Issues of the Newborn
David L. Skaggs, MD, MMM
John M. (Jack) Flynn, MD
Paul D. Sponseller, MD1
Jeffrey M. Bender, MD1
1Gurus:
Just as children are not merely little adults, newborns are not just little children. When you are called for a consult in the neonatal intensive care unit (NICU), remember that newborns and premature infants have their own unique physiology and pathology, hence the field of neonatology. While orthopaedic consults to the NICU or obstetrics are not too common, there are pearls and pitfalls worthy of discussion.
Infant’s Arm Doesn’t Move
One of the more common reasons for an orthopaedic consultation in the newborn nursery is for an infant who does not move an arm. The diagnoses that come quickly to mind are brachial plexus injury or fracture. However, infection is the most important diagnosis to make, as it can usually be treated successfully if recognized early, but may lead to permanent disability if the diagnosis is delayed (Fig. 12-1).
A newborn with a painful limb will demonstrate pseudoparalysis and not move the limb voluntarily. To the inexperienced, this may be misinterpreted as a true paralysis or brachial plexus injury. One approach to help differentiate pseudoparalysis from paralysis is to shake the arm; if you are being observed, perhaps explain what you are doing so you do not look like a calloused orthopod. If the child reacts to movement with pain, the diagnosis is likely fracture or infection. If there is no sign of pain, the diagnosis is likely neurologic injury. A potential pitfall of this approach is that an infant may have a fracture or infection and a brachial plexus injury, so a neurologic examination is essential even in the case of a known fracture or infection. One series reported that nearly 10% of newborns with a clavicle fracture also had a brachial plexus palsy.1
THE GURU SAYS…
The Moro reflex (allowing the head to gently extend) can help to distinguish a child with a fracture or infection from a child with a brachial plexus injury. A child with a fracture or infection will still move the arm some-what while one with a brachial plexus palsy will not.
PAUL D. SPONSELLER
Infection
When dealing with the clinical diagnosis of infections in newborns, we enter into a different universe. In the first week of life, normal white blood cell count ranges between 9000 and 30,000 cells/mL. A total white cell count below 5000 cell/mL is generally considered to be suggestive of severe infection, although some overlap between infected and noninfected neonates occurs. Although over half of neonates with sepsis present with fever, hypothermia may be the leading sign of infection in 15% to 20% of infected neonates.
THE GURU SAYS…
Although the erythrocyte sedimentation rate (ESR) is less reliable in newborns than in later age groups, elevated C-reactive protein (CRP) values have an approximately 60% positive predictive value for infection. More importantly, normal CRP values are very useful in ruling out infections with a negative predictive value exceeding 95%.
JEFFREY BENDER
The diagnosis of osteoarticular infection may be suspected on clinical examination by a limb that appears painful when moved. In the absence of an obvious fracture on radiographs, an ultrasound should be performed which may demonstrate a septic shoulder or subperiosteal collection. Significant intra-articular pus may cause subluxation or dislocation of the joint (Fig. 12-2). A septic shoulder requires urgent surgical drainage if the newborn’s condition permits. Adjacent osteomyelitis should be expected, as vessels cross the physis at this age. Of course, many of the principals here apply to the lower extremities as well. In particular, if there is a septic hip, the other hip should be closely investigated with ultrasound and/or aspiration (Fig. 12-3).
THE GURU SAYS…
Unfortunately, examinations in neonates can be exceedingly challenging. Many infants in NICUs are born prematurely and require significant medical interventions (lines, ventilators, etc.), which put them at high risk for invasive infections and make orthopaedic evaluations that much more difficult. It is of utmost importance to maintain appropriate infection prevention measures for these immunologically immature neonates. The most important thing we can all do to help is to adhere to strict hand hygiene practices whenever examining these infants.
JEFFREY BENDER
Most osteoarticular infections in this age group will be due to Staphylococcus aureus. That being said, given the high-risk nature of this population, Group B Streptococcus, Escherichia coli, Kingella kingae, Candida species, and other pathogens are seen much more commonly here than in older children. Obtaining cultures to help direct therapy is critical in successfully treating these infections (Fig. 12-4). There are some odd infections in the newborn, such as calcaneal osteomyelitis following a heel stick.2
Figure 12-2 Note increased lateral translation of the proximal Humerus (red arrow) in routine chest X-ray, which helped diagnose a septic shoulder. Green arrow is the normal side. |
Figure 12-3 In newborns with a septic hip, the opposite hip should be evaluated very carefully for sepsis with aspiration and/or ultrasound. |
THE GURU SAYS…
Check for finger movement to determine severity and prognosis. A high percentage of cases end up as malpractice suits against obstetricians. Do what you can early to defuse the situation. Make the referrals yourself so that patient falls into care of a knowledgeable orthopaedic surgeon. Many other (nonortho) specialists treating this condition do not have as much knowledge of natural history and of all treatment options.
PAUL D. SPONSELLER
Brachial Plexus Injury
There are many degrees of injury to the brachial plexus. In the most common type with upper plexus involvement, or Erb palsy, the characteristic appearance of waiter’s tip—shoulder internal rotation, elbow extension, forearm pronation, and wrist flexion (Fig. 12-5)—aids in diagnosis. The surgeon should be aware that the phrenic nerve may be involved as well as a Horner syndrome (ptosis, miosis, and enophthalmos). Physical therapy should be started to maintain motion, as muscle imbalance may rapidly lead to contracture and joint incongruence.
THE GURU SAYS…
Slings for humeral fractures can be made with loop of stockinette (Fig. 12-7), or you can just fasten the sleeve of the garment to the chest with a safety pin. Another option for midshaft humerus fracture is to make functional above-elbow splint out of tongue depressors taped together.
PAUL D. SPONSELLER
Fractures
The big pitfall in fractures is a physeal fracture of the proximal humerus, or less commonly the distal humerus (Fig. 12-6). The humeral head and capitellum are not yet ossified, so the fracture is not easily appreciated on plain radiographs. On examination, there should be fullness, tenderness, and often warmth, similar to an infection. An ultrasound demonstrates the fracture. So the following clinical algorithm will help one make the diagnosis: arm hurts with movement, get a radiograph or ultrasound, depending on what is best at your institution. A radiograph will not show infection or some physeal fractures, so if the radiograph is negative, one must get an ultrasound. An ultrasound in the hands of an experienced user is probably the best study.3
Other fractures of the upper extremity and clavicle are more easily diagnosed on plain radiographs. Healing is very rapid, and outcome is benign with extensive remodeling the rule.4 In the newborn, immobilization in generally needed for only 7 to 10 days (Fig. 12-8). For children with multiple fractures think about osteogenesis imperfecta, neonatal rickets, or neuromuscular disorders. Femur fractures in newborns are commonly treated in newborns with a Pavlik harness.