., Banffy M.B., Andersen J.S., et al: Fixation of juvenile osteochondritis dissecans lesions of the knee using poly 96L/4D-lactide copolymer bioabsorbable implants. J Pediatr Orthop 2010; 30: pp. 14-20
- 71. Kocher M.S., Czarnecki J.J., Andersen J.S., et al: Internal fixation of juvenile osteochondritis dissecans lesions of the knee. Am J Sports Med 2007; 35: pp. 712-718
- 72. Adachi N., Deie M., Nakamae A., et al: Functional and radiographic outcomes of unstable juvenile osteochondritis dissecans of the knee treated with lesion fixation using bioabsorbable pins. J Pediatr Orthop 2015; 35: pp. 82-88
- 73. Wright R.W., McLean M., Matava M.J., et al: Osteochondritis dissecans of the knee: long-term results of excision of the fragment. Clin Orthop Relat Res 2004; undefined: pp. 239-243
- 74. Anderson A.F., and Pagnani M.J.: Osteochondritis dissecans of the femoral condyles. Long-term results of excision of the fragment. Am J Sports Med 1997; 25: pp. 830-834
- 75. Murray J.R., Chitnavis J., Dixon P., et al: Osteochondritis dissecans of the knee; long-term clinical outcome following arthroscopic debridement. Knee 2007; 14: pp. 94-98
- 76. Steadman J.R., Briggs K.K., Rodrigo J.J., et al: Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 2003; 19: pp. 477-484
- 77. Gudas R., Simonaityte R., Cekanauskas E., et al: A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children. J Pediatr Orthop 2009; 29: pp. 741-748
- 78. Richter D.L., Schenck R.C., Wascher D.C., et al: Knee articular cartilage repair and restoration techniques: a review of the literature. Sports Health 2015; 8: pp. 153-160
- 79. Briggs D.T., Sadr K.N., Pulido P.A., et al: The Use of Osteochondral Allograft Transplantation for Primary Treatment of Cartilage Lesions in the Knee. Cartilage 2015; 6: pp. 203-207
- 80. Murphy R.T., Pennock A.T., and Bugbee W.D.: Osteochondral allograft transplantation of the knee in the pediatric and adolescent population. Am J Sports Med 2014; 42: pp. 635-640
- 81. Harris J.D., Siston R.A., Pan X., et al: Autologous chondrocyte implantation: a systematic review. J Bone Joint Surg Am 2010; 92: pp. 2220-2233