Classic Adolescent and Adult Acetabular Dysplasia



Classic Adolescent and Adult Acetabular Dysplasia





INTRODUCTION

Acetabular dysplasia presenting in adolescence or young adulthood can result from unresolved or undiagnosed congenital/childhood developmental dysplasia of the hip (DDH) or it can occur in hips that were anatomically normal until adolescence. Normal acetabular development continues through adolescence, and late presenting acetabular dysplasia could be a result of deficient growth just prior to skeletal maturity.1 This is postulated to be due to delayed ossification of the triradiate cartilage and insufficient development of the lateral secondary ossification centers at the acetabular rim that usually ossify between the ages of 12 and 18 years.2 Acetabular dysplasia, characterized by a shallow and oblique acetabular weight-bearing zone, leads to unfavorable mechanics and increased cartilage contact stresses, which ultimately cause early cartilage degeneration and osteoarthritis. The incidence of hip dysplasia ranges from 1.7% to 20% in the general population, with females having an increased relative risk of hip dysplasia.3 A recent US-based study of 950 patients, undergoing periacetabular osteotomy (PAO) for symptomatic acetabular dysplasia, reported 83% of the patients being females and 87.2% patients being Caucasians, with most patients being symptomatic for 1 to 3 years.4


CLINICAL ASSESSMENT

The commonest presenting complaint of patients seeking medical attention is activity-related pain around the hip.5 Patients commonly localize the pain to the groin or the greater trochanter or both. Some patients have been misdiagnosed as having primary trochanteric bursitis and have undergone prolonged prior intervention for the same, often in the form of steroid injections.

It is very uncommon for patients with dysplasia to have buttock pain unless they have associated femoroacetabular impingement (FAI). The pain associated with hip dysplasia is usually related to abnormal mechanical loading of the involved hip. In due course of time, it becomes more persistent and frequent. This pain typically improves with rest and by weight-bearing activities of the involved hip. Catching and/or popping are frequent nonspecific hip symptoms and are usually due to extra-articular causes—iliopsoas riding over the iliopectineal eminence or the iliotibial (IT) band over the trochanter. Patients often seek physical therapy regimens and/or injections in and around the hip for pain relief in the absence of a specific mechanical diagnosis.

A thorough general medical, surgical, and social history is important. The history taking should also screen for neuromuscular causes of dysplasia (e.g., myelomeningocele, Charcot-Marie-Tooth disease, hypertonia). Hip dysplasia may have a genetic component, so family history of hip dysplasia and/or of early total hip replacement (THR) in the family is also pertinent. We recommend collecting a validated hip-specific patient function instrument, such as Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) or International Hip Outcome Tool (iHOT). In addition to documenting the patient’s functional status, expectations should also be discussed during the patient interview.


Physical Examination

A brief general physical examination and a neurologic examination assessing motor power, bulk, reflexes, and sensation should precede the specific orthopedic evaluation.

Because many patients with hip dysplasia have ligamentous laxity, a screening tool like Beighton score is helpful. Beighton score is a nine-point scale that assesses joint hypermobility (Table 5.1).

A complete and accurate physical examination is facilitated if the patient wears shorts or tights. A thorough examination should include visual gait analysis followed by examination in standing, supine, prone, and side-lying position.

Focused hip examination begins with the assessment of gait, specifically looking for any limp, abductor lurch, or antalgic gait. Standing alignment in coronal and sagittal planes provides important clues, such as pelvic obliquity, scoliosis, or limb deformity. Range of motion of the
hips should be documented, as should strength of pertinent muscles and positions of discomfort or pain. Special tests are used to look for impingement and/or dysplasia. A suggested examination pattern is given in Table 5.2 and Figure 5.1.








TABLE 5.1 Beighton Score






















































Joint


Side


Finding


Point


Little finger


Right


Passive dorsiflexion beyond 90°


1


Left


1


Thumb


Right


Passive dorsiflexion to the flexor aspect of the forearm


1


Left


1


Elbow


Right


Active hyperextension beyond 10°


1


Left


1


Knee


Right


Active hyperextension beyond 10°


1


Left


1


Forward flexion of the trunk with knees fully extended



Palms touch the floor


1



Palms do not rest on the floor


0


Total




9









TABLE 5.2 Hip Examination


































Patient Position


Assessment


Note


Standing/walking


Visual gait examination


Limp/abductor lurch.


Stance


Pelvic obliquity, limb length discrepancy, spine deformity.


Trendelenburg test



Supine


Hip range of motion with special mention of hip rotations with hip flexed and extended.



Apprehension test


Anterior hip pain or apprehension noticed when the contralateral hip is hyperflexed to the chest and the index hip is extended and internally rotated in slight adduction. This is indicative of possible rim damage or instability.


Anterior impingement sign


Pain, localized to the groin region, with compression of anterior rim structures on flexion, adduction, and internal rotation of the involved hip. Usually positive if there is labral or acetabular rim most likely secondary to abnormal femoral head-neck anatomy.


Side-lying


Hip abductor power



Trochanteric tenderness




RADIOGRAPHIC ASSESSMENT

Patients presenting with hip symptoms due to underlying hip dysplasia may benefit from joint preserving surgery. Undiagnosed acetabular dysplasia usually leads to osteoarthritis, which may require otherwise-avoidable hip replacement. Hence, prompt diagnosis of dysplasia is important. Appropriate imaging is needed to assess acetabular dysplasia and to plan out further treatment. Plain radiographs, advanced cross-sectional imaging (computed tomography [CT] scans and magnetic resonance imaging [MRI]), and dynamic ultrasound assessment are important tools and have specific roles in the diagnosis and treatment of acetabular dysplasia. In addition to getting the appropriate projections, it is also important to have strict criteria to assess the quality of the images.6

The radiograph remains the gold standard for assessing structural hip abnormalities, including hip dysplasia. The minimum radiographic data set that are generally
employed in assessing mature acetabular dysplasia include a well-centered anteroposterior (AP) radiograph of the entire pelvis (standing preferred in the United States; supine is preferred in Europe), faux profil views, and a modified Dunn lateral radiograph, taken in 45° of flexion, 30° of abduction, and neutral rotation, to show in profile that anterolateral neck area is the most common location of reduced offset. The AP radiograph is evaluated with measures of lateral and anterior coverage (lateral center-edge angle [LCEA], Figures 5.2, 5.3 and 5.4, Shenton line intact or broken). The faux profil view predominantly assesses anterior coverage, quantitated by the anterior CE angle (Figure 5.5). The modified Dunn lateral helps in identification of a proximal femur cam
deformity (Figure 5.6). All radiographs should be scrutinized for changes indicative of osteoarthritis, including cartilage space width and appearance of the subchondral bone. Table 5.3 presents the relevant measurements commonly made on these radiographs. For preoperative assessment of patients being considered for PAO, anticipated postoperative congruity is best confirmed by functional flexion, abduction, and internal rotation radiographs, simulating effect of the proposed redirection (Figure 5.7).






FIGURE 5.1. Clinic visit summary outline. AVN, avascular necrosis; CMT, Charcot-Marie-Tooth; DDH, developmental dysplasia of the hip; ER, external rotation; Hx, history; IR, internal rotation; SCFE, slipped capital femoral epiphysis; SI, sacroiliac; wt, weight.






FIGURE 5.2. Lateral center-edge angle of Wiberg formed between the two lines passing through the center of the femoral head one of which extends to the lateral edge of sourcil and the line perpendicular to that joining the centers of the two femoral heads (of the two hips). The normal angle of an adult is greater than 25°. Beyond 40° may indicate pincer impingement.






FIGURE 5.3. Tönnis angle. The angle formed by the intersection of horizontal line connecting the femoral head centers and the line that passes through medial edge of the sourcil. Tönnis angle greater than 10° is indicative of structural instability and less than 0° of pincer-type femoroacetabular impingement.






FIGURE 5.4. Anterior wall index (AWI) and posterior wall index (PWI). The AWI and PWI are calculated by dividing the distance of the anterior wall (AW) or posterior wall (PW) along the femoral neck line to the outer edge of the best fit sphere for femoral head by the radius (r) of the femoral head.

Additional imaging sometimes useful in assessing hip deformity and selecting treatment includes lowdose CT and MRI. CT in particular has improved our
three-dimensional understanding of acetabular deformity in dysplasia. Acetabular dysplasia presents with three patterns of undercoverage: anterior, posterior, and global.7,8 Recognition of the pattern of acetabular deficiency is critical in selecting the optimal acetabular reorientation. MRI allows evaluation of intra- and extra-articular soft-tissue structures of the hip affected by acetabular dysplasia. The acetabular labrum should be assessed for damage at the chondrolabral junction as well as global hypertrophy, both of which can remain symptomatic following PAO, if not addressed. In our institution, CT and MRI are also used to assess acetabular and femoral version. MR cartilage-specific sequences, such as delayed gadolinium-enhanced MRI (dGEMRIC), are invaluable in evaluating cartilage health (Figure 5.8) in hips with signs of early osteoarthritis. Preoperative dGEMRIC scores have been shown to have a predictive value in the survival of PAO9 (Figure 5.9).






FIGURE 5.5. Anterior center-edge angle of Lequesne. A vertical line is drawn through the center of the femoral head intersecting another line drawn through the center of the femoral head, passing through the most anterior point of the acetabular sourcil. The angle created by the intersection of these two lines is measured.






FIGURE 5.6. 45° Dunn view. An α angle is formed by intersection of lines drawn. 1. From the center of the femoral head through the center of the femoral neck. 2. From the center of the femoral head to the femoral head/neck junction, found by the point by which the femoral neck diverges from a circle drawn around the femoral head.








TABLE 5.3 Common Radiographic Measurements
















































Normal


Abnormal


AP pelvis x-ray


Lateral center-edge angle


Between 25° and 35°


<25° may indicate instability.


Tönnis angle


Between 0° and 10°.


>10° may indicate instability.


<0° may subject to pincer impingement.


Anterior wall index


Between 15% and 30%


<15% dysplasia;


>33% overcoverage.


Posterior wall index


Between 35% and 50%


<35% dysplasia;


>50% overcoverage.


Shenton line


Smooth contour of the arc.


Disruption of more than 5 mm.


Neck shaft angle


Between 130° and 140°.


<120° coxa vara;


>140° coxa valga.


Faux profil


Anterior center-edge angle


Between 25° and 35°.


<20° considered dysplastic.


Modified Dunn view


α Angle


<55°


>55° in females and >60° in males is indicative of a cam deformity causing femoroacetabular impingement.


AP, anteroposterior.







FIGURE 5.7. Von Rosen view. Anteroposterior radiograph done with both lower extremities in maximal abduction and internal rotation showing lateral coverage and joint congruity. The yellow curved lines demonstrate joint congruity and lateral coverage.







FIGURE 5.8. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC). dGEMRIC is sensitive to the charge density of cartilage contributed by glycosaminoglycans (GAGs), which are lost early in the process of osteoarthritis. A higher number signifies healthier cartilage. Red color in the figure signifies lower dGEMRIC score and hence articular cartilage damage compared to yellow which signifies healthier cartilage.






FIGURE 5.9. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage values plotted against probability of early failure after a joint preserving periacetabular osteotomy (PAO). From Cunningham et al.9

Moving beyond static imaging, dynamic ultrasonography is being used at our center as a diagnostic tool in assessing both instability and impingement even in mature hips in which the mechanics are poorly understood.10


PATIENT SELECTION

The only multicenter prospective cohort study looking at outcomes after PAO, by the ANCHOR (Academic Network of Conservational Hip Outcomes Research) group, reported improved patient-reported outcomes, with a minimum follow-up of 2 years (mean = 2.6, 2-5.4 years) in 391 hips and a 99.2% hip survival rate and 93% early satisfaction rate. They reported improvements in pain, function, quality of life, overall health, and activity level. Increasing age and a body mass index status of overweight or obesity were predictive of improved results for certain outcome metrics. Male sex and mild acetabular dysplasia were predictive of lesser improvements in certain outcome measures. Three (0.8%) of the hips underwent early conversion to total hip arthroplasty, 12 (3%) required reoperation, and 26 (7%) experienced a major complication.11

Multiple retrospective studies report outcomes of PAO. The Bernese experience has the longest minimum follow-up of 30 years, noting conversion rate to total hip arthroplasty or arthrodesis of 12.4% at 10 years and 39.5% at 20 years. At 30-year follow-up, 30% of hips were asymptomatic without radiographic evidence of progression.12,13,14

Similar results from our center showed cumulative survival of 76% at 10-year follow-up and 74% at mean 18-year follow-up. At a mean of 18 years after PAO, 53% of patients were asymptomatic, and 26% were symptomatic based on WOMAC pain score greater than 10. In all, 21% of hips had been replaced, with a mean age of 9 years post-PAO.15,16

Troelsen et al described similar results from another high-volume PAO center, with 82% of hips surviving for a decade following surgery.17,18,19

Factors associated with poor outcome included older age, the severity of osteoarthritis, and evidence of labral pathology and poor acetabular index postoperatively.
Even though widely accepted, the use of conversion to THR as an end point is in some ways problematic. At the time of follow-up, more patients may have developed endstage hip joint osteoarthritis or functionally compromising pain. These hip joints may also require THR in the near future; thus, the true failure rate may be underestimated. There is no commonly accepted definition of which secondary end points to consider. While the overall results among most studies looking at mid- to long-term outcomes were consistent, the characteristics of failed PAOs were also highly similar. Older patients, patients with severe preoperative dysfunction, radiographic osteoarthritis, and poor joint congruency prior to surgery were strong predictors of PAO failure in a number of studies.

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May 10, 2021 | Posted by in ORTHOPEDIC | Comments Off on Classic Adolescent and Adult Acetabular Dysplasia
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