Objective

The objectives were to determine whether high intensity combined training (i.e. interval aerobic exercise and strength training) may improve:

– aerobic and strength capacity;

– quality of life;

– the autonomy to exercise.

Material/patients and methods

Twenty-six multiple sclerosis patients have completed the program (19 women/7 men, age 44.6 + 7.9 years, Expanded Disability Status Score 2.46 + 1.5). A measurement of peak oxygen consumption ( VO 2 peak ) and maximal muscle strength of right and left quadriceps and hamstrings at 90–180 and 240°/s were made before and after training. A quality of live evaluation was realized with the SEP-59 questionnaire. Exercise training included 1 aerobic session on cycle ergometer and 1 session of muscular strengthening during the first 4 weeks, then 1 session in autonomy is added. Aerobic exercise started by a 10 min warm-up, then 5 times 1 min at 90% of maximal heart rate following by 3 min of recovery at anaerobic threshold. Data were expressed as means + SD. A paired t -test was used to assess significant difference ( P < 0.05) in physiological capacities and quality of life before and after exercise training. A two-way ANOVA (training and leg) repeated measurement was used to compare isokinetics changes in quadriceps and hamstrings.

Results

The muscles strength was increased by more than 10% in quadriceps and hamstrings at the different speeds. VO 2 peak as well as maximal tolerated power were improved following exercise training respectively by 13.5 and 9.4%. The SEP-59 self-questionnaire showed significant improvements in Vitality, emotional well being and general well being was. Before training 17 patients were sedentary, after 23 were engage in regular physical activity.

Discussion–conclusion

Combined exercise training:

– improved strength and VO 2 peak ;

– enhanced emotional well-being;

– encouraged the resumption of physical activity in autonomy for patients.