MUSCULOSKELETAL MEDICINE

Muscular Dystrophies and Allied Disorders IV: Emery–Dreifuss Muscular Dystrophy and Similar Syndromes

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Muscular Dystrophies and Allied Disorders IV: Emery–Dreifuss Muscular Dystrophy and Similar Syndromes

Joint contractures are a common complication of several neuromuscular disorders, but in some they are an early feature and specific joints are commonly affected. In particular, disorders known as Emery–Dreifuss…

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Neurogenic Disorders

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Neurogenic Disorders

There are many inherited and acquired clinical disorders caused by a defect in upper or lower motor neurone or the peripheral nerve. These include amyotrophic lateral sclerosis (ALS; upper and…

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Ultrastructural Changes

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Ultrastructural Changes

Skeletal muscle undergoes many changes in response to disease and trauma. With the electron microscope, the abnormalities seen at the light level can be characterized and accurately localized, and the…

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Immunohistochemistry and Immunoblotting

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on Immunohistochemistry and Immunoblotting

Immunohistochemistry Immunohistochemistry has an essential role in the evaluation of muscle biopsies and in examining protein localization. The term ‘protein expression’ is often applied to describe immunohistochemical results, but it…

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How to Read a Biopsy

Feb 23, 2021 by in MUSCULOSKELETAL MEDICINE Comments Off on How to Read a Biopsy

When the pathologist is asked to evaluate a muscle biopsy, much of the interpretation is based on his or her previous experience and the recognition of similarities between the biopsy…

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