This section is written for all of us. All of us will experience regional musculoskeletal symptoms in the near future. All of us will have to process such predicaments. This section takes on four aspects of our quandary, each in a separate chapter. Chapter 2 explores the social construction that the challenge relates solely to the severity of the episode. Could it be that the pain itself is the least of the predicament? Could it be that the pain is rendered less tolerable because the experience is confounded by coincident turmoil in our lives? The data are compelling; the answers are all affirmative. Chapter 3 examines the dangers of the diagnostic process should we come to believe that medical recourse is sensible. That is exceptional for most individuals with a regional musculoskeletal disorder. Most people with regional symptoms seldom race to a doctor. More often we attempt to sort the symptoms out for ourselves first. Usually, before we lose patience with that exercise, the symptoms regress. However, if we finally need medical assistance, it is increasingly important to understand how and when the treatment act becomes iatrogenic, making us more ill. Chapter 10 is not a primer on epidemiology. Epidemiology and biostatistics are public sciences; you cannot read the paper or listen to the news without hearing someone’s interpretation of someone else’s epidemiologic study. So much of this directly relates to regional musculoskeletal disorders, and much more is relevant. However, modern epidemiology demands a prepared ear and mind if one is to spot the hype and distortions that serve preconceived notions and marketing exercise. Some sophistication is prerequisite to coping, let alone to understanding the issues in litigation and regulation that will occupy us in Section III. Chapter 10 is designed to educate to this end. Chapter 4 applies these lessons to the vast menu we must choose from if we decide we need assistance with our next regional disorder.