Nutrition Considerations for Inflammation, Pain, and Rehabilitation



Nutrition Considerations for Inflammation, Pain, and Rehabilitation


David R. Seaman






Introduction

If an unfit individual begins an exercise regimen, they are commonly told to eat a healthy diet. When someone wishes to prevent heart disease or diabetes, they are told to eat a healthy diet. When someone wishes to pursue health throughout their lifetime, they are told to eat a healthy diet. The term “healthy diet” has different meanings depending on the individual or organization involved in promoting the diet. For the purpose of this chapter, the term anti-inflammatory diet or DeFlame Diet refers to a healthy diet. Table 36.1 outlines pro-inflammatory foods versus those that are anti-inflammatory.

I coined the term “DeFlame Diet” for the purpose of simplifying the goal of the diet. We now know that foods are either anti- or noninflammatory versus pro-inflammatory, which will be described in greater detail later in this chapter. The consumption of pro-inflammatory foods creates both acute and chronic inflammation; they inflame the body. Thus, the goal of diet should be to DeFlame the body by replacing pro-inflammatory calories with those that are anti-inflammatory. Making nutrition more complicated than this approach is unwarranted and confusing, and thus, counterproductive in patient care. You will notice that not all possible calorie sources have been mentioned in Table 36.1, such as whole grains, legumes including soy and soy milk, almond milk, yogurt, or regular milk. The reason is straightforward. These calorie sources are less important/nutritious than the foods that create an anti-inflammatory state. Whether these less nutritious calorie sources are consumed should be based on achieving normal levels of inflammatory markers listed in Tables 36.2 and 36.3.








Table 36.1 Pro-inflammatory Foods Versus Anti-inflammatory Foods











Diet That Creates a Pro-inflammatory State


Diet That Creates a DeFlamed or Anti-inflammatory State


Refined sugar


Refined grains


Grain flour products


Trans fats


Refined omega-6 seed oils (corn, safflower, sunflower, peanut, etc.)


Grass-fed meat and wild game


Meats


Wild-caught fish


Shellfish


Chicken


Omega-3 eggs


Cheese


Vegetables


Salads (leafy greens)


Fruit


Tubers/roots (potato, yams, sweet potato)


Nuts (raw or dry roasted)


Omega-3 seeds: hemp, chia, flax


Dark chocolate


Spices of all kinds


Olive oil, coconut oil, butter, cream, avocado, bacon


Red wine and stout beer


Coffee and tea (green tea is best option)


Reprinted with permission from Seaman DR. The DeFlame Diet. Wilmington, NC: Shadow Panther Press; 2016.









Table 36.2 Metabolic Syndrome Markers

























Metabolic Syndrome


Abnormal Value


Date


Date


Date


Date


1. Fasting blood glucose


≥100 mg/dL


2. Fasting triglycerides


≥150 mg/dL


3. Fasting high-density lipoprotein cholesterol


<50 for women; <40 men


4. Blood pressure


≥130/85


5. Waist circumference


>35 inches women; >40 inches men










Table 36.3 General Markers of Inflammation























































Pro-inflammatory Markers


Parameters


Date


Date


Date


Date


Fasting glucose


65-80 mg/dL = ketogenic diet


80-90 = low carbohydrate diet


<100 = considered normal


100-125 = prediabetes


>125 = type 2 diabetes


2-hour postprandial glucose


<140 mg/dL = normal


140-199 = prediabetes


200+ = diabetes


Hemoglobin A1c (HbA1c)


<5.7% = normal


5.7%-6.4% = prediabetes


≥6.5% = type 2 diabetes


Fasting triglycerides


<90 mg/dL predicts controlled postprandial response


Fasting triglyceride/high-density lipoprotein ratio


>3.5 = oxidation of low-density lipoprotein cholesterol


Blood pressure goal


<120/80 = normal


120-139/80-89 = prehypertension


140-159/90-99 = Stage 1 hypertension


≥160/100 = Stage 2 hypertension


Waist circumference goal—men


33 inches or less


Waist circumference goal—women


28 inches or less


Women waist/hip ratio (risk factor for type 2 diabetes = inflammation)


<0.80 = normal


0.81-0.85 = moderate inflammation


>0.85 = high inflammation


Men waist/hip ratio (risk factor for type 2 diabetes = inflammation)


<0.95 = normal


0.96-1.0 = moderate inflammation


>1.0 = high inflammation


Body mass index


18.5-24.9 = normal


25-29.9 = overweight


≥30 = obese


hsCRP in mg/L (general marker of chronic inflammation)


<1.0 = normal


1.0-3.0 = moderate inflammation


>3.0 = high inflammation


25(OH)D (vitamin D)


32-100 ng/mL (goal at least 60-80 ng)






Reprinted with permission from Seaman DR. The DeFlame Diet. Wilmington, NC: Shadow Panther Press; 2016.


This simplified DeFlame approach to nutrition is also consistent with how rehabilitative care is generally practiced. Stabilization exercises are applied to areas of functional instability—a patient’s mental goal is to “stabilize.” Proprioceptive exercises are utilized and related deficits are identified—a patient’s mental goal is to focus on “coordination.” End range loading is performed in the direction that centralizes and abolishes pain—a patient’s mental goal is to “extend” (in most cases). Clearly, the rehabilitative goals and mind-sets are straightforward and not confusing from a practical perspective, which should be the same for diet. If dietary goals and applications are not straightforward and are instead confusing, compliance will be poor.

Nutritional supplements are often used as part of the treatment program for rehabilitating painful
musculoskeletal tissues. As with diet and rehabilitative methods, the approach with nutritional supplements should also be uncomplicated. Table 36.4 lists supplements that can be used for short- and long-term management of inflammation.1,2,3,4,5,6,7,8

Based on Tables 36.1 and 36.4, the nutritional approach to inflammation reduction is to drastically modify dietary behavior, the primary issue being the avoidance of calories from sugar, flour, and n-6 fatty acids, which should be replaced with calories from vegetables, fruit, roots/tubers, nuts. This leads to a normalization of multiple pro-inflammatory chemicals, such as nuclear factor kappa-B (NF-κB), phospholipase A2 (PLA2), cyclo-oxygenase (COX), lipoxygenase (LOX), and cytokines, which will be described in more detail in the next section of this chapter. Supplements should be taken to support or “supplement” the anti-inflammatory diet. In general, diet and supplements should not be viewed in the context of individual named conditions/diseases and this is because most conditions involve excess inflammation. In other words, inflammation is the issue, not the name of the condition that reflects the presence of inflammation in a particular parenchymal tissue.

The next section of this chapter is devoted to diet-induced inflammation. The remaining sections thereafter will describe how to view the issue in the context of rehabilitating patients with musculoskeletal pain syndromes.








Table 36.4 Supplements for Inflammation



























































Supplement


Dose


Mechanism of Action


Clinical Consideration


For Short-Term Use


Proteolytic enzymes (bromelain, trypsin, and chymotrypsin)


1,000-2,000 mg per day taken on an empty stomach


Antagonizes fibrin and cytokines


Acute inflammation after obvious injury


White willow bark


1,000-4,000 mg per day


Antagonizes free radicals, NF-κB, PLA2, COX, LOX, and collagenase


Pain exacerbation without obvious injury


For Long-Term Use


Ginger, turmeric, boswellia, and other botanicals


1,000-2,000 mg per day


Antagonizes free radicals, NF-κB, COX, and LOX


Chronic inflammation/pain management


Magnesium


200-1,000 mg per day


Involved in hundreds of enzymes; reduces inflammation and regulates central nociception


Chronic inflammation/pain management


Omega-3 fatty acids


1,000-3,000 mg per day


Precursor for anti-inflammatory mediators


Chronic inflammation/pain management


Vitamin D


1,000-10,000 IU based on blood levels


Regulates 2,000 genes including pro- and anti-inflammatory cytokines


Chronic inflammation/pain management


Probiotics


Depends on product


Reduces gut inflammation and associated systemic inflammation


Chronic inflammation/pain management


Coenzyme Q10


100 mg per day or more


ATP production, antioxidant, regulates skeletal muscle gene expression


Chronic inflammation/pain management


a-Lipoic acid


200 mg bid


ATP synthesis, antioxidant, insulin sensitivity


Chronic inflammation/pain management


ATP, adenosine triphosphate; COX, cyclo-oxygenase; LOX, lipoxygenase; NF-κB, nuclear factor kappa-B; PLA2, phospholipase A2.


Reprinted with permission from David R. Seaman.




Diet-Induced Inflammation

In 2002, I wrote an article entitled The Diet-induced Pro-inflammatory State.9 It was a challenge to get this paper published because the relationship between diet, inflammation, and pain was just emerging at that time, but to use the colloquial, the writing was clearly on the wall. It is 15 years later now and the research in this area has exploded during this time period, such that it is clearly acknowledged that diet promotes or reduces inflammation.10,11,12,13,14,15,16,17 Review articles are even being published in rehabilitation, translational science, and other journals with titles such as Nutrition and pain18 and Dietary influence on pain via the immune system,19 and Ketogenic diets and pain.20

The average American’s diet is known to be pro-inflammatory, such that very little anti-inflammatory vegetables, fruit, roots/tubers, and nuts are consumed. Instead, approximately 20% of calories come from refined sugar, 20% from refined flour, and 20% from refined omega-6 oils.21 The omega-6 oil sources include corn, safflower, sunflower, cottonseed, peanut, and soybean. Figure 36.1 outlines the general process by which these calories sources generate inflammation.22

Sugar and flour consumption creates a postprandial hyperglycemic response, such that blood glucose will enter cells in amounts greater than normal. This leads to the production of adenosine triphosphate as well as an excess of superoxide free radicals, which activate NF-κB. The nuclear factor subsequently translocates from the cytoplasm to the nucleus, wherein it induces the production of multiple inflammatory proteins. Examples include enzymes such as PLA2, COX, and LOX, which convert dietary omega-6 arachidonic acid into prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). Both PGE2 and LTB4 are referred to as pro-inflammatory eicosanoids, which promote local inflammation.

The same blood glucose surge from sugar and flour consumption causes NF-κB to promote the production of pro-inflammatory cytokines, most notably, interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF). Each of these cytokines promotes local inflammation in conjunction with the pro-inflammatory eicosanoids. Additionally, IL-6 is known to be the cytokine responsible for stimulating the liver to produce C-reactive protein (CRP).






Figure 36.1 The process by which a pro-inflammatory diet can promote inflammation and pain. Reprinted with permission from Seaman DR. The DeFlame Diet. Wilmington, NC: Shadow Panther Press; 2016.


In response to the same postprandial glucose surge, NF-κB produces many other proteins such as matrix metalloproteinases (MMPs) and growth factors, such as vascular endothelial growth factor (VEGF). Collagenase, elastase, and stromelysins are examples of MMPs, which function to degrade connective tissue, such as in joint cartilage, nucleus pulposus, annulus fibrosis, and tendons. VEGF promotes angiogenesis, which is associated with disc herniation and the development of osteoarthritis (OA).

Unlike sugar and flour, the consumption of refined omega-6 oils does not stimulate mitochondria to produce free radicals. Instead, the oils by themselves, or in combination with sugar and flour, cause lipopolysaccharide (LPS) to be released from the cell wall of gram-negative bacteria located in the small intestine release. LPS, which is also known as bacterial endotoxin, is absorbed into circulation where it, like superoxide free radicals, stimulates NF-κB to produce inflammatory proteins.

It should be understood that the inflammatory response described above occurs immediately after sugar, flour, and lipid calories are consumed.23,24,25,26 Test meals that have been used to measure this “acute dietary injury response” in healthy normal weight subjects include three slices of buttered white toast (900 calories) and a typical McDonald’s breakfast that consisted of an egg muffin, sausage muffin, and two hash brown patties (910 calories).27,28 When eating these pro-inflammatory calories on an occasional basis, it is not likely that long-term pro-inflammatory changes will occur. However, if sugar, flour, and lipids are consumed on a regular basis, and the diet is otherwise limited in polyphenol- and carotenoid-rich vegetation, multiple pro-inflammatory changes can develop.22

Chronic exposure to a pro-inflammatory diet leads to inadequacies of omega-3 fatty acids and magnesium, and because most individuals have been scared out of the sun for fear of skin cancer, vitamin D insufficiency or deficiency is the norm, rather than the exception. Each of these nutrients is known to support gut barrier integrity, which when compromised allows for a leaky gut state that permits greater absorption of LPS.27,28,29,30,31,32,33,34,35,36 The leaky gut state is also promoted by the overconsumption of sugar, flour, and oils, because each promotes the overgrowth of gram-negative bacteria in the small intestine.37,38 This dysbiosis state is further promoted by a lack of dietary prebiotics (vegetables, fruit, nuts, and roots/tubers) and probiotics from fermented foods. The net outcome is a greater absorption of LPS into circulation as illustrated in Figure 36.1.

The chronic overconsumption of sugar, flour, and omega-6 oils, coupled with a lack of exercise, will eventually lead to a reduction in high-density lipoprotein (HDL) cholesterol, which is one marker for the metabolic syndrome (see Table 36.1). Although HDL is most well known for its relationship to cardiovascular disease (CVD), it plays a key role in trapping and eliminating LPS molecules that are absorbed from the gut.39 Practically speaking, this means that weight gain and the expression of the metabolic syndrome correlate with increasing levels of circulating endotoxin, which has been associated with the eventual expression of type 2 diabetes and depression.39,40

Notice the term “adiposopathy” in Figure 36.1, which refers to sick fat or inflamed fat syndrome. Adiposity refers to the accumulation of fat mass, which initially occurs without measurable systemic inflammation. At some point during the accumulation of body fat, a pro-inflammatory shift occurs within adipose tissue.41,42 Lean adipose tissue consists of adipocytes and an anti-inflammatory profile of immune cells including T-helper 2 cells, T-regulatory cells, and M2 nonactivated macrophages These immune cells release anti-inflammatory mediators such as IL-10.

As adipocytes swell in size, there is an associated reduction and eventual disappearance of anti-inflammatory immune cells, which are replaced with pro-inflammatory T-helper 1 cells, cytotoxic T-cells, M1-activated macrophages, and mast cells. These pro-inflammatory immune cells chronically release pro-inflammatory mediators, such as the cytokines IL-1, IL-6, and TNF, as indicated in Figure 36.1, which act on NF-κB to perpetuate inflammation. Although not as robust, it should be understood that this immune profile associated with adiposopathy is similar to the immune profile associated with an infection or autoimmune disease.

Notice in Figure 36.1 that pro-inflammatory cytokines are also released by macrophages/monocytes in local tissues and in circulation, due to an insufficiency/deficiency of omega-3 fatty acids, magnesium, and vitamin D.43,44,45 The outcome is an additional source of stimulation of NF-κB and augmented inflammatory mediator release and related communication among various cell types, such as macrophages, fibroblasts, and sensory C neurons.

Described thus far are the chemical changes that occur during the “flame-up” process, which can take years to develop. It is reasonable to be curious as to when this progressively increasing inflammatory state may cause pain and other symptoms/conditions. Figure 36.1 does illustrate that sensory C neurons
generate pain; however, this is not an all or nothing phenomenon.

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Apr 17, 2020 | Posted by in PHYSICAL MEDICINE & REHABILITATION | Comments Off on Nutrition Considerations for Inflammation, Pain, and Rehabilitation
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