RHEUMATOLOGY

Innate immunity

May 20, 2021 by in RHEUMATOLOGY Comments Off on Innate immunity

• Innate immunity provides the frontline ready-made response to pathogen invasion. • These same pathways are activated in response to other critical insults, including trauma, hypoxic/ischemic injury, and bypass. •…

read more

Adaptive immunity

May 20, 2021 by in RHEUMATOLOGY Comments Off on Adaptive immunity

• Unlike the innate immune response, the adaptive immune response is characterized by specific antigen recognition and immunologic memory. • Lymphocytes are the key cell types of the adaptive immune…

read more

Nutrition of the critically ill child

May 20, 2021 by in RHEUMATOLOGY Comments Off on Nutrition of the critically ill child

• Provision of individually tailored optimal nutrition is an important goal of pediatric critical care. • Malnutrition is prevalent in the pediatric intensive care unit (PICU) and is associated with…

read more

Malignant hyperthermia

May 20, 2021 by in RHEUMATOLOGY Comments Off on Malignant hyperthermia

• Risk factors for malignant hyperthermia (MH) include a family history of severe hyperthermia or sudden hypermetabolic state during anesthesia with exposure to succinylcholine and/or potent inhalation anesthetics, and ryanodine…

read more

Hypoxic-ischemic encephalopathy

May 20, 2021 by in RHEUMATOLOGY Comments Off on Hypoxic-ischemic encephalopathy

Pearls • Cardiac arrest in pediatric patients is predominantly due to asphyxia. This is in contrast to adults, for whom, despite an increase in asphyxial cardiac arrest related to the…

read more

Tolerance, dependency, and withdrawal

May 20, 2021 by in RHEUMATOLOGY Comments Off on Tolerance, dependency, and withdrawal

• Physical dependency and withdrawal have been documented in all agents used for sedation and analgesia in the pediatric intensive care unit, including benzodiazepines, barbiturates, opioids, dexmedetomidine, propofol, and the…

read more

Neuromuscular blocking agents

May 20, 2021 by in RHEUMATOLOGY Comments Off on Neuromuscular blocking agents

• Through the blockade of skeletal muscle function, neuromuscular blocking agents (NMBAs) cause cessation of respiratory function, mandating airway control and the institution of mechanical ventilation. NMBAs should not be…

read more
Get Clinical Tree app for offline access